View Item 

Show simple item record

Synthesis of imidazo[1,2‐ b ]pyridazines: Fenbendazole, oxifenbendazole analogs and related derivatives
dc.contributor.authorMourad, Alaa E.en_US
dc.contributor.authorWise, Dean S.en_US
dc.contributor.authorTownsend, Leroy B.en_US
dc.date.accessioned2013-02-12T19:01:26Z
dc.date.available2013-02-12T19:01:26Z
dc.date.issued1993-10en_US
dc.identifier.citationMourad, Alaa E.; Wise, Dean S.; Townsend, Leroy B. (1993). "Synthesis of imidazo[1,2‐ b ]pyridazines: Fenbendazole, oxifenbendazole analogs and related derivatives ." Journal of Heterocyclic Chemistry 30(5): 1365-1372. <http://hdl.handle.net/2027.42/96428>en_US
dc.identifier.issn0022-152Xen_US
dc.identifier.issn1943-5193en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/96428
dc.description.abstractA series of imidazo[1,2‐ b ]pyridazines has been prepared and evaluated for macrofilaricidal activity against Brugia pahangi or Acanthocheilonema viteae infections in jirds. The imidazo[1,2‐ b ]pyridazine analogs of fen‐bendazole and oxifenbendazole are reported. In addition, several 6‐aminoimidazo[1,2‐ b ]pyridazine derivatives have been prepared. None of these compounds possessed significant activity against human cytomega‐lovirus (HCMV) or filarial infections.en_US
dc.publisherWiley‐Blackwellen_US
dc.titleSynthesis of imidazo[1,2‐ b ]pyridazines: Fenbendazole, oxifenbendazole analogs and related derivativesen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelOrganic Chemistryen_US
dc.subject.hlbtoplevelScienceen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Medicinal Chemistry, College of Pharmacy and Department of Chemistry, The University of Michigan, Ann Arbor, Michigan 48109–1065en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/96428/1/5570300531_ftp.pdf
dc.identifier.doi10.1002/jhet.5570300531en_US
dc.identifier.sourceJournal of Heterocyclic Chemistryen_US
dc.identifier.citedreferenceG. M. Dyson and R. F. Hunter, J. Soc. Chem. Ind., 45, 81 ( 1926 ).en_US
dc.identifier.citedreferenceS. J. Assony, Organic Sulfur Compounds,Vol 1, Pergamon Press, Oxford, 1961,p 326;en_US
dc.identifier.citedreferenceS. Patai, The Chemistry of Cyanates and Their Thio Derivatives,Part II, John Wiley and Sons, New York, 1977,p 1003.en_US
dc.identifier.citedreferenceM. Vlassa and Maria Kezdi, J. Prakt. Chem., 327, 1007 ( 1985 ).en_US
dc.identifier.citedreferenceP. Kristian, Chem. Zvesti, 15, 641 ( 1961 ).en_US
dc.identifier.citedreferenceP. Kristian, Chem. Zvesti, 23, 371 ( 1969 ).en_US
dc.identifier.citedreferenceOrg. Synth., 21, 81 ( 1941 ).en_US
dc.identifier.citedreferenceG. J. O. Niel and F. L. Pattison, J. Am. Chem. Soc., 79, 1956 ( 1957 ).en_US
dc.identifier.citedreferenceG. M. Dyson, H. J. George and R. F. Hunter, J. Chem. Soc., 436 ( 1927 ).en_US
dc.identifier.citedreferenceR. L. McKee and R. W. Bast, J. Am. Chem. Soc., 68, 2506 ( 1946 ).en_US
dc.identifier.citedreferenceW. Siefken, Liebigs Ann. Chem., 562, 75 ( 1947 ).en_US
dc.identifier.citedreferenceL. J. Bellamy, Advances in Infrared Group Frequencies, London, Methuen, 1968.en_US
dc.identifier.citedreferenceR. M. Silverstein, G. C. Bassler and T. C. Morrill, Spectroscopic Identification of Organic Compounds, Fourth Edition, John Wiley and Sons, Inc., New York, 1981.en_US
dc.identifier.citedreferenceJ. Druey, Helv. Chim Acta, 37, 121 ( 1954 ).en_US
dc.identifier.citedreferenceT. Horie, Chem. Pharm. Bull., 10, 580 ( 1962 ).en_US
dc.identifier.citedreferenceJ. W. McCall, T. L. McTier and S. J. Rowan, The Proceedings of a Symposium on Onchocerciasis/Filariasis, G. A. Condor and J. F. Williams, eds, Upjohn Co., Kalamazoo, MI,April 8–10, 1986,pp 23 – 33.en_US
dc.identifier.citedreferenceS. R. Turk, C. Shipman, Jr., R. Nassiri, G. Genzlinger, S. H. Krawczyk, L. B. Townsend and J. C. Drach, Antimicrob. Agents Chem‐other., 31, 544 ( 1987 ).en_US
dc.identifier.citedreferenceS. Ram, W. Evans, D. S. Wise and L. B. Townsend, J. Heterocyclic Chem., 26, 1053 ( 1989 ).en_US
dc.identifier.citedreferenceJ.‐W. Chern, H.‐Y. Lee, D. S. Wise and L. B. Townsend, J. Org. Chem., 53, 5617 ( 1988 ).en_US
dc.identifier.citedreferenceS. Ram, D. S. Wise and L. B. Townsend, J. Heterocyclic Chem., 23, 1109 ( 1986 ).en_US
dc.identifier.citedreferenceA. E. Mourad, D. S. Wise and L. B. Townsend, J. Heterocyclic Chem., 29, 1583 ( 1992 ).en_US
dc.identifier.citedreferenceF. Yoneda, T. Otaka and Y. Nitta, Chem. Pharm. Bull., 12, 1351 ( 1964 ); Chem. Abstr., 62, 5273 ( 1965 ).en_US
dc.identifier.citedreferenceL. Almirante, L. Polo, A. Mugnaini, E. Provinciali, P. Rugarli, A. Gamba, A. Olivi and W. Murmann, J. Med. Chem., 9, 29 ( 1966 ).en_US
dc.identifier.citedreferenceJ. Kobe, B. Stanovnik and M. Tisler, Tetrahedron, 24, 239 ( 1968 ).en_US
dc.identifier.citedreferenceA. Pollak, B. Stanovnik and M. Tisler, Tetrahedron, 24, 2623 ( 1969 ).en_US
dc.identifier.citedreferenceJ. G. Lombardino, J. Heterocyclic Chem., 5, 35 ( 1968 ).en_US
dc.identifier.citedreferenceBelgian Patent 579,291( 1959 );en_US
dc.identifier.citedreferenceT. Horie, K. Kinio and T. Ueda, Chem. Pharm. Bull., 10, 580 ( 1962 ).en_US
dc.identifier.citedreferenceUnited Kingdom Patent, GB‐2,076,399to Ciba Geigy AG,( 1982 ).en_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


Files in this item

Name:
5570300531_ftp.pdf
Size:
708.4KB
Format:
PDF
View/Open

Show simple item record

Remediation of Harmful Language

The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.

Accessibility

If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.