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The Effect of Dosage Release Formulations on the Pharmacokinetics of Propranolol Stereoisomers in Humans
dc.contributor.authorBleske, Barry E.en_US
dc.contributor.authorWelage, Lynda S.en_US
dc.contributor.authorRose, Steveen_US
dc.contributor.authorAmidon, Gordon L.en_US
dc.contributor.authorShea, Michael J.en_US
dc.date.accessioned2013-04-08T20:49:26Z
dc.date.available2013-04-08T20:49:26Z
dc.date.issued1995-04en_US
dc.identifier.citationBleske, Barry E.; Welage, Lynda S.; Rose, Steve; Amidon, Gordon L.; Shea, Michael J. (1995). "The Effect of Dosage Release Formulations on the Pharmacokinetics of Propranolol Stereoisomers in Humans." The Journal of Clinical Pharmacology 35(4). <http://hdl.handle.net/2027.42/97148>en_US
dc.identifier.issn0091-2700en_US
dc.identifier.issn1552-4604en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/97148
dc.publisherBlackwell Publishing Ltden_US
dc.publisherWiley Periodicals, Inc.en_US
dc.titleThe Effect of Dosage Release Formulations on the Pharmacokinetics of Propranolol Stereoisomers in Humansen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPharmacy and Pharmacologyen_US
dc.subject.hlbsecondlevelPediatricsen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumCollege of Pharmacy, University of Michiganen_US
dc.contributor.affiliationumDepartment of Pharmacy, University of Michigan Hospitalsen_US
dc.contributor.affiliationumHeart Station and Cardiology Outpatient Services, University of Michigan Hospitals, all in Ann Arbor, Michigan.en_US
dc.contributor.affiliationotherParke‐Davis Pharmaceutical Research Divisionen_US
dc.identifier.pmid7650226en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/97148/1/j.1552-4604.1995.tb04076.x.pdf
dc.identifier.doi10.1002/j.1552-4604.1995.tb04076.xen_US
dc.identifier.sourceThe Journal of Clinical Pharmacologyen_US
dc.identifier.citedreferenceWard SA, Walle T, Walle UK, Wilkinson GR, Branch RA: Propranolol's metabolism is determined by both mephenytoin and debrisoquin hydroxylase activities. Clin Pharmacol Ther 1989; 45: 72 – 79.en_US
dc.identifier.citedreferenceWalle T, Webb JG, Bagwell EE, Walle UK, Daniell HB, Gaffney TE: Stereoselective delivery and actions of beta receptor antagonists. Biochem Pharmacol 1988; 37: 115 – 124.en_US
dc.identifier.citedreferenceHunt BA, Bottorff MB, Herring VL, Self TH, Lalonde RL: Effects of calcium channel blockers on the pharmacokinetics of propranolol stereoisomers. Clin Pharmacol Ther 1990; 47: 584 – 591.en_US
dc.identifier.citedreferenceRose SE, Leesman GD, Amidon GL: A model for predicting drug isomer plasma levels from oral controlled release dosage forms: Application to (+) and (−) propranolol. Proc Intern Symp Control Rel Bioact Mater 1990: 17.en_US
dc.identifier.citedreferenceBarrett AM, Cullum VA: The biological properties of the optical isomers of propranolol and their effects on cardiac arrhythmias. Br J Pharmacol 1968; 34: 43 – 55.en_US
dc.identifier.citedreferenceLalonde RL, Bottorff MB, Straka RJ, Tenero DM, Pieper JA, Wainer IW: Nonlinear accumulation of propranolol enantiomers. Br J Clin Pharmacol 1988; 26: 100 – 102.en_US
dc.identifier.citedreferenceVon Bahr C, Hermansson J, Tawara K: Plasma levels of (+) and (−) propranolol and 4‐hydroxypropranolol after administration of racemic (±)‐propranolol in man. Br J Clin Pharmacol 1982; 14: 79 – 82.en_US
dc.identifier.citedreferenceOlanoff LS, Walle T, Walle UK, Cowart TD, Gaffney TE: Stereoselective clearance and distribution of intravenous propranolol. Clin Pharmacol Ther 1984; 35: 755 – 761.en_US
dc.identifier.citedreferenceRose SE, Randinitis EJ: A high‐performance liquid chromatographic assay for the enantiomers of bevantolol in human plasma. Pharm Res 1991; 8: 758 – 762.en_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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