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Microfluidic wound bandage: Localized oxygen modulation of collagen maturation
dc.contributor.authorLo, Joe F.en_US
dc.contributor.authorBrennan, Martinen_US
dc.contributor.authorMerchant, Zameeren_US
dc.contributor.authorChen, Linen_US
dc.contributor.authorGuo, Shujuanen_US
dc.contributor.authorEddington, David T.en_US
dc.contributor.authorDiPietro, Luisa A.en_US
dc.date.accessioned2013-04-08T20:50:05Z
dc.date.available2014-05-01T14:28:28Zen_US
dc.date.issued2013-03en_US
dc.identifier.citationLo, Joe F.; Brennan, Martin; Merchant, Zameer; Chen, Lin; Guo, Shujuan; Eddington, David T.; DiPietro, Luisa A. (2013). "Microfluidic wound bandage: Localized oxygen modulation of collagen maturation." Wound Repair and Regeneration (2): 226-234. <http://hdl.handle.net/2027.42/97268>en_US
dc.identifier.issn1067-1927en_US
dc.identifier.issn1524-475Xen_US
dc.identifier.urihttps://hdl.handle.net/2027.42/97268
dc.description.abstractRestoring tissue oxygenation has the potential to improve poorly healing wounds with impaired microvasculature. Compared with more established wound therapy using hyperbaric oxygen chambers, topical oxygen therapy has lower cost and better patient comfort, although topical devices have provided inconsistent results. To provide controlled topical oxygen while minimizing moisture loss, a major issue for topical oxygen, we have devised a novel wound bandage based on microfluidic diffusion delivery of oxygen. In addition to modulating oxygen from 0 to 100% in 60 seconds rise time, the microfluidic oxygen bandage provides a conformal seal around the wound. When 100% oxygen is delivered, it penetrates wound tissues as measured in agar phantom and in vivo wounds. Using this microfluidic bandage, we applied the oxygen modulation to 8 mm excisional wounds prepared on diabetic mice. Treatment with the microfluidic bandage demonstrated improved collagen maturity in the wound bed, although only marginal differences were observed in total collagen, microvasculature, and external closure rates. Our results show that proper topical oxygen can improve wound parameters underneath the surface. Because of the ease of fabrication, the oxygen bandage represents an economical yet practical method for oxygen wound research.en_US
dc.publisherWiley Periodicals, Inc.en_US
dc.titleMicrofluidic wound bandage: Localized oxygen modulation of collagen maturationen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelMedicine (General)en_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.identifier.pmid23438079en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/97268/1/wrr12021.pdf
dc.identifier.doi10.1111/wrr.12021en_US
dc.identifier.sourceWound Repair and Regenerationen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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