Associations of testosterone and sex hormone binding globulin with adipose tissue hormones in midlife women
dc.contributor.author | Wildman, Rachel P. | en_US |
dc.contributor.author | Wang, Dan | en_US |
dc.contributor.author | Fernandez, Ivonne | en_US |
dc.contributor.author | Mancuso, Peter | en_US |
dc.contributor.author | Santoro, Nanette | en_US |
dc.contributor.author | Scherer, Philipp E. | en_US |
dc.contributor.author | Sowers, MaryFran R. | en_US |
dc.date.accessioned | 2013-05-02T19:35:27Z | |
dc.date.available | 2014-05-01T14:28:33Z | en_US |
dc.date.issued | 2013-03 | en_US |
dc.identifier.citation | Wildman, Rachel P.; Wang, Dan; Fernandez, Ivonne; Mancuso, Peter; Santoro, Nanette; Scherer, Philipp E.; Sowers, MaryFran R. (2013). "Associations of testosterone and sex hormone binding globulin with adipose tissue hormones in midlife women ." Obesity 21(3): 629-636. <http://hdl.handle.net/2027.42/97532> | en_US |
dc.identifier.issn | 1930-7381 | en_US |
dc.identifier.issn | 1930-739X | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/97532 | |
dc.description.abstract | Objective: Regulators of adipose tissue hormones remain incompletely understood, but may include sex hormones. As adipose tissue hormones have been shown to contribute to numerous metabolic and cardiovascular disorders, understanding their regulation in midlife women is of clinical importance. Therefore, we assessed the associations between testosterone (T) and sex hormone binding globulin (SHBG) with leptin, high molecular weight (HMW) adiponectin, and the soluble form of the leptin receptor (sOB‐R) in healthy midlife women. Design and Methods: Cross‐sectional analyses were performed using data from 1,881 midlife women (average age 52.6 (±2.7) years) attending the sixth Annual follow‐up visit of the multiethnic Study of Women's Health Across the Nation. Results: T was weakly negatively associated with both HMW adiponectin and sOB‐R ( r = −0.12 and r = −0.10, respectively; P < 0.001 for both), and positively associated with leptin ( r = 0.17; P < 0.001). SHBG was more strongly and positively associated with both HMW adiponectin and sOB‐R ( r = 0.29 and r = 0.24, respectively; P < 0.001 for both), and more strongly and negatively associated with leptin ( r = −0.27; P < 0.001). Adjustment for fat mass, insulin resistance, or waist circumference only partially diminished associations with HMW adiponectin and sOB‐R, but attenuated associations with leptin. In conclusion, in these midlife women, lower SHBG values, and to a lesser extent, higher T levels, were associated with lower, or less favorable, levels of adiponectin and sOB‐R, independent of fat mass. Conclusions: These data suggest that variation in these adipose hormones resulting from lower SHBG levels, and possibly, though less likely, greater androgenicity, may contribute to susceptibility for metabolic and cardiovascular outcomes during midlife in women. | en_US |
dc.publisher | John Wiley & Sons, Inc. | en_US |
dc.title | Associations of testosterone and sex hormone binding globulin with adipose tissue hormones in midlife women | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Endocrinology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Department of Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationother | Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York, USA | en_US |
dc.contributor.affiliationother | Touchstone Diabetes Center,Departments of Internal Medicine and Cell Biology, The University of Texas Southwestern Medical Center, Dallas, Texas, USA | en_US |
dc.contributor.affiliationother | Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado, USA | en_US |
dc.contributor.affiliationother | Department of Internal Medicine, Englewood Hospital, Affiliate of Mount Sinai School of Medicine, Englewood, New Jersy, USA | en_US |
dc.contributor.affiliationother | Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York, USA | en_US |
dc.identifier.pmid | 23592672 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/97532/1/20256_ftp.pdf | |
dc.identifier.doi | 10.1002/oby.20256 | en_US |
dc.identifier.source | Obesity | en_US |
dc.identifier.citedreference | Laughlin GA, Barrett‐Connor E, May S. Sex‐specific determinants of serum adiponectin in older adults: the role of endogenous sex hormones. Int J Obes (Lond) 2007; 31: 457 ‐ 465. | en_US |
dc.identifier.citedreference | Chumlea WC, Guo SS, Kuczmarski RJ et al. Body composition estimates from NHANES III bioelectrical impedance data. Int J Obes Relat Metab Disord 2002; 26: 1596 ‐ 1609. | en_US |
dc.identifier.citedreference | Sternfeld B, Ainsworth BE, Quesenberry CP. Physical activity patterns in a diverse population of women. Prev Med 1999; 28: 313 ‐ 323. | en_US |
dc.identifier.citedreference | Little RJA, Rubin DB. Statistical Analysis with Missing Data, 2nd edn, John Wiley: New York, 2002. | en_US |
dc.identifier.citedreference | Dieudonne MN, Pecquery R, Boumediene A, Leneveu MC, Giudicelli Y. Androgen receptors in human preadipocytes and adipocytes: regional specificities and regulation by sex steroids. Am J Physiol 1998; 274: C1645 ‐ C1652. | en_US |
dc.identifier.citedreference | Anderson DC. Sex‐hormone‐binding globulin. Clin Endocrinol (Oxf) 1974; 3: 69 ‐ 96. | en_US |
dc.identifier.citedreference | Rosner W, Hryb DJ, Kahn SM, Nakhla AM, Romas NA. Interactions of sex hormone‐binding globulin with target cells. Mol Cell Endocrinol 2010; 316: 79 ‐ 85. | en_US |
dc.identifier.citedreference | Tworoger SS, Mantzoros C, Hankinson SE. Relationship of plasma adiponectin with sex hormone and insulin‐like growth factor levels. Obesity (Silver Spring) 2007; 15: 2217 ‐ 2224. | en_US |
dc.identifier.citedreference | Sieminska L, Wojciechowska C, Niedziolka D et al. Effect of postmenopause and hormone replacement therapy on serum adiponectin levels. Metab Clin Exp 2005; 54: 1610 ‐ 1614. | en_US |
dc.identifier.citedreference | Yasui T, Tomita J, Miyatani Y et al. Associations of adiponectin with sex hormone‐binding globulin levels in aging male and female populations. Clin Chim Acta 2007; 386: 69 ‐ 75. | en_US |
dc.identifier.citedreference | Onat A, Hergenç G, Dursunoglu D et al. Relatively high levels of serum adiponectin in obese women, a potential indicator of anti‐inflammatory dysfunction: relation to sex hormone‐binding globulin. Int J Biol Sci 2008; 4: 208 ‐ 214. | en_US |
dc.identifier.citedreference | Zastrow O, Seidel B, Kiess W et al. The soluble leptin receptor is crucial for leptin action: evidence from clinical and experimental data. Int J Obes Relat Metab Disord 2003; 27: 1472 ‐ 1478. | en_US |
dc.identifier.citedreference | Hoggard N, Mercer JG, Rayner DV et al. Localization of leptin receptor mRNA splice variants in murine peripheral tissues by RT‐PCR and in situ hybridization. Biochem Biophys Res Commun 1997; 232: 383 ‐ 387. | en_US |
dc.identifier.citedreference | Merki‐Feld GS, Imthurn B, Rosselli M, Spanaus K. Serum concentrations of high‐molecular weight adiponectin and their association with sex steroids in premenopausal women. Metab Clin Exp 2011; 60: 180 ‐ 185. | en_US |
dc.identifier.citedreference | Laughlin GA, Barrett‐Connor E, May S. Sex‐specific association of the androgen to oestrogen ratio with adipocytokine levels in older adults: the Rancho Bernardo Study. Clin Endocrinol (Oxf) 2006; 65: 506 ‐ 513. | en_US |
dc.identifier.citedreference | Rolland YM, Perry HM 3rd, Patrick P, Banks WA, Morley JE. Leptin and adiponectin levels in middle‐aged postmenopausal women: associations with lifestyle habits, hormones, and inflammatory markers‐a cross‐sectional study. Metab Clin Exp 2006; 55: 1630 ‐ 1636. | en_US |
dc.identifier.citedreference | Kobayashi H, Ouchi N, Kihara S et al. Selective suppression of endothelial cell apoptosis by the high molecular weight form of adiponectin. Circ Res 2004; 94: e27 ‐ e31. | en_US |
dc.identifier.citedreference | Lambrinoudaki I, Christodoulakos G, Panoulis C et al. Determinants of serum leptin levels in healthy postmenopausal women. J Endocrinol Invest 2003; 26: 1225 ‐ 1230. | en_US |
dc.identifier.citedreference | Isidori AM, Strollo F, Morè M et al. Leptin and aging: correlation with endocrine changes in male and female healthy adult populations of different body weights. J Clin Endocrinol Metab 2000; 85: 1954 ‐ 1962. | en_US |
dc.identifier.citedreference | Chan JL, Blüher S, Yiannakouris N et al. Regulation of circulating soluble leptin receptor levels by gender, adiposity, sex steroids, and leptin: observational and interventional studies in humans. Diabetes 2002; 51: 2105 ‐ 2112. | en_US |
dc.identifier.citedreference | Fain JN, Madan AK, Hiler ML, Cheema P, Bahouth SW. Comparison of the release of adipokines by adipose tissue, adipose tissue matrix, and adipocytes from visceral and subcutaneous abdominal adipose tissues of obese humans. Endocrinology 2004; 145: 2273 ‐ 2282. | en_US |
dc.identifier.citedreference | Fisher FM, McTernan PG, Valsamakis G et al. Differences in adiponectin protein expression: effect of fat depots and type 2 diabetic status. Horm Metab Res 2002; 34: 650 ‐ 654. | en_US |
dc.identifier.citedreference | Xu A, Chan KW, Hoo RL et al. Testosterone selectively reduces the high molecular weight form of adiponectin by inhibiting its secretion from adipocytes. J Biol Chem 2005; 280: 18073 ‐ 18080. | en_US |
dc.identifier.citedreference | Wabitsch M, Blum WF, Muche R et al. Contribution of androgens to the gender difference in leptin production in obese children and adolescents. J Clin Invest 1997; 100: 808 ‐ 813. | en_US |
dc.identifier.citedreference | Catalano S, Marsico S, Giordano C et al. Leptin enhances, via AP‐1, expression of aromatase in the MCF‐7 cell line. J Biol Chem 2003; 278: 28668 ‐ 28676. | en_US |
dc.identifier.citedreference | Civitarese AE, Jenkinson CP, Richardson D et al. Adiponectin receptors gene expression and insulin sensitivity in non‐diabetic Mexican Americans with or without a family history of Type 2 diabetes. Diabetologia 2004; 47: 816 ‐ 820. | en_US |
dc.identifier.citedreference | Wildman RP. Healthy obesity. Curr Opin Clin Nutr Metab Care 2009; 12: 438 ‐ 443. | en_US |
dc.identifier.citedreference | Moschos S, Chan JL, Mantzoros CS. Leptin and reproduction: a review. Fertil Steril 2002; 77: 433 ‐ 444. | en_US |
dc.identifier.citedreference | Cnop M, Havel PJ, Utzschneider KM et al. Relationship of adiponectin to body fat distribution, insulin sensitivity and plasma lipoproteins: evidence for independent roles of age and sex. Diabetologia 2003; 46: 459 ‐ 469. | en_US |
dc.identifier.citedreference | Rosenbaum M, Nicolson M, Hirsch J et al. Effects of gender, body composition, and menopause on plasma concentrations of leptin. J Clin Endocrinol Metab 1996; 81: 3424 ‐ 3427. | en_US |
dc.identifier.citedreference | Page ST, Herbst KL, Amory JK et al. Testosterone administration suppresses adiponectin levels in men. J Androl 2005; 26: 85 ‐ 92. | en_US |
dc.identifier.citedreference | Sih R, Morley JE, Kaiser FE et al. Testosterone replacement in older hypogonadal men: a 12‐month randomized controlled trial. J Clin Endocrinol Metab 1997; 82: 1661 ‐ 1667. | en_US |
dc.identifier.citedreference | Remsberg KE, Talbott EO, Zborowski JV, Evans RW, McHugh‐Pemu K. Evidence for competing effects of body mass, hyperinsulinemia, insulin resistance, and androgens on leptin levels among lean, overweight, and obese women with polycystic ovary syndrome. Fertil Steril 2002; 78: 479 ‐ 486. | en_US |
dc.identifier.citedreference | Toulis KA, Goulis DG, Farmakiotis D et al. Adiponectin levels in women with polycystic ovary syndrome: a systematic review and a meta‐analysis. Hum Reprod Update 2009; 15: 297 ‐ 307. | en_US |
dc.identifier.citedreference | Söderberg S, Olsson T, Eliasson M et al. A strong association between biologically active testosterone and leptin in non‐obese men and women is lost with increasing (central) adiposity. Int J Obes Relat Metab Disord 2001; 25: 98 ‐ 105. | en_US |
dc.identifier.citedreference | O'Connor A, Phelan N, Tun TK et al. High‐molecular‐weight adiponectin is selectively reduced in women with polycystic ovary syndrome independent of body mass index and severity of insulin resistance. J Clin Endocrinol Metab 2010; 95: 1378 ‐ 1385. | en_US |
dc.identifier.citedreference | Alexander C, Cochran CJ, Gallicchio L et al. Serum leptin levels, hormone levels, and hot flashes in midlife women. Fertil Steril 2010; 94: 1037 ‐ 1043. | en_US |
dc.identifier.citedreference | Sowers MF, Crawford S, Sternfeld B et al. Design, survey sampling and recruitment methods of SWAN: a multi‐ceter, multi‐ethnic community‐based cohort study of women and the menopausal transition. In: Lobos R, Marcus R, Kelsey JL (eds). Menopause: Biology and Pathobiology. Academic Press: San Diego; 2000, pp 175 ‐ 88. | en_US |
dc.identifier.citedreference | Lukaski HC, Bolonchuk WW. Estimation of body fluid volumes using tetrapolar bioelectrical impedance measurements. Aviat Space Environ Med 1988; 59: 1163 ‐ 1169. | en_US |
dc.identifier.citedreference | Boulier A, Fricker J, Thomasset AL, Apfelbaum M. Fat‐free mass estimation by the two‐electrode impedance method. Am J Clin Nutr 1990; 52: 581 ‐ 585. | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.