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A novel canine model for prostate cancer

dc.contributor.authorKeller, Jill M.en_US
dc.contributor.authorSchade, George R.en_US
dc.contributor.authorIves, Kimberlyen_US
dc.contributor.authorCheng, Xuen_US
dc.contributor.authorRosol, Thomas J.en_US
dc.contributor.authorPiert, Moranden_US
dc.contributor.authorSiddiqui, Javeden_US
dc.contributor.authorRoberts, William W.en_US
dc.contributor.authorKeller, Evan T.en_US
dc.date.accessioned2013-06-18T18:33:19Z
dc.date.available2014-08-01T19:11:34Zen_US
dc.date.issued2013-06en_US
dc.identifier.citationKeller, Jill M.; Schade, George R.; Ives, Kimberly; Cheng, Xu; Rosol, Thomas J.; Piert, Morand; Siddiqui, Javed; Roberts, William W.; Keller, Evan T. (2013). "A novel canine model for prostate cancer." The Prostate 73(9): 952-959. <http://hdl.handle.net/2027.42/98364>en_US
dc.identifier.issn0270-4137en_US
dc.identifier.issn1097-0045en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/98364
dc.description.abstractBACKGROUND No existing animal model fully recapitulates all features of human prostate cancer. The dog is the only large mammal, besides humans, that commonly develops spontaneous prostate cancer. Canine prostate cancer features many similarities with its human counterpart. We sought to develop a canine model of prostate cancer that would more fully represent the features of human prostate cancer than existing models. METHODS The Ace‐1 canine prostate cancer cell line was injected transabdominally under transrectal ultrasound (TRUS) guidance into the prostates of immunosuppressed, intact, adult male dogs. Tumor progression was monitored by TRUS imaging. Some dogs were subjected to positron emission tomography (PET) for tumor detection. Time of euthanasia was determined based on tumor size, impingement on urethra, and general well‐being. Euthanasia was followed by necropsy and histopathology. RESULTS Ace‐1 tumor cells grew robustly in every dog injected. Tumors grew in subcapsular and parenchymal regions of the prostate. Tumor tissue could be identified using PET. Histological findings were similar to those observed in human prostate cancer. Metastases to lungs and lymph nodes were detected, predominantly in dogs with intraprostatic tumors. CONCLUSIONS We have established a minimally invasive dog model of prostate cancer. This model may be valuable for studying prostate cancer progression and distant metastasis. Prostate 73: 952–959, 2013. © 2013 Wiley Periodicals, Inc.en_US
dc.publisherWiley Subscription Services, Inc., A Wiley Companyen_US
dc.subject.otherProstate Canceren_US
dc.subject.otherAnimal Modelen_US
dc.subject.otherMetastasisen_US
dc.subject.otherDogen_US
dc.titleA novel canine model for prostate canceren_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelInternal Medicine and Specialtiesen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Urology, University of Michigan, Rm. 5308 Cancer Center, Ann Arbor, MI 48109‐5940.en_US
dc.contributor.affiliationumDepartment of Urology, University of Michigan, Ann Arbor, Michiganen_US
dc.contributor.affiliationumDepartment of Radiology, University of Michigan, Ann Arbor, Michiganen_US
dc.contributor.affiliationumCenter for Translational Pathology, University of Michigan, Ann Arbor, Michiganen_US
dc.contributor.affiliationotherDepartment of Veterinary Biosciences, The Ohio State University, Columbus, Ohioen_US
dc.identifier.pmid23335024en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/98364/1/22642_ftp.pdf
dc.identifier.doi10.1002/pros.22642en_US
dc.identifier.sourceThe Prostateen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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