Obesity‐induced diabetes and lower urinary tract fibrosis promote urinary voiding dysfunction in a mouse model
dc.contributor.author | Gharaee‐kermani, Mehrnaz | en_US |
dc.contributor.author | Rodriguez‐nieves, Jose A. | en_US |
dc.contributor.author | Mehra, Rohit | en_US |
dc.contributor.author | Vezina, Chad A. | en_US |
dc.contributor.author | Sarma, Aruna V. | en_US |
dc.contributor.author | Macoska, Jill A. | en_US |
dc.date.accessioned | 2013-06-18T18:33:20Z | |
dc.date.available | 2014-09-02T14:12:52Z | en_US |
dc.date.issued | 2013-07 | en_US |
dc.identifier.citation | Gharaee‐kermani, Mehrnaz ; Rodriguez‐nieves, Jose A. ; Mehra, Rohit; Vezina, Chad A.; Sarma, Aruna V.; Macoska, Jill A. (2013). "Obesityâ induced diabetes and lower urinary tract fibrosis promote urinary voiding dysfunction in a mouse model." The Prostate 73(10): 1123-1133. <http://hdl.handle.net/2027.42/98367> | en_US |
dc.identifier.issn | 0270-4137 | en_US |
dc.identifier.issn | 1097-0045 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/98367 | |
dc.description.abstract | BACKGROUND Progressive aging‐ and inflammation‐associated fibrosis effectively remodels the extracellular matrix (ECM) to increase prostate tissue stiffness and reduce urethral flexibility, resulting in urinary flow obstruction and lower urinary tract symptoms (LUTS). In the current study, we sought to test whether senescence‐accelerated mouse prone (SAMP)6 mice, which were reported to develop prostatic fibrosis, would also develop LUTS, and whether these symptoms would be exacerbated by diet‐induced obesity and concurrent Type 2 Diabetes Mellitus (T2DM). METHODS To accomplish this, SAMP6 and AKR/J background strain mice were fed regular mouse chow, low fat diet chow, or high fat diet chow for 8 months, then subjected to glucose tolerance tests, assessed for plasma insulin levels, evaluated for urinary voiding function, and assessed for lower urinary tract fibrosis. RESULTS The results of these studies show that SAMP6 mice and AKR/J background strain mice develop diet‐induced obesity and T2DM concurrent with urinary voiding dysfunction. Moreover, urinary voiding dysfunction was more severe in SAMP6 than AKR/J mice and was associated with pronounced prostatic and urethral tissue fibrosis. CONCLUSIONS Taken together, these studies suggest that obesity, T2DM, lower urinary tract fibrosis, and urinary voiding dysfunction are inextricably and biologically linked. Prostate 73: 1123–1133, 2013. © 2013 Wiley Periodicals, Inc. | en_US |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Diet | en_US |
dc.subject.other | Fat | en_US |
dc.subject.other | Prostate | en_US |
dc.subject.other | Bladder | en_US |
dc.subject.other | Collagen | en_US |
dc.title | Obesity‐induced diabetes and lower urinary tract fibrosis promote urinary voiding dysfunction in a mouse model | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Urology, The University of Michigan, 6217 Cancer Center, 1500 East Medical Center Drive, Ann Arbor, MI 48109‐0944. | en_US |
dc.contributor.affiliationum | The Department of Urology, The University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | The Graduate Program in Cellular and Molecular Biology, The University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | The Department of Pathology, The University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationother | The Department of Comparative Biosciences, The University of Wisconsin, Madison, Wisconsin | en_US |
dc.identifier.pmid | 23532836 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/98367/1/22662_ftp.pdf | |
dc.identifier.doi | 10.1002/pros.22662 | en_US |
dc.identifier.source | The Prostate | en_US |
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dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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