Prediction of Therapy Tumor-Absorbed Dose Estimates in I-131 Radioimmunotherapy Using Tracer Data Via a Mixed-Model Fit to Time Activity
dc.contributor.author | Schipper, Matthew J. | en_US |
dc.contributor.author | Koral, Kenneth F. | en_US |
dc.contributor.author | Avram, Anca M. | en_US |
dc.contributor.author | Kaminski, Mark S. | en_US |
dc.contributor.author | Dewaraja, Yuni K. | en_US |
dc.date.accessioned | 2013-06-25T18:43:10Z | |
dc.date.available | 2013-06-25T18:43:10Z | |
dc.date.issued | 2012-09 | en_US |
dc.identifier.citation | Schipper, Matthew J.; Koral, Kenneth F.; Avram, Anca M.; Kaminski, Mark S.; Dewaraja, Yuni K. (2012). "Prediction of Therapy Tumor-Absorbed Dose Estimates in I-131 Radioimmunotherapy Using Tracer Data Via a Mixed-Model Fit to Time Activity." Cancer Biotherapy & Radiopharmaceuticals 27(7): 403-411. <http://hdl.handle.net/2027.42/98438> | en_US |
dc.identifier.issn | 1084-9785 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/98438 | |
dc.description.abstract | Abstract Background: For individualized treatment planning in radioimmunotherapy (RIT), correlations must be established between tracer-predicted and therapy-delivered absorbed doses. The focus of this work was to investigate this correlation for tumors. Methods: The study analyzed 57 tumors in 19 follicular lymphoma patients treated with I-131 tositumomab and imaged with SPECT/CT multiple times after tracer and therapy administrations. Instead of the typical least-squares fit to a single tumor's measured time-activity data, estimation was accomplished via a biexponential mixed model in which the curves from multiple subjects were jointly estimated. The tumor-absorbed dose estimates were determined by patient-specific Monte Carlo calculation. Results: The mixed model gave realistic tumor time-activity fits that showed the expected uptake and clearance phases even with noisy data or missing time points. Correlation between tracer and therapy tumor-residence times (r=0.98; p<0.0001) and correlation between tracer-predicted and therapy-delivered mean tumor-absorbed doses (r=0.86; p<0.0001) were very high. The predicted and delivered absorbed doses were within±25% (or within±75 cGy) for 80% of tumors. Conclusions: The mixed-model approach is feasible for fitting tumor time-activity data in RIT treatment planning when individual least-squares fitting is not possible due to inadequate sampling points. The good correlation between predicted and delivered tumor doses demonstrates the potential of using a pretherapy tracer study for tumor dosimetry-based treatment planning in RIT. | en_US |
dc.publisher | Mary Ann Liebert, Inc., publishers | en_US |
dc.title | Prediction of Therapy Tumor-Absorbed Dose Estimates in I-131 Radioimmunotherapy Using Tracer Data Via a Mixed-Model Fit to Time Activity | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Medicine (General) | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.identifier.pmid | 22947086 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/98438/1/cbr%2E2011%2E1053.pdf | |
dc.identifier.doi | 10.1089/cbr.2011.1053 | en_US |
dc.identifier.source | Cancer Biotherapy & Radiopharmaceuticals | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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