Predictors of cardiac allograft vasculopathy in pediatric heart transplant recipients
dc.contributor.author | Kobayashi, Daisuke | en_US |
dc.contributor.author | Du, Wei | en_US |
dc.contributor.author | L'Ecuyer, Thomas J. | en_US |
dc.date.accessioned | 2013-07-08T17:45:41Z | |
dc.date.available | 2014-10-06T19:17:43Z | en_US |
dc.date.issued | 2013-08 | en_US |
dc.identifier.citation | Kobayashi, Daisuke; Du, Wei; L'Ecuyer, Thomas J. (2013). "Predictors of cardiac allograft vasculopathy in pediatric heart transplant recipients." Pediatric Transplantation 17(5): 436-440. <http://hdl.handle.net/2027.42/98807> | en_US |
dc.identifier.issn | 1397-3142 | en_US |
dc.identifier.issn | 1399-3046 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/98807 | |
dc.description.abstract | CAV remains a leading cause of late graft loss and mortality among survivors of pediatric heart transplantation. We sought to define the incidence of CAV and identify its predictors in pediatric heart transplant recipients. The OPTN / UNOS database was analyzed for pediatric recipients who underwent heart transplant between 1987 and 2011. The primary end‐point is time from heart transplantation to development of CAV ( CAV ‐free survival). To identify predictors of CAV ‐free survival, demographic and transplant data were analyzed by the K aplan– M eier survival method and C ox proportional hazards regression. Of 5211 pediatric heart transplant recipients with at least one‐yr follow‐up, the incidence of CAV at five, 10, and 15 yr was 13%, 25%, and 54%, respectively. Multivariate analysis found that risk of CAV was associated with the following variables: Recipient age 1–4 yr (HR 1.25), 5–9 yr (1.45), 10–18 yr (1.83), donor age >18 yr (1.34), re‐transplantation (2.14), recipient black race (1.55), and donor cigarette use (1.54). Older recipient and donor age, recipient black race, donor cigarette use, and re‐transplantation were highly associated with shorter CAV ‐free survival. | en_US |
dc.publisher | Wiley Periodicals, Inc. | en_US |
dc.subject.other | Cardiac Allograft Vasculopathy | en_US |
dc.subject.other | Children | en_US |
dc.subject.other | Predictor | en_US |
dc.subject.other | Orthotopic Heart Transplant | en_US |
dc.title | Predictors of cardiac allograft vasculopathy in pediatric heart transplant recipients | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Pediatrics | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.identifier.pmid | 23714284 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/98807/1/petr12095.pdf | |
dc.identifier.doi | 10.1111/petr.12095 | en_US |
dc.identifier.source | Pediatric Transplantation | en_US |
dc.identifier.citedreference | Singh TP, Almond CS, Gauvreau K. Improved survival in pediatric heart transplant recipients: Have white, black and Hispanic children benefited equally? Am J Transplant 2011: 11: 120 – 128. | en_US |
dc.identifier.citedreference | Colvin‐Adams M, Agnihotri A. Cardiac allograft vasculopathy: Current knowledge and future direction. Clin Transplant 2011: 25: 175 – 184. | en_US |
dc.identifier.citedreference | Schumacher KR, Gajarski RJ, Urschel S. Pediatric coronary allograft vasculopathy – a review of pathogenesis and risk factors. Congenit Heart Dis 2012: 7: 312 – 323. | en_US |
dc.identifier.citedreference | Kirk R, Edwards LB, Kucheryavaya AY, et al. The Registry of the International Society for Heart and Lung Transplantation: Thirteenth official pediatric heart transplantation report–2010. J Heart Lung Transplant 2010: 29: 1119 – 1128. | en_US |
dc.identifier.citedreference | Pahl E, Naftel DC, Kuhn MA, et al. The impact and outcome of transplant coronary artery disease in a pediatric population: A 9‐year multi‐institutional study. J Heart Lung Transplant 2005: 24: 645 – 651. | en_US |
dc.identifier.citedreference | United Network of Organ Sharing (UNOS) website. Available at: http://www.unos.org/ (accessed March 20, 2012) | en_US |
dc.identifier.citedreference | Mahle WT, Kanter KR, Vincent RN. Disparities in outcome for black patients after pediatric heart transplantation. J Pediatr 2005: 147: 739 – 743. | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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