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Pediatric case of mesalazine‐induced interstitial nephritis with literature review
dc.contributor.authorCo, Maridine L.en_US
dc.contributor.authorGorospe, Emmanuel C.en_US
dc.date.accessioned2013-07-08T17:45:46Z
dc.date.available2014-08-01T19:11:40Zen_US
dc.date.issued2013-06en_US
dc.identifier.citationCo, Maridine L.; Gorospe, Emmanuel C. (2013). "Pediatric case of mesalazine‐induced interstitial nephritis with literature review." Pediatrics International (3): 385-387. <http://hdl.handle.net/2027.42/98820>en_US
dc.identifier.issn1328-8067en_US
dc.identifier.issn1442-200Xen_US
dc.identifier.urihttps://hdl.handle.net/2027.42/98820
dc.description.abstractWe present the case of a 14‐year‐old boy with ulcerative colitis who was diagnosed with mesalazine‐induced interstitial nephritis ( M‐IIN ). Improvement in renal function occurred with discontinuation of mesalazine and corticosteroid therapy. We systematically searched the literature for pediatric cases of M‐IIN . There were eight cases. Majority of the cases were boys (75%) with ulcerative colitis (75%). Average duration of mesalazine use prior to the diagnosis of interstitial nephritis was 24 ± 18 months. The median dose was 1.5 g/day. M‐IIN appears to be an idiosyncratic reaction without any relation to dose or duration of mesalazine use. Although there are no guidelines to recommend routine surveillance of renal function, monitoring of serum creatinine in patients on mesalazine remains an inexpensive and non‐invasive test that may lead to early detection and treatment of renal injury.en_US
dc.publisherWiley Periodicals, Inc.en_US
dc.subject.otherMesalazineen_US
dc.subject.otherInflammatory Bowel Diseaseen_US
dc.subject.otherInterstitial Nephritisen_US
dc.titlePediatric case of mesalazine‐induced interstitial nephritis with literature reviewen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPediatricsen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.identifier.pmid23782372en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/98820/1/ped3745.pdf
dc.identifier.doi10.1111/j.1442-200X.2012.03745.xen_US
dc.identifier.sourcePediatrics Internationalen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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