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Prevalence and predictive role of p16 and epidermal growth factor receptor in surgically treated oropharyngeal and oral cavity cancer
dc.contributor.authorChandarana, Shamir P.en_US
dc.contributor.authorLee, Julia S.en_US
dc.contributor.authorChanowski, Eric J. P.en_US
dc.contributor.authorSacco, Assuntina G.en_US
dc.contributor.authorBradford, Carol R.en_US
dc.contributor.authorWolf, Gregory T.en_US
dc.contributor.authorPrince, Mark E.en_US
dc.contributor.authorMoyer, Jeffrey S.en_US
dc.contributor.authorEisbruch, Avrahamen_US
dc.contributor.authorWorden, Francis P.en_US
dc.contributor.authorGiordano, Thomas J.en_US
dc.contributor.authorKumar, Bhavnaen_US
dc.contributor.authorCordell, Katrina G.en_US
dc.contributor.authorCarey, Thomas E.en_US
dc.contributor.authorChepeha, Douglas B.en_US
dc.date.accessioned2013-08-02T20:51:25Z
dc.date.available2014-10-06T19:17:44Zen_US
dc.date.issued2013-08en_US
dc.identifier.citationChandarana, Shamir P.; Lee, Julia S.; Chanowski, Eric J. P.; Sacco, Assuntina G.; Bradford, Carol R.; Wolf, Gregory T.; Prince, Mark E.; Moyer, Jeffrey S.; Eisbruch, Avraham; Worden, Francis P.; Giordano, Thomas J.; Kumar, Bhavna; Cordell, Katrina G.; Carey, Thomas E.; Chepeha, Douglas B. (2013). "Prevalence and predictive role of p16 and epidermal growth factor receptor in surgically treated oropharyngeal and oral cavity cancer." Head & Neck 35(8): 1083-1090. <http://hdl.handle.net/2027.42/99017>en_US
dc.identifier.issn1043-3074en_US
dc.identifier.issn1097-0347en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/99017
dc.description.abstractBackground The purpose of this study was to describe the relationship of p16 and epidermal growth factor receptor (EGFR) expression with survival in surgically treated patients who had oropharyngeal or oral cavity squamous cell carcinoma (SCC). Methods Tissue from 36 patients with oropharyngeal SCC and 49 patients with oral cavity SCC treated between 1997 and 2001 was imbedded and immunostained using a tissue microarray. Results The p16 was positive in 57% and 13% of patients with oropharyngeal SCC and oral cavity SCC, respectively. EGFR was positive in 60% and 63% of patients with oropharyngeal SCC and oral cavity SCC, respectively. In patients with oropharyngeal SCC, p16 expression was associated with improved disease‐specific survival (DSS), overall survival (OS), and time to recurrence (TTR) ( p < .01, < .01, and <.01, respectively). EGFR expression was associated with poorer DSS, OS, and TTR ( p < .01, = .01, and < .01, respectively). For oropharyngeal SCC, when examining both p16 and EGFR expression as combined biomarkers, high p16 expression coupled with low EGFR expression was associated with improved DSS ( p p16 = .01; p EGFR = .01). Patients with oral cavity SCC showed no association between biomarker and outcome. Conclusions For patients with oropharyngeal SCC, high p16 and low EGFR were associated with improved outcome, suggesting a predictive role in surgically treated patients. © 2012 Wiley Periodicals, Inc. Head Neck, 2013en_US
dc.publisherWiley Subscription Services, Inc., A Wiley Companyen_US
dc.subject.otherOral Cavity Neoplasmen_US
dc.subject.otherP16(INK4A)en_US
dc.subject.otherEGFR Proteinen_US
dc.subject.otherHuman Papillomavirusen_US
dc.subject.otherOropharyngeal Neoplasmen_US
dc.titlePrevalence and predictive role of p16 and epidermal growth factor receptor in surgically treated oropharyngeal and oral cavity canceren_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelOtolaryngologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Otolaryngology—Head and Neck Surgery, University of Michigan Health, System, Ann Arbor, Michiganen_US
dc.contributor.affiliationumInstitute for Social Research, University of Michigan, Ann Arbor, Michiganen_US
dc.contributor.affiliationumDepartment of Radiation Oncology, University of Michigan Health System, Ann Arbor, Michiganen_US
dc.contributor.affiliationumDepartment of Internal Medicine—Hematology/Oncology, University of Michigan Health System, Ann Arbor, Michiganen_US
dc.contributor.affiliationumDepartments of Pathology and Internal Medicine, University of Michigan Health System, Ann Arbor, Michiganen_US
dc.contributor.affiliationumDepartment of Otolaryngology—Head and Neck Surgery, University of Michigan Health System, 1904 Taubman Center, 1500 E. Medical Center Drive, Ann Arbor, MI 48109‐0312en_US
dc.contributor.affiliationotherDivision of Otolaryngology—Head and Neck Surgery, University of Calgary, Foothills Medical Centre, Calgary, Alberta, Canadaen_US
dc.contributor.affiliationotherDepartment of Internal Medicine, Loyola University Medical Center, Maywood, Illinoisen_US
dc.contributor.affiliationotherDepartment of Otolaryngology—Head and Neck Surgery, The Ohio State University, Columbus, Ohioen_US
dc.contributor.affiliationotherDepartment of Oral and Maxillofacial Pathology, Louisiana State University Health Sciences Center, New Orleans, Louisianaen_US
dc.identifier.pmid22907805en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/99017/1/23087_ftp.pdf
dc.identifier.doi10.1002/hed.23087en_US
dc.identifier.sourceHead & Necken_US
dc.identifier.citedreferencePreuss SF, Weinell A, Molitor M, et al. Survivin and epidermal growth factor receptor expression in surgically treated oropharyngeal squamous cell carcinoma. Head Neck 2008; 30: 1318 – 1324.en_US
dc.identifier.citedreferenceSmid EJ, Stoter TR, Bloemena E, et al. The importance of immunohistochemical expression of EGFr in squamous cell carcinoma of the oral cavity treated with surgery and postoperative radiotherapy. Int J Radiat Oncol Biol Phys 2006; 65: 1323 – 1329.en_US
dc.identifier.citedreferenceDassonville O, Formento JL, Francoual M, et al. Expression of epidermal growth factor receptor and survival in upper aerodigestive tract cancer. J Clin Oncol 1993; 11: 1873 – 1878.en_US
dc.identifier.citedreferenceHerrero R, Castellsagué X, Pawlita M, et al. Human papillomavirus and oral cancer: the International Agency for Research on Cancer multicenter study. J Natl Cancer Inst 2003; 95: 1772 – 1783.en_US
dc.identifier.citedreferenceRitchie JM, Smith EM, Summersgill KF, et al. Human papillomavirus infection as a prognostic factor in carcinomas of the oral cavity and oropharynx. Int J Cancer 2003; 104: 336 – 344.en_US
dc.identifier.citedreferenceUkpo OC, Pritchett CV, Lewis JE, Weaver AL, Smith DI, Moore EJ. Human papillomavirus‐associated oropharyngeal squamous cell carcinomas: primary tumor burden and survival in surgical patients. Ann Otol Rhinol Laryngol 2009; 118: 368 – 373.en_US
dc.identifier.citedreferenceBentzen SM, Atasoy BM, Daley FM, et al. Epidermal growth factor receptor expression in pretreatment biopsies from head and neck squamous cell carcinoma as a predictive factor for a benefit from accelerated radiation therapy in a randomized controlled trial. J Clin Oncol 2005; 23: 5560 – 5567.en_US
dc.identifier.citedreferenceLicitra L, Perrone F, Bossi P, et al. High‐risk human papillomavirus affects prognosis in patients with surgically treated oropharyngeal squamous cell carcinoma. J Clin Oncol 2006; 24: 5630 – 5636.en_US
dc.identifier.citedreferenceReimers N, Kasper HU, Weissenborn SJ, et al. Combined analysis of HPV‐DNA, p16 and EGFR expression to predict prognosis in oropharyngeal cancer. Int J Cancer 2007; 120: 1731 – 1738.en_US
dc.identifier.citedreferenceChung CH, Gillison ML. Human papillomavirus in head and neck cancer: its role in pathogenesis and clinical implications. Clin Cancer Res 2009; 15: 6758 – 6762.en_US
dc.identifier.citedreferenceKumar B, Cordell KG, Lee JS, et al. EGFR, p16, HPV titer, Bcl‐xL and p53, sex, and smoking as indicators of response to therapy and survival in oropharyngeal cancer. J Clin Oncol 2008; 26: 3128 – 3137.en_US
dc.identifier.citedreferenceHaughey BH, Hinni ML, Salassa JR, et al. Transoral laser microsurgery as primary treatment for advanced‐stage oropharyngeal cancer: a United States multicenter study. Head Neck 2011; 33: 1683 – 1694.en_US
dc.identifier.citedreferenceRich JT, Milov S, Lewis JS Jr, Thorstad WL, Adkins DR, Haughey BH. Transoral laser microsurgery (TLM) +/− adjuvant therapy for advanced stage oropharyngeal cancer: outcomes and prognostic factors. Laryngoscope 2009; 119: 1709 – 1719.en_US
dc.identifier.citedreferenceNichols AC, Faquin WC, Westra WH, et al. HPV‐16 infection predicts treatment outcome in oropharyngeal squamous cell carcinoma. Otolaryngol Head Neck Surg 2009; 140: 228 – 234.en_US
dc.identifier.citedreferenceChung CH, Ely K, McGavran L, et al. Increased epidermal growth factor receptor gene copy number is associated with poor prognosis in head and neck squamous cell carcinomas. J Clin Oncol 2006; 24: 4170 – 4176.en_US
dc.identifier.citedreferenceAng KK, Harris J, Wheeler R, et al. Human papillomavirus and survival of patients with oropharyngeal cancer. N Engl J Med 2010; 363: 24 – 35.en_US
dc.identifier.citedreferenceLassen P, Eriksen JG, Hamilton–Dutoit S, Tramm T, Alsner J, Overgaard J. Effect of HPV‐associated p16INK4A expression on response to radiotherapy and survival in squamous cell carcinoma of the head and neck. J Clin Oncol 2009; 27: 1992 – 1998.en_US
dc.identifier.citedreferenceRingström E, Peters E, Hasegawa M, Posner M, Liu M, Kelsey KT. Human papillomavirus type 16 and squamous cell carcinoma of the head and neck. Clin Cancer Res 2002; 8: 3187 – 3192.en_US
dc.identifier.citedreferenceGillison ML, Koch WM, Capone RB, et al. Evidence for a causal association between human papillomavirus and a subset of head and neck cancers. J Natl Cancer Inst 2000; 92: 709 – 720.en_US
dc.identifier.citedreferenceKong CS, Narasimhan B, Cao H, et al. The relationship between human papillomavirus status and other molecular prognostic markers in head and neck squamous cell carcinomas. Int J Radiat Oncol Biol Phys 2009; 74: 553 – 561.en_US
dc.identifier.citedreferenceWorden FP, Kumar B, Lee JS, et al. Chemoselection as a strategy for organ preservation in advanced oropharynx cancer: response and survival positively associated with HPV16 copy number. J Clin Oncol 2008; 26: 3138 – 3146.en_US
dc.identifier.citedreferenceAng KK, Berkey BA, Tu X, et al. Impact of epidermal growth factor receptor expression on survival and pattern of relapse in patients with advanced head and neck carcinoma. Cancer Res 2002; 62: 7350 – 7356.en_US
dc.identifier.citedreferenceNumico G, Russi EG, Colantonio I, et al. EGFR status and prognosis of patients with locally advanced head and neck cancer treated with chemoradiotherapy. Anticancer Res 2010; 30: 671 – 676.en_US
dc.identifier.citedreferenceMaxwell JH, Kumar B, Feng FY, et al. Tobacco use in human papillomavirus‐positive advanced oropharynx cancer patients related to increased risk of distant metastases and tumor recurrence. Clin Cancer Res 2010; 16: 1226 – 1235.en_US
dc.identifier.citedreferenceKalyankrishna S, Grandis JR. Epidermal growth factor receptor biology in head and neck cancer. J Clin Oncol 2006; 24: 2666 – 2672.en_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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