BDNF Val 66 Met genotype is associated with drug‐seeking phenotypes in heroin‐dependent individuals: a pilot study
dc.contributor.author | Greenwald, Mark K. | en_US |
dc.contributor.author | Steinmiller, Caren L. | en_US |
dc.contributor.author | Śliwerska, Elzbieta | en_US |
dc.contributor.author | Lundahl, Leslie | en_US |
dc.contributor.author | Burmeister, Margit | en_US |
dc.date.accessioned | 2013-09-04T17:18:16Z | |
dc.date.available | 2014-10-06T19:17:41Z | en_US |
dc.date.issued | 2013-09 | en_US |
dc.identifier.citation | Greenwald, Mark K.; Steinmiller, Caren L.; Śliwerska, Elzbieta ; Lundahl, Leslie; Burmeister, Margit (2013). "BDNF Val 66 Met genotype is associated with drugâ seeking phenotypes in heroinâ dependent individuals: a pilot study." Addiction Biology (5): 836-845. <http://hdl.handle.net/2027.42/99593> | en_US |
dc.identifier.issn | 1355-6215 | en_US |
dc.identifier.issn | 1369-1600 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/99593 | |
dc.description.abstract | Brain‐derived neurotrophic factor (BDNF) Val 66 Met genotype has been associated with neurobehavioral deficits. To examine its relevance for addiction, we examined BDNF genotype differences in drug‐seeking behavior. Heroin‐dependent volunteers ( n = 128) completed an interview that assessed past‐month naturalistic drug‐seeking/use behaviors. In African Americans ( n = 74), the Met allele was uncommon (carrier frequency 6.8%); thus, analyses focused on European Americans ( n = 54), in whom the Met allele was common (carrier frequency 37.0%). In their natural setting, Met carriers ( n = 20) reported more time‐ and cost‐intensive heroin‐seeking and more cigarette use than Val homozygotes ( n = 34). BDNF Val 66 Met genotype predicted 18.4% of variance in ‘weekly heroin investment’ (purchasing time × amount × frequency). These data suggest that the BDNF Met allele may confer a ‘preferred drug‐invested’ phenotype, resistant to moderating effects of higher drug prices and non‐drug reinforcement. These preliminary hypothesis‐generating findings require replication, but are consistent with pre‐clinical data that demonstrate neurotrophic influence in drug reinforcement. Whether this genotype is relevant to other abused substances besides opioids or nicotine, or treatment response, remains to be determined. | en_US |
dc.publisher | Blackwell Publishing Ltd | en_US |
dc.publisher | Wiley Periodicals, Inc. | en_US |
dc.subject.other | Opioid. | en_US |
dc.subject.other | Drug‐Seeking | en_US |
dc.subject.other | BDNF | en_US |
dc.subject.other | Cigarette | en_US |
dc.subject.other | Genotype | en_US |
dc.subject.other | Heroin | en_US |
dc.title | BDNF Val 66 Met genotype is associated with drug‐seeking phenotypes in heroin‐dependent individuals: a pilot study | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Neurology and Neurosciences | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Psychiatry, and Molecular & Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationother | Substance Abuse Research Division, Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, USA | en_US |
dc.contributor.affiliationother | Department of Pharmacology, College of Pharmacy and Pharmaceutical Sciences, University of Toledo, Toledo, OH, USA | en_US |
dc.identifier.pmid | 22339949 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/99593/1/adb431.pdf | |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/99593/2/adb431_sm_fig_s1.pdf | |
dc.identifier.doi | 10.1111/j.1369-1600.2011.00431.x | en_US |
dc.identifier.source | Addiction Biology | en_US |
dc.identifier.citedreference | Gerdeman GL, Partridge JG, Lupica CR, Lovinger DM ( 2003 ) It could be habit forming: drugs of abuse and striatal synaptic plasticity. Trends Neurosci 26: 184 – 192. | en_US |
dc.identifier.citedreference | Khokhar JY, Ferguson CS, Zhu AZX, Tyndale RF ( 2010 ) Pharmacogenetics of drug dependence: role of gene variations in susceptibility and treatment. Annu Rev Pharmacol Toxicol 50: 39 – 61. | en_US |
dc.identifier.citedreference | Koob GF, Le Moal M ( 2001 ) Drug addiction, dysregulation of reward, and allostasis. Neuropsychopharmacology 24: 97 – 129. | en_US |
dc.identifier.citedreference | Lang UE, Sander T, Lohoff FW, Hellweg R, Bajbouj M, Winterer G, Gallinat J ( 2007 ) Association of the met66 allele of brain–derived neurotrophic factor (BDNF) with smoking. Psychopharmacology (Berl) 190: 433 – 439. | en_US |
dc.identifier.citedreference | Le Foll B, Diaz J, Sokoloff P ( 2005 ) A single cocaine exposure increases BDNF and D3 receptor expression: implications for drug‐conditioning. Neuroreport 16: 175 – 178. | en_US |
dc.identifier.citedreference | Lerman C, Perkins KA, Gould TJ ( 2009 ) Nicotine‐dependence endophenotypes in chronic smokers. In: Swan GE, Baker TB, Chassin L, Conti DV, Lerman C, Perkins KA, eds. National Cancer Institute. Phenotypes and Endophenotypes: Foundations for Genetic Studies of Nicotine Use and Dependence. Tobacco Control Monograph No. 20, pp. 403 – 484. Bethesda, MD: US Dept. of Health and Human Services, National Institutes of Health, National Cancer Institute. NIH Publication No. 09‐6366. | en_US |
dc.identifier.citedreference | Li MD, Burmeister M ( 2009 ) New insights into the genetics of addiction. Nat Rev Genet 10: 225 – 231. | en_US |
dc.identifier.citedreference | Lipsky RH, Marini AM ( 2007 ) Brain‐derived neurotrophic factor in neuronal survival and behavior‐related plasticity. Ann N Y Acad Sci 1122: 130 – 143. | en_US |
dc.identifier.citedreference | Lu B ( 2003 ) Pro‐region of neurotrophins: role in synaptic modulation. Neuron 39: 735 – 738. | en_US |
dc.identifier.citedreference | Lu L, Dempsey J, Liu SY, Bossert JM, Shaham Y ( 2004 ) A single infusion of brain‐derived neurotrophic factor into the ventral tegmental area induces long‐lasting potentiation of cocaine seeking after withdrawal. J Neurosci 24: 1604 – 1611. | en_US |
dc.identifier.citedreference | Maisonpierre PC, Le Beau MM, Espinosa R III, Ip NY, Belluscio L, de la Monte SM, Squinto S, Furth ME, Yancopoulos GD ( 1991 ) Human and rat brain‐derived neurotrophic factor and neurotrophin‐3: gene structures, distributions, and chromosomal localizations. Genomics 10: 558 – 568. | en_US |
dc.identifier.citedreference | Matsushita S, Kimura M, Miyakawa T, Yoshino A, Murayama M, Masaki T, Higuchi S ( 2004 ) Association study of brain‐derived neurotrophic factor gene polymorphism and alcoholism. Alcohol Clin Exp Res 28: 1609 – 1612. | en_US |
dc.identifier.citedreference | Novak G, LeBlanc M, Zai C, Shaikh S, Renou J, DeLuca V, Bulgin N, Kennedy JL, Le Foll B ( 2010 ) Association of polymorphisms in the BDNF, DRD1 and DRD3 genes with tobacco smoking in schizophrenia. Ann Hum Genet 74: 291 – 298. | en_US |
dc.identifier.citedreference | Numan S, Lane‐Ladd SB, Zhang L, Lundgren KH, Russell DS, Seroogy KB, Nestler EJ ( 1998 ) Differential regulation of neurotrophin and trk receptor mRNAs in catecholaminergic nuclei during chronic opiate treatment and withdrawal. J Neurosci 18: 10700 – 10708. | en_US |
dc.identifier.citedreference | Petryshen TL, Sabeti PC, Aldinger KA, Fry B, Fan JB, Schaffner SF, Waggoner SG, Tahl AR, Sklar P ( 2010 ) Population genetic study of the brain‐derived neurotrophic factor (BDNF) gene. Mol Psychiatry 15: 810 – 815. | en_US |
dc.identifier.citedreference | Pezawas L, Verchinski BA, Mattay VS, Callicott JH, Kolachana BS, Straub RE, Egan MF, Meyer‐Lindenberg A, Weinberger DR ( 2004 ) The brain‐derived neurotrophic factor val66met polymorphism and variation in human cortical morphology. J Neurosci 24: 10099 – 10102. | en_US |
dc.identifier.citedreference | Roddy JK, Greenwald MK ( 2009 ) An economic analysis of income and expenditures in heroin‐using research volunteers. Subst Use Misuse 44: 1503 – 1518. | en_US |
dc.identifier.citedreference | Roddy JK, Steinmiller CL, Greenwald MK ( 2011 ) Heroin purchasing is income‐ and price‐sensitive. Psychol Addict Behav 25: 358 – 364. | en_US |
dc.identifier.citedreference | Russo SJ, Mazei‐Robison MS, Ables JL, Nestler EJ ( 2009 ) Neurotrophic factors and structural plasticity in addiction. Neuropharmacology 56: 73 – 82. | en_US |
dc.identifier.citedreference | Saccone NL, Saccone SF, Hinrichs AL, Stitzel JA, Duan W, Pergadia ML, Agrawal A, Breslau N, Grucza RA, Hatsukami D, Johnson EO, Madden PA, Swan GE, Wang JC, Goate AM, Rice JP, Bierut LJ ( 2009 ) Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes. Am J Med Genet B Neuropsychiatr Genet 150B: 453 – 466. | en_US |
dc.identifier.citedreference | Sklair‐Tavron L, Shi W‐X, Lane SB, Harris HW, Bunney BS, Nestler EJ ( 1996 ) Chronic morphine induces visible changes in the morphology of mesolimbic dopamine neurons. Proc Natl Acad Sci U S A 93: 11202 – 11207. | en_US |
dc.identifier.citedreference | Sokoloff P, Diaz J, Le Foll B, Guillin O, Leriche L, Bezard E, Gross C ( 2006 ) The dopamine D3 receptor: a therapeutic target for the treatment of neuropsychiatric disorders. CNS Neurol Disord Drug Targets 5: 25 – 43. | en_US |
dc.identifier.citedreference | Szeszko PR, Lipsky R, Mentschel C, Robinson D, Gunduz‐Bruce H, Sevy S, Ashtari M, Napolitano B, Bilder RM, Kane JM, Goldman D, Malhotra AK ( 2005 ) Brain‐derived neurotrophic factor val66met polymorphism and volume of the hippocampal formation. Mol Psychiatry 10: 631 – 636. | en_US |
dc.identifier.citedreference | The Tobacco and Genetics Consortium ( 2010 ) Genome‐wide meta‐analyses identify multiple loci associated with smoking behavior. Nat Genet 42: 441 – 447. | en_US |
dc.identifier.citedreference | Vanderschuren LJMJ, Kalivas PW ( 2000 ) Alterations in dopaminergic and glutamatergic transmission in the induction and expression of behavioral sensitization: a critical review of preclinical studies. Psychopharmacology (Berl) 151: 99 – 120. | en_US |
dc.identifier.citedreference | Vargas‐Perez H, Kee RT‐A, Walton CH, Hansen DM, Razavi R, Clarke L, Bufalino MR, Allison DW, Steffensen SC, van der Kooy D ( 2009 ) Ventral tegmental area BDNF induces an opiate‐dependent‐like reward state in naïve rats. Science 324: 1732 – 1734. | en_US |
dc.identifier.citedreference | Wojnar M, Brower KJ, Strobbe S, Ilgen M, Matsumoto H, Nowosad I, Sliwerska E, Burmeister M ( 2009 ) Association between Val66Met brain‐derived neurotrophic factor (BDNF) gene polymorphism and post‐treatment relapse in alcohol dependence. Alcohol Clin Exp Res 33: 1 – 10. | en_US |
dc.identifier.citedreference | Wong CCY, Schumann G ( 2008 ) Genetics of addictions: strategies for addressing heterogeneity and polygenicity of substance use disorders. Philos Trans R Soc Lond B Biol Sci 363: 3213 – 3222. | en_US |
dc.identifier.citedreference | Yuferov V, Levran O, Proudnikov D, Nielsen DA, Kreek MJ ( 2010 ) Search for genetic markers and functional variants involved in the development of opiate and cocaine addiction and treatment. Ann N Y Acad Sci 1187: 184 – 207. | en_US |
dc.identifier.citedreference | Berhow MT, Russell DS, Terwilliger RZ, Beitner‐Johnson D, Self DW, Lindsay RM, Nestler EJ ( 1995 ) Influence of neurotrophic factors on morphine‐ and cocaine‐induced biochemical changes in the mesolimbic dopamine system. Neuroscience 68: 969 – 979. | en_US |
dc.identifier.citedreference | Beuten J, Ma JZ, Payne TJ, Dupont RT, Quezada P, Huang W, Crews KM, Li MD ( 2005 ) Significant association of BDNF haplotypes in European‐American male smokers but not in European‐American female or African‐American smokers. Am J Med Genet B Neuropsychiatr Genet 139: 73 – 80. | en_US |
dc.identifier.citedreference | Bolanos CA, Nestler EJ ( 2004 ) Neurotrophic mechanisms in drug addiction. Neuromolecular Med 5: 69 – 83. | en_US |
dc.identifier.citedreference | Bueller JA, Aftab M, Sen S, Gomez‐Hassan D, Burmeister M, Zubieta J‐K ( 2006 ) BDNF Val66Met allele is associated with reduced hippocampal volume in healthy subjects. Biol Psychiatry 59: 812 – 815. | en_US |
dc.identifier.citedreference | Carvalho AL, Caldeira MV, Santos SD, Duarte CB ( 2008 ) Role of the brain‐derived neurotrophic factor at glutamatergic synapses. Br J Pharmacol 153 (Suppl 1 ): S310 – S324. | en_US |
dc.identifier.citedreference | Chen ZY, Jing D, Bath KG, Ieraci A, Khan T, Siao CJ, Herrera DG, Toth M, Yang C, McEwen BS, Hempstead BL, Lee FS ( 2006 ) Genetic variant BDNF (Val66Met) polymorphism alters anxiety‐related behavior. Science 314: 140 – 143. | en_US |
dc.identifier.citedreference | Chen ZY, Patel PD, Sant G, Meng CX, Teng KK, Hempstead BL Lee FS ( 2004 ) Variant brain‐derived neurotrophic factor (BDNF) (Met66) alters the intracellular trafficking and activity‐dependent secretion of wild‐type BDNF in neurosecretory cells and cortical neurons. J Neurosci 24: 4401 – 4411. | en_US |
dc.identifier.citedreference | Cheng C‐Y, Hong C‐J, Yu YW‐Y, Chen T‐J, Wu H‐C, Tsai S‐J ( 2005 ) Brain‐derived neurotrophic factor (Val66Met) genetic polymorphism is associated with substance abuse in males. Brain Res Mol Brain Res 140: 86 – 90. | en_US |
dc.identifier.citedreference | Di Lorenzo C, Di Lorenzo G, Sances G, Ghiotto N, Guaschino E, Grieco GS, Santorelli FM, Casali C, Troisi A, Siracusano A, Pierelli F ( 2008 ) Drug consumption in medication overuse headache is influenced by brain‐derived neurotrophic factor Val66Met polymorphism. J Headache Pain 10: 349 – 355. | en_US |
dc.identifier.citedreference | Ducci F, Goldman D ( 2008 ) Genetic approaches to addiction: genes and alcohol. Addiction 103: 1414 – 1428. | en_US |
dc.identifier.citedreference | Egan MF, Kojima M, Callicott JH, Goldberg TE, Kolachana BS, Bertolino A, Zaitsev E, Gold B, Goldman D, Dean M, Lu B, Weinberger DR ( 2003 ) The BDNF Val66Met polymorphism affects activity‐dependent secretion of BDNF and human memory and hippocampal function. Cell 112: 257 – 269. | en_US |
dc.identifier.citedreference | Enoch MA, Hodgkinson CA, Yuan Q, Albaugh B, Virkkunen M, Goldman D ( 2009 ) GABRA1 and GABRA2 as independent predictors for alcoholism in two populations. Neuropsychopharmacology 34: 1245 – 1254. | en_US |
dc.identifier.citedreference | Everitt BJ, Robbins TW ( 2000 ) Second‐order schedules of drug reinforcement in rats and monkeys: measurement of reinforcing efficacy and drug‐seeking behaviour. Psychopharmacology (Berl) 153: 17 – 30. | en_US |
dc.identifier.citedreference | Frodl T, Schüle C, Schmitt G, Born C, Baghai T, Zill P, Bottlender R, Rupprecht R, Bondy B, Reiser M, Möller HJ, Meisenzahl EM ( 2007 ) Association of the brain‐derived neurotrophic factor Val66Met polymorphism with reduced hippocampal volumes in major depression. Arch Gen Psychiatry 64: 410 – 416. | en_US |
dc.identifier.citedreference | Goggi J, Pullar IA, Carney SL, Bradford HF ( 2002 ) Modulation of neurotransmitter release induced by brain‐derived neurotrophic factor in rat brain striatal slices in vitro. Brain Res 941: 34 – 42. | en_US |
dc.identifier.citedreference | Gottesman II, Gould TD ( 2003 ) The endophenotype concept in psychiatry: etymology and strategic intentions. Am J Psychiatry 160: 636 – 645. | en_US |
dc.identifier.citedreference | Greenwald MK ( 2010 ) Effects of experimental unemployment, employment and punishment analogs on opioid seeking and consumption in heroin‐dependent volunteers. Drug Alcohol Depend 111: 64 – 73. | en_US |
dc.identifier.citedreference | Greenwald MK, Hursh SR ( 2006 ) Behavioral economic analysis of opioid consumption in heroin‐dependent individuals: effects of unit price and pre‐session drug supply. Drug Alcohol Depend 85: 35 – 48. | en_US |
dc.identifier.citedreference | Greenwald MK, Steinmiller CL ( 2009 ) Behavioral economic analysis of opioid consumption in heroin‐dependent individuals: Effects of alternative reinforcer magnitude and post‐session drug supply. Drug Alcohol Depend 104: 84 – 93. | en_US |
dc.identifier.citedreference | Hariri A, Goldberg TE, Mattay VS, Kolachana BS, Callicott JH, Egan MF, Weinberger DR ( 2003 ) Brain‐derived neurotrophic factor Val66Met polymorphism affects human memory‐related hippocampal activity and predicts memory performance. J Neurosci 23: 6690 – 6694. | en_US |
dc.identifier.citedreference | Hatami H, Oryan S, Semnanian S, Kazemi B, Bandepour M, Admadiani A ( 2007 ) Alterations of BDNF and NT‐3 genes expression in the nucleus paragigantocellularis during morphine dependency and withdrawal. Neuropeptides 41: 321 – 328. | en_US |
dc.identifier.citedreference | Hodgkinson CA, Yuan Q, Xu K, Shen P‐H, Heinz E, Lobos EA, Binder EB, Cubells J, Ehlers CL, Gelernter J, Mann J, Riley B, Roy A, Tabakoff B, Todd RD, Zhou Z, Goldman D ( 2008 ) Addictions biology: haplotype‐based analysis for 130 candidate genes on a single array. Alcohol Alcohol 43: 505 – 515. | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.