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Micro RNA expression profile and functional analysis reveal that mi R ‐382 is a critical novel gene of alcohol addiction

dc.contributor.authorLi, Jingyuanen_US
dc.contributor.authorLi, Jingen_US
dc.contributor.authorLiu, Xiaojunen_US
dc.contributor.authorQin, Shanshanen_US
dc.contributor.authorGuan, Yanzhongen_US
dc.contributor.authorLiu, Yuweien_US
dc.contributor.authorCheng, Yunhuien_US
dc.contributor.authorChen, Xiuwenen_US
dc.contributor.authorLi, Wenen_US
dc.contributor.authorWang, Shenmingen_US
dc.contributor.authorXiong, Mingen_US
dc.contributor.authorKuzhikandathil, Eldo V.en_US
dc.contributor.authorYe, Jiang‐hongen_US
dc.contributor.authorZhang, Chunxiangen_US
dc.date.accessioned2013-09-04T17:18:31Z
dc.date.available2014-10-06T19:17:42Zen_US
dc.date.issued2013-09en_US
dc.identifier.citationLi, Jingyuan; Li, Jing; Liu, Xiaojun; Qin, Shanshan; Guan, Yanzhong; Liu, Yuwei; Cheng, Yunhui; Chen, Xiuwen; Li, Wen; Wang, Shenming; Xiong, Ming; Kuzhikandathil, Eldo V.; Ye, Jiang‐hong ; Zhang, Chunxiang (2013). "Micro RNA expression profile and functional analysis reveal that mi R â 382 is a critical novel gene of alcohol addiction." EMBO Molecular Medicine 5(9): 1402-1414. <http://hdl.handle.net/2027.42/99635>en_US
dc.identifier.issn1757-4676en_US
dc.identifier.issn1757-4684en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/99635
dc.description.abstractAlcohol addiction is a major social and health concern. Here, we determined the expression profile of microRNAs (miRNAs) in the nucleus accumbens (NAc) of rats treated with alcohol. The results suggest that multiple miRNAs were aberrantly expressed in rat NAc after alcohol injection. Among them, miR‐382 was down‐regulated in alcohol‐treated rats. In both cultured neuronal cells in vitro and in the NAc in vivo , we identified that the dopamine receptor D1 ( Drd1 ) is a direct target gene of miR‐382. Via this target gene, miR‐382 strongly modulated the expression of DeltaFosB. Moreover, overexpression of miR‐382 significantly attenuated alcohol‐induced up‐regulation of DRD1 and DeltaFosB, decreased voluntary intake of and preference for alcohol and inhibited the DRD1‐induced action potential responses. The results indicated that miRNAs are involved in and may represent novel therapeutic targets for alcoholism. The underlying molecular causes of alcohol addiction remain unclear. Many miRNAs are found modulated in the nucleus accumbens of rats chronically treated with alcohol. Specifically, miR‐382 is shown to regulate alcohol intake via DRD1 and DeltaFosB.en_US
dc.publisherWiley Periodicals, Inc.en_US
dc.subject.otherMicro RNA Sen_US
dc.subject.otherMiR‐382en_US
dc.subject.otherAlcohol Addictionen_US
dc.subject.otherDeltaFosBen_US
dc.subject.otherDopamine Receptor D1en_US
dc.titleMicro RNA expression profile and functional analysis reveal that mi R ‐382 is a critical novel gene of alcohol addictionen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.identifier.pmid23873704en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/99635/1/emmm201201900-sm-0001-Review_Process_File.pdf
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/99635/2/emmm201201900.pdf
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/99635/3/emmm201202100-sm-0006-SourceData-S5.pdf
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/99635/4/emmm201201900-sm-0002-SuppData-S1.pdf
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/99635/5/emmm201202100-sm-0005-SourceData-S4.pdf
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/99635/6/emmm201202100-sm-0004-SourceData-S3.pdf
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/99635/7/emmm201202100-sm-0003-SourceData-S2.pdf
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/99635/8/emmm201202100-sm-0007-SourceData-S6.pdf
dc.identifier.doi10.1002/emmm.201201900en_US
dc.identifier.sourceEMBO Molecular Medicineen_US
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