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Rosette‐like structures in the spectrum of spitzoid tumors

dc.contributor.authorArps, David P.en_US
dc.contributor.authorHarms, Paul W.en_US
dc.contributor.authorChan, May P.en_US
dc.contributor.authorFullen, Douglas R.en_US
dc.date.accessioned2013-09-04T17:18:35Z
dc.date.available2014-10-06T19:17:42Zen_US
dc.date.issued2013-09en_US
dc.identifier.citationArps, David P.; Harms, Paul W.; Chan, May P.; Fullen, Douglas R. (2013). "Rosette‐like structures in the spectrum of spitzoid tumors." Journal of Cutaneous Pathology 40(9): 788-795. <http://hdl.handle.net/2027.42/99651>en_US
dc.identifier.issn0303-6987en_US
dc.identifier.issn1600-0560en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/99651
dc.description.abstractBackground Spitz nevi demonstrate a diverse spectrum of morphologies. Recently, there have been two reported examples of Spitz nevi with rosette‐like structures similar to Homer‐Wright rosettes. Rosettes have also been described in melanomas and in a proliferative nodule arising in a congenital nevus. Methods A retrospective review of 104 cases of Spitz nevi and variants (n = 51), pigmented spindle cell nevi (n = 26), combined melanocytic nevi with features of Spitz (n = 8), atypical Spitz tumor ( AST , n = 9), and spitzoid melanoma (n = 10). Results Rosette‐like structures were present in 3 of the 104 cases (2.9%), including a compound Spitz nevus, a desmoplastic Spitz nevus, and an AST . All three cases demonstrated several foci of small nests of epithelioid cells with peripherally palisaded nuclei arranged around a central area of fibrillar eosinophilic cytoplasm. Immunohistochemical staining of the three spitzoid lesions demonstrated that the rosette‐like structures express S100 protein, Melan‐A, and neuron specific enolase ( NSE ) and lacked expression of neurofilament, glial fibrillary acidic protein and synaptophysin. Conclusions While uncommon, rosette‐like structures can occur as a focal feature in Spitz nevi and AST . Rosette‐like structures may represent a normal morphologic finding in Spitz nevi, and awareness of them may prevent misdiagnosis as a neural tumor or melanoma.en_US
dc.publisherBlackwell Publishing Ltden_US
dc.publisherWiley Periodicals, Inc.en_US
dc.subject.otherRosetteen_US
dc.subject.otherSpitz Nevien_US
dc.subject.otherMelanomaen_US
dc.titleRosette‐like structures in the spectrum of spitzoid tumorsen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelDermatologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.identifier.pmid23808731en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/99651/1/cup12192.pdf
dc.identifier.doi10.1111/cup.12192en_US
dc.identifier.sourceJournal of Cutaneous Pathologyen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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