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Lessons from the RAMPART study—and which is the best route of administration of benzodiazepines in status epilepticus

dc.contributor.authorSilbergleit, Roberten_US
dc.contributor.authorLowenstein, Danielen_US
dc.contributor.authorDurkalski, Valerieen_US
dc.contributor.authorConwit, Robinen_US
dc.date.accessioned2013-09-04T17:18:45Z
dc.date.available2014-10-06T19:17:43Zen_US
dc.date.issued2013-09en_US
dc.identifier.citationSilbergleit, Robert; Lowenstein, Daniel; Durkalski, Valerie; Conwit, Robin (2013). "Lessons from the RAMPART study—and which is the best route of administration of benzodiazepines in status epilepticus." Epilepsia : 74-77. <http://hdl.handle.net/2027.42/99698>en_US
dc.identifier.issn0013-9580en_US
dc.identifier.issn1528-1167en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/99698
dc.publisherWiley Periodicals, Inc.en_US
dc.subject.otherLorazepamen_US
dc.subject.otherEmergency Medical Servicesen_US
dc.subject.otherIntramuscularen_US
dc.subject.otherMidazolamen_US
dc.subject.otherComparative Efficacyen_US
dc.titleLessons from the RAMPART study—and which is the best route of administration of benzodiazepines in status epilepticusen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelMedicine (General)en_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/99698/1/epi12284.pdf
dc.identifier.doi10.1111/epi.12284en_US
dc.identifier.sourceEpilepsiaen_US
dc.identifier.citedreferenceU.S. Government Printing Office via GPO Access. ( 2005 ) Exception from informed consent requirements for emergency research. Code of Federal Regulations, [updated 2005; cited 21CFR50.24]; 291‐2]. Available from: http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=50.24en_US
dc.identifier.citedreferenceWarden CR, Frederick C. ( 2006 ) Midazolam and diazepam for pediatric seizures in the prehospital setting. Prehosp Emerg Care 10: 463 – 467.en_US
dc.identifier.citedreferenceAlldredge BK, Gelb AM, Isaacs SM, Corry MD, Allen F, Ulrich S, Gottwald MD, O'Neil N, Neuhaus JM, Segal MR, Lowenstein DH. ( 2001 ) A comparison of lorazepam, diazepam, and placebo for the treatment of out‐of‐hospital status epilepticus. N Engl J Med 345: 631 – 637.en_US
dc.identifier.citedreferenceDurkalski V, Silbergleit R, Lowenstein D. ( 2011 ) Challenges in the design and analysis of non‐inferiority trials: a case study. Clin Trials 8: 601 – 608.en_US
dc.identifier.citedreferenceMcMullan J, Sasson C, Pancioli A, Silbergleit R. ( 2010 ) Midazolam versus diazepam for the treatment of status epilepticus in children and young adults: a meta‐analysis. Acad Emerg Med 17: 575 – 582.en_US
dc.identifier.citedreferenceMcMullan JT, Pinnawin A, Jones E, Denninghoff K, Siewart N, Spaite DW, Zaleski E, Silbergleit R; Neurological Emergencies Treatment Trials Investigators. ( 2013 ) The 60‐day temperature‐dependent degradation of midazolam and Lorazepam in the prehospital environment. Prehosp Emerg Care 17: 1 – 7.en_US
dc.identifier.citedreferenceSilbergleit R, Durkalski V, Lowenstein D, Conwit R, Pancioli A, Palesch Y, Barsan W; NETT Investigators. ( 2012a ) Intramuscular versus intravenous therapy for prehospital status epilepticus. N Engl J Med 366: 591 – 600.en_US
dc.identifier.citedreferenceSilbergleit R, Biros MH, Harney D, Dickert N, Baren J. ( 2012b ) Implementation of the exception from informed consent regulations in a large multicenter emergency clinical trials network: the RAMPART experience. Acad Emerg Med 19: 448 – 454.en_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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