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Metastatic melanoma of the heart: Retrospective cohort study and systematic review of prevalence, clinical characteristics, and outcomes

dc.contributor.authorBalinski, Alexander M.
dc.contributor.authorVasbinder, Alexi L.
dc.contributor.authorKerndt, Connor C.
dc.contributor.authorCatalan, Tonimarie C.
dc.contributor.authorParry, Nathan P.
dc.contributor.authorRehman, Rafey A.
dc.contributor.authorBlakely, Pennelope
dc.contributor.authorYeow, Raymond Y.
dc.contributor.authorLeja, Monika J.
dc.contributor.authorLao, Christopher D.
dc.contributor.authorFecher, Leslie A.
dc.contributor.authorHayek, Salim S.
dc.date.accessioned2023-03-03T21:10:21Z
dc.date.available2024-03-03 16:10:19en
dc.date.available2023-03-03T21:10:21Z
dc.date.issued2023-02
dc.identifier.citationBalinski, Alexander M.; Vasbinder, Alexi L.; Kerndt, Connor C.; Catalan, Tonimarie C.; Parry, Nathan P.; Rehman, Rafey A.; Blakely, Pennelope; Yeow, Raymond Y.; Leja, Monika J.; Lao, Christopher D.; Fecher, Leslie A.; Hayek, Salim S. (2023). "Metastatic melanoma of the heart: Retrospective cohort study and systematic review of prevalence, clinical characteristics, and outcomes." Cancer Medicine (3): 2356-2367.
dc.identifier.issn2045-7634
dc.identifier.issn2045-7634
dc.identifier.urihttps://hdl.handle.net/2027.42/175926
dc.description.abstractBackgroundCardiac metastasis of melanoma is rare and typically diagnosed post-mortem. Here we perform a retrospective cohort study and systematic review of patients with metastatic melanoma to characterize prevalence, clinical characteristics, and outcomes of cardiac metastasis.MethodsWe reviewed the electronic medical records of all outpatients with metastatic melanoma who underwent evaluation at the University of Michigan in Ann Arbor from January 2009 to January 2022, identifying patients with a clinical or histopathologic diagnosis of cardiac metastasis. We performed a systematic review of the literature to summarize the clinical characteristics and outcomes of patients with melanoma and cardiac metastasis.ResultsOverall, 23 of 1254 (1.8%) patients with metastatic melanoma were diagnosed with cardiac metastasis. Cardiac metastasis was reported in the right ventricle (65%), left ventricle (35%), and right atrium (35%). A total of 11 (48%) patients experienced at least one cardiovascular complication after the diagnosis of cardiac metastasis, the most common being arrhythmia (30%), heart failure (22%), and pericardial effusion (17%). Immunotherapy was more commonly used in patients with cardiac metastasis (80% vs 65%; p = 0.005). Mortality at 2-years post-diagnosis was higher for patients with cardiac metastasis compared to those without (59% vs 37%; p = 0.034). Progression of malignancy was the underlying cause of death of all patients.ConclusionsCardiac metastasis occurs in <2% of patients with metastatic melanoma, can affect all cardiac structures, and is associated with various cardiovascular complications and high mortality.Cardiac metastasis occurs in 2% of patients with metastatic melanoma, can affect all cardiac structures, and is associated with high mortality. Cardiovascular complications may occur after the diagnosis of cardiac metastasis of melanoma, however with limited impact on mortality, which is predominantly due to progression of malignancy.
dc.publisherWiley Periodicals, Inc.
dc.subject.othermelanoma
dc.subject.otherepidemiology
dc.subject.otherprognosis
dc.subject.othermetastasis
dc.titleMetastatic melanoma of the heart: Retrospective cohort study and systematic review of prevalence, clinical characteristics, and outcomes
dc.typeArticle
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelHScience : Science (General)ematology and Oncology
dc.subject.hlbsecondlevelHematology and Oncology
dc.subject.hlbtoplevelHealth Sciences
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/175926/1/cam45058_am.pdf
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/175926/2/cam45058-sup-0001-FigureS1.pdf
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/175926/3/cam45058.pdf
dc.identifier.doi10.1002/cam4.5058
dc.identifier.sourceCancer Medicine
dc.identifier.citedreferenceHaiduk J, Ziemer M. Pregnancy in a patient with metastatic uveal melanoma treated with nivolumab. J Ger Soc Dermatol. 2021; 19 ( 5 ): 762 - 765.
dc.identifier.citedreferenceMousseaux E, Meunier P, Azancott S, Dubayle P, Gaux JC. Cardiac metastatic melanoma investigated by magnetic resonance imaging. Magn Reson Imaging. 1998; 16 ( 1 ): 91 - 95.
dc.identifier.citedreferencePedrotti P, Musca F, Torre M, et al. Cardiac metastatic melanoma: imaging diagnostic clues. J Cardiol Cases. 2015; 12 ( 2 ): 33 - 36.
dc.identifier.citedreferenceKontozis L, Soteriou M, Papamichael D, et al. Isolated right atrial metastasis of malignant melanoma mimicking a myxoma. Hellenic J Cardiol. 2011; 52 ( 3 ): 281 - 284.
dc.identifier.citedreferenceKumar M, Tigadi S, Azrin MA, Kim AS. Multimodality imaging of a right atrial cardiac mass. Cureus. 2019; 11 ( 5 ): e4705.
dc.identifier.citedreferenceRoubille F, Gahide G, Cayla G, et al. Recent malignant dyspnea. Intern Med. 2008; 47 ( 5 ): 427 - 429.
dc.identifier.citedreferenceMindell SM, Chernick AW, Sugarman MH, Zirkin RM, Bloom RE. Right ventricular metastatic melanoma 27 years after resection of the primary tumor. Cancer. 1989; 63 ( 6 ): 1237 - 1239.
dc.identifier.citedreferenceMagnuson WJ, Halligan JB. Successful treatment of melanoma metastatic to the left atrium using external beam radiation therapy. Oncology (Williston Park). 2010; 24 ( 7 ): 650 - 653.
dc.identifier.citedreferenceJudge JM, Tillou JD, Slingluff CL, Kern JA, Kron IL, Weiss GR. Surgical management of the patient with metastatic melanoma to the heart. J Card Surg. 2013; 28 ( 2 ): 124 - 128.
dc.identifier.citedreferenceCicin I, Usta U, Sezer A, et al. Synchronous tonsil, gallbladder, and cardiac metastases without any other visceral metastases of malignant melanoma. Onkologie. 2009; 32 ( 4 ): 197 - 199.
dc.identifier.citedreferenceKhan MA, Pham DC, Guthrie TH. An unusual presentation of metastatic melanoma. Community Oncol. 2011; 8 ( 10 ): 445 - 446.
dc.identifier.citedreferenceSafa H, Glitza Oliva IC. Cardiac metastases in melanoma. N Engl J Med. 2019; 380 ( 9 ): 858.
dc.identifier.citedreferenceMerer DM, Dutcher JP, Mercando A, et al. Case report: clinical findings and successful resection of melanoma metastatic to the right atrium. Cancer Invest. 1994; 12 ( 4 ): 409 - 413.
dc.identifier.citedreferenceEllis CJ, Dennison EM, Simpson IA. Imaging of cardiac metastatic melanoma: trans-oesophageal echocardiography or magnetic resonance imaging? Int J Cardiol. 1993; 41 ( 2 ): 176 - 179.
dc.identifier.citedreferenceBeliaev AM, Ruygrok PN, Stephens R, Haydock DA. Multidisciplinary management of metastatic melanoma to the inter-atrial septum. ANZ J Surg. 2019; 89 ( 3 ): 258 - 260.
dc.identifier.citedreferenceBabar A, Lak H, Chawla S, Mahalwar G, Maroo A. Metastatic melanoma presenting as a ventricular arrhythmia. Cureus. 2020; 12 ( 4 ): e7634.
dc.identifier.citedreferencePoggi R, Pantaleo MA, Benedetti G, Biasco G. Cardiac metastasis of melanoma. Melanoma Res. 2005; 15 ( 4 ): 315 - 316.
dc.identifier.citedreferenceFriedel I, Burchert W, Horstkotte D, Faber L. A rare case of cardiac melanoma mimicking hypertrophic cardiomyopathy. Can J Cardiol. 2017; 33 ( 7 ): 950.e1 - 950.e3.
dc.identifier.citedreferenceFontana A, Corsi D, Viganò E, Trocino G, Achilli F. Added value of real time three-dimensional echocardiography in the diagnosis of an apical right ventricular metastasis from malignant melanoma. Echocardiography. 2013; 30 ( 1 ): E16 - E20.
dc.identifier.citedreferenceDurham CG, Hall JA, Fidone EJ, Mack R, Metting AL. Melanoma to the heart. Proc (Bayl Univ Med Cent). 2016; 29 ( 4 ): 428 - 429.
dc.identifier.citedreferenceBurn PR, Chinn R, King DM. Right atrial metastatic melanoma detected by dynamic contrast enhanced spiral CT. Br J Radiol. 1999; 72 ( 856 ): 395 - 396.
dc.identifier.citedreferenceSteger CM, Mehmeti A, Fischler N. Metastatic melanoma. BMJ Case Rep. 2012; 2012: bcr0220125754.
dc.identifier.citedreferenceLobo A, Lewis JF, Conti CR. Intracardiac masses detected by echocardiography: case presentations and review of the literature. Clin Cardiol. 2000; 23 ( 9 ): 702 - 708.
dc.identifier.citedreferenceGibbs P, Cebon JS, Calafiore P, Robinson WA. Cardiac metastases from malignant melanoma. Cancer. 1999; 85 ( 1 ): 78 - 84.
dc.identifier.citedreferenceMalouf JF, Thompson RC, Maples WJ, Wolfe JT. Diagnosis of right atrial metastatic melanoma by transesophageal echocardiographic-guided transvenous biopsy. Mayo Clin Proc. 1996; 71 ( 12 ): 1167 - 1170.
dc.identifier.citedreferenceBossert T, Van Son JAM, Autschbach R, Mohr FW. Resection of a right atrial metastatic melanoma with unknown origin of primary tumor. Eur J Cardiothorac Surg. 1999; 15 ( 3 ): 373 - 375.
dc.identifier.citedreferenceRoberts WC. Primary and secondary neoplasms of the heart. Am J Cardiol. 1997; 80 ( 5 ): 671 - 682.
dc.identifier.citedreferenceEmmot WW, Vacek JL, Agee K, Moran J, Dunn MI. Metastatic malignant melanoma presenting clinically as obstruction of the right ventricular inflow and outflow tracts. Characterization by magnetic resonance imaging. Chest. 1987; 92 ( 2 ): 362 - 364.
dc.identifier.citedreferenceHoumsse M, Raman SV, Leier CV, Orsinelli DA. Metastatic melanoma of the left ventricle: cardiac imaging in the diagnosis and surgical approach. Int J Cardiovasc Imaging. 2004; 20 ( 6 ): 523 - 526.
dc.identifier.citedreferenceLarkin J, Chiarion-Sileni V, Gonzalez R, et al. Five-year survival with combined nivolumab and ipilimumab in advanced melanoma. N Engl J Med. 2019; 381 ( 16 ): 1535 - 1546.
dc.identifier.citedreferenceRobert C, Grob JJ, Stroyakovskiy D, et al. Five-year outcomes with dabrafenib plus trametinib in metastatic melanoma. N Engl J Med. 2019; 381 ( 7 ): 626 - 636.
dc.identifier.citedreferenceFotouhi Ghiam A, Dawson LA, Abuzeid W, et al. Role of palliative radiotherapy in the management of mural cardiac metastases: who, when and how to treat? A case series of 10 patients. Cancer Med. 2016; 5 ( 6 ): 989 - 996.
dc.identifier.citedreferenceRastrelli M, Tropea S, Rossi CR, Alaibac M. Melanoma: epidemiology, risk factors, pathogenesis, diagnosis and classification. In Vivo (Brooklyn). 2014; 28 ( 6 ): 1005 - 1012.
dc.identifier.citedreferenceSiegel R, Ma J, Zou Z, Jemal A. Cancer statistics, 2014. CA Cancer J Clin. 2014; 64 ( 1 ): 9 - 29.
dc.identifier.citedreferenceJoosse A, de Vries E, Eckel R, et al. Gender differences in melanoma survival: female patients have a decreased risk of metastasis. J Invest Dermatol. 2011; 131 ( 3 ): 719 - 726.
dc.identifier.citedreferencede Vries E, Bray FI, Coebergh JWW, Parkin DM. Changing epidemiology of malignant cutaneous melanoma in Europe 1953-1997. Int J Cancer. 2003; 107: 119 - 126.
dc.identifier.citedreferenceRobinson JK, Mallett KA, Turrisi R, Stapleton J. Engaging patients and their partners in preventive health behaviors the physician factor. Arch Dermatol. 2009; 145 ( 4 ): 469 - 473.
dc.identifier.citedreferenceSwetter SM, Johnson TM, Miller DR, Layton CJ, Brooks KR, Geller AC. Melanoma in middle-aged and older men: a multi-institutional survey study of factors related to tumor thickness. Arch Dermatol. 2009; 145 ( 4 ): 397 - 404.
dc.identifier.citedreferenceJoosse A, Collette S, Suciu S, et al. Superior outcome of women with stage I/II cutaneous melanoma: pooled analysis of four European Organisation for Research and Treatment of Cancer phase III trials. J Clin Oncol. 2012; 30 ( 18 ): 2240 - 2247.
dc.identifier.citedreferenceWolchok JD, Chiarion-Sileni V, Gonzalez R, et al. Long-term outcomes with nivolumab plus ipilimumab or nivolumab alone versus ipilimumab in patients with advanced melanoma. J Clin Oncol. 2022; 40 ( 2 ): 127 - 137.
dc.identifier.citedreferenceRobert C, Karaszewska B, Schachter J, et al. Improved overall survival in melanoma with combined dabrafenib and trametinib. N Engl J Med. 2015; 372 ( 1 ): 30 - 39.
dc.identifier.citedreferenceTas F. Metastatic behavior in melanoma: timing, pattern, survival, and influencing factors. J Oncol. 2012; 2012: 647684.
dc.identifier.citedreferenceBussani R, De-Giorgio F, Abbate A, Silvestri F. Cardiac metastases. J Clin Pathol. 2007; 60 ( 1 ): 27 - 34.
dc.identifier.citedreferenceGlancy DL, Roberts WC. The heart in malignant melanoma. A study of 70 autopsy cases. Am J Cardiol. 1968; 21 ( 4 ): 555 - 571.
dc.identifier.citedreferenceWood A, Markovic SN, Best PJM, Erickson LA. Metastatic malignant melanoma manifesting as an intracardiac mass. Cardiovasc Pathol. 2010; 19 ( 3 ): 153 - 157.
dc.identifier.citedreferenceTyebally S, Chen D, Bhattacharyya S, et al. Cardiac tumors: JACC CardioOncology state-of-the-art review. JACC Cardio Oncol. 2020; 2 ( 2 ): 293 - 311.
dc.identifier.citedreferenceKlatt EC, Heitz DR. Cardiac metastases. Cancer. 1990; 65 ( 6 ): 1456 - 1459.
dc.identifier.citedreferenceMacGee W. Metastatic and invasive tumours involving the heart in a geriatric population: a necropsy study. Virchows Arch A Pathol Anat Histopathol. 1991; 419 ( 3 ): 183 - 189.
dc.identifier.citedreferenceMoher D, Liberati A, Tetzlaff J, Altman DG, PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med. 2009; 6 ( 7 ): e1000097.
dc.identifier.citedreferenceBurns PB, Rohrich RJ, Chung KC. The levels of evidence and their role in evidence-based medicine. Plast Reconstr Surg. 2011; 128 ( 1 ): 305 - 310.
dc.identifier.citedreferenceRosario RT, DiMaio DJ, Lapham RL, Sweeney M, Smalling R, Barasch E. Metastatic ocular melanoma to the left ventricle inducing near-syncope attacks in an 84-year-old woman. Chest. 2000; 118 ( 2 ): 551 - 553.
dc.identifier.citedreferenceKolandjian NA, Patel SP, Papadopoulos NE, Bedikian AY. The left ventricle as the first site of uveal melanoma metastasis 13 years after treatment of the primary tumor. Melanoma Res. 2011; 21 ( 2 ): 160 - 163.
dc.identifier.citedreferenceJakate K, Yanagawa B, Cusimano RJ, Butany J. Uveal melanoma metastasising to the heart after 39 years. J Clin Pathol. 2010; 63 ( 12 ): 1132 - 1133.
dc.identifier.citedreferenceRuiz RS, El-Harazi S, Albert DM, Bryar PJ. Cardiac metastasis of choroidal melanoma. Arch Ophthalmol. 1999; 117 ( 11 ): 1558 - 1559.
dc.identifier.citedreferenceFaustino M, Abecasis J, Freitas A, Gouveia R, Gil V. Symptomatic charcoal heart. Eur Hear J Cardiovasc Imaging. 2014; 15 ( 4 ): 365.
dc.identifier.citedreferenceCatapano-Minotti G, Torracca L, Rizzo N, Corsonello A, Incalzi RA. A case of metastatic melanoma in the heart: does echocardiographic screening matter? Melanoma Res. 2008; 18 ( 3 ): 239 - 240.
dc.identifier.citedreferenceBertella E, Muri M, Negri F, et al. QUICK FIRE CASES-SESSION II 188. AN UNCOMMON METASTATIC MELANOMA. Eur Hear J Cardiovasc Imaging. 2017; 18 ( suppl_2 ): ii122.
dc.identifier.citedreferencePark R, Vincent K, Abdelrahman AA, Krishnan M, Koppala J. An unusual presentation of recurring metastatic melanoma. J Surg Case Rep. 2016; 2016 ( 3 ): rjw030.
dc.identifier.citedreferenceKrüger T, Heuschmid M, Kurth R, Stock UA, Wildhirt SM. Asymptomatic melanoma of the superior cavo-atrial junction: the challenge of imaging. World J Cardiol. 2012; 4 ( 1 ): 20 - 22.
dc.identifier.citedreferenceTas F, Mudun A, Kirma C. Cardiac involvement in melanoma: a case report and review of the literature. J Cancer Res Ther. 2010; 6 ( 3 ): 359 - 361.
dc.working.doiNOen
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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