Synthesis of a [11C]Methoxy derivative of [alpha]-Dihydrotetrabenazine: a radioligand for studying the vesicular monoamine transporter

D Silva, Jean N.; Kilbourn, Michael R.; Mangner, Thomas J.

1993-12

Citation: DaSilva, Jean N., Kilbourn, Michael R., Mangner, Thomas J. (1993/12)."Synthesis of a [11C]Methoxy derivative of [alpha]-Dihydrotetrabenazine: a radioligand for studying the vesicular monoamine transporter." Applied Radiation and Isotopes 44(12): 1487-1489. <http://hdl.handle.net/2027.42/30438>

Abstract: The synthesis of [11C]TBZOMe, a [11C]methoxy derivative at the 2-hydroxy position of [alpha]-dihydrotetrabenazine, was carried out by an O-[11C]methylation reaction. The product [11C]TBZOMe (100-200 mCi) was obtained in 15-40% radiochemical yield (corrected for decay) within 37 min, and in high specific activity (2000-2500 Ci/mmol) and radiochemical purity (>97%). [11C]TBZOMe is a potential new radioligand for studying the vesicular monoamine transporter using positron emission tomography.

DOIs: http://dx.doi.org/10.1016/0969-8043(93)90103-H

PMID: 7903060

URI: http://www.sciencedirect.com/science/article/B6TJ0-46X44N6-69/2/7ad766c2805c203602ac836b38c7d7ab
http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7903060&dopt=citation

Handle: http://hdl.handle.net/2027.42/30438

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