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Synthesis of a [11C]Methoxy derivative of [alpha]-Dihydrotetrabenazine: a radioligand for studying the vesicular monoamine transporter

dc.contributor.authorD Silva, Jean N.en_US
dc.contributor.authorKilbourn, Michael R.en_US
dc.contributor.authorMangner, Thomas J.en_US
dc.date.accessioned2006-04-10T15:30:07Z
dc.date.available2006-04-10T15:30:07Z
dc.date.issued1993-12en_US
dc.identifier.citationDaSilva, Jean N., Kilbourn, Michael R., Mangner, Thomas J. (1993/12)."Synthesis of a [11C]Methoxy derivative of [alpha]-Dihydrotetrabenazine: a radioligand for studying the vesicular monoamine transporter." Applied Radiation and Isotopes 44(12): 1487-1489. <http://hdl.handle.net/2027.42/30438>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6TJ0-46X44N6-69/2/7ad766c2805c203602ac836b38c7d7aben_US
dc.identifier.urihttps://hdl.handle.net/2027.42/30438
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7903060&dopt=citationen_US
dc.description.abstractThe synthesis of [11C]TBZOMe, a [11C]methoxy derivative at the 2-hydroxy position of [alpha]-dihydrotetrabenazine, was carried out by an O-[11C]methylation reaction. The product [11C]TBZOMe (100-200 mCi) was obtained in 15-40% radiochemical yield (corrected for decay) within 37 min, and in high specific activity (2000-2500 Ci/mmol) and radiochemical purity (&gt;97%). [11C]TBZOMe is a potential new radioligand for studying the vesicular monoamine transporter using positron emission tomography.en_US
dc.format.extent254041 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleSynthesis of a [11C]Methoxy derivative of [alpha]-Dihydrotetrabenazine: a radioligand for studying the vesicular monoamine transporteren_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPhysicsen_US
dc.subject.hlbsecondlevelNuclear Engineering and Radiological Sciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelEngineeringen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDivision of Nuclear Medicine, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, MI 48109, U.S.A.en_US
dc.contributor.affiliationumDivision of Nuclear Medicine, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, MI 48109, U.S.A.en_US
dc.contributor.affiliationumDivision of Nuclear Medicine, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, MI 48109, U.S.A.en_US
dc.identifier.pmid7903060en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/30438/1/0000061.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0969-8043(93)90103-Hen_US
dc.identifier.sourceApplied Radiation and Isotopesen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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