Human PCK1 Encoding Phosphoenolpyruvate Carboxykinase Is Located on Chromosome 20q13.2

Yu, Hua; Thun, Rachel; Chandrasekharappa, Settara C.; Trent, Jeffrey M.; Zhang, Ji; Meisler, Miriam H.

1993-01

Citation: Yu, Hua, Thun, Rachel, Chandrasekharappa, Settara, Trent, J. M., Zhang, Ji, Meisler, Miriam H. (1993/01)."Human PCK1 Encoding Phosphoenolpyruvate Carboxykinase Is Located on Chromosome 20q13.2." Genomics 15(1): 219-221. <http://hdl.handle.net/2027.42/31063>

Abstract: Cytoplasmic liver phosphoenolpyruvate carboxykinase (GTP)(PEPCK) catalyzes a rate-limiting step in gluconeogenesis. Primers derived from the rat liver PEPCK sequence were used to amplify a portion of the human liver cDNA and to screen a YAC library of human genomic DNA. The sequences of human and rat PEPCK cDNA differed at 16% of the nucleotides compared (45/291). Analysis of a human/rodent hybrid mapping panel demonstrated concordant segregation of PCK1 with chromosome 20. Fluorescence in situ hybridization with YAC DNA further localized PCK1 to subband 20q13.2.

DOIs: http://dx.doi.org/10.1006/geno.1993.1040

PMID: 8432541

URI: http://www.sciencedirect.com/science/article/B6WG1-45PMRKN-8Y/2/2737c2260927052abb5fe43b7eb7f726
http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8432541&dopt=citation

Handle: http://hdl.handle.net/2027.42/31063

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