Evidence for impaired t cell dna methylation in systemic lupus erythematosus and rheumatoid arthritis
dc.contributor.author | Richardson, Bruce C. | en_US |
dc.contributor.author | Scheinbart, Lee | en_US |
dc.contributor.author | Strahler, John R. | en_US |
dc.contributor.author | Gross, Laura A. | en_US |
dc.contributor.author | Hanash, Samir M. | en_US |
dc.contributor.author | Johnson, Marcia A. | en_US |
dc.date.accessioned | 2006-04-28T16:24:22Z | |
dc.date.available | 2006-04-28T16:24:22Z | |
dc.date.issued | 1990-11 | en_US |
dc.identifier.citation | Richardson, Bruce; Scheinbart, Lee; Strahler, John; Gross, Laura; Hanash, Samir; Johnson, Marcia (1990)."Evidence for impaired t cell dna methylation in systemic lupus erythematosus and rheumatoid arthritis." Arthritis & Rheumatism 33(11): 1665-1673. <http://hdl.handle.net/2027.42/37783> | en_US |
dc.identifier.issn | 0004-3591 | en_US |
dc.identifier.issn | 1529-0131 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/37783 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2242063&dopt=citation | en_US |
dc.description.abstract | Procainamide and hydralazine inhibit T cell DNA methylation and induce autoreactivity in cloned CD4+ T cells. These drugs also induce an autoimmune syndrome, suggesting a possible relationship between DNA hypomethylation, T cell autoreactivity, and certain autoimmune diseases. To test this relationship, DNA methylation was studied in T cells from patients with rheumatoid arthritis and patients with systemic lupus erythematosus, and was found to be impaired. These results support a relationship between DNA hypomethylation and some forms of autoimmune disease. | en_US |
dc.format.extent | 922287 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | John Wiley & Sons, Inc. | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Rheumatology | en_US |
dc.title | Evidence for impaired t cell dna methylation in systemic lupus erythematosus and rheumatoid arthritis | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Geriatrics | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Internal Medicine, University of Michigan, and Veterans Administration Hospital ; Departments of Internal Medicine and Pediatrics, University of Michigan, and the Veterans Administration Hospital, Ann Arbor, Michigan. ; Department of Internal Medicine. University of Michigan. Ann Arbor, MI 48109 | en_US |
dc.contributor.affiliationum | Department of Internal Medicine, University of Michigan ; Departments of Internal Medicine and Pediatrics, University of Michigan, and the Veterans Administration Hospital, Ann Arbor, Michigan. | en_US |
dc.contributor.affiliationum | Department of Pediatrics, University of Michigan ; Departments of Internal Medicine and Pediatrics, University of Michigan, and the Veterans Administration Hospital, Ann Arbor, Michigan. | en_US |
dc.contributor.affiliationum | Department of Internal Medicine, University of Michigan ; Departments of Internal Medicine and Pediatrics, University of Michigan, and the Veterans Administration Hospital, Ann Arbor, Michigan. | en_US |
dc.contributor.affiliationum | Department of Pediatrics, University of Michigan ; Departments of Internal Medicine and Pediatrics, University of Michigan, and the Veterans Administration Hospital, Ann Arbor, Michigan. | en_US |
dc.contributor.affiliationum | Department of Internal Medicine, University of Michigan ; Departments of Internal Medicine and Pediatrics, University of Michigan, and the Veterans Administration Hospital, Ann Arbor, Michigan. | en_US |
dc.identifier.pmid | 2242063 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/37783/1/1780331109_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/art.1780331109 | en_US |
dc.identifier.source | Arthritis & Rheumatism | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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