Now showing items 1-10 of 13
Injectable microparticle-gel system for prolonged and localized lidocaine release. I. In vitro characterization
(Wiley Subscription Services, Inc., A Wiley Company, 2004-09-01)
Current treatment protocol for postoperative pain is to infuse anesthetic solution around nerves or into the epidural space. This clinical practice is beset by the short duration of the anesthetic effect unless the infusion ...
Cluster distance geometry of polypeptide chains
(Wiley Subscription Services, Inc., A Wiley Company, 2004-07-30)
Distance geometry has been a broadly useful tool for dealing with conformational calculations. Customarily each atom is represented as a point, constraints on the distances between some atoms are obtained from experimental ...
Determination of water-soluble acid distribution in poly(lactide- co -glycolide)
(Wiley Subscription Services, Inc., A Wiley Company, 2004-02)
Determination of the kinetics of water-soluble degradation products inside poly(lactide- co -glycolide) (PLGA) delivery systems during polymer degradation is important to evaluate the polymer microclimate conditions, ...
Statistical mechanics of protein folding with separable energy functions
(Wiley Subscription Services, Inc., A Wiley Company, 2004-06-15)
We have initiated an entirely new approach to statistical mechanical models of strongly interacting systems where the configurational parameters and the potential energy function are both constructed so that the canonical ...
Injectable microparticle–gel system for prolonged and localized lidocaine release. II. in vivo anesthetic effects
(Wiley Subscription Services, Inc., A Wiley Company, 2004-09-01)
Current treatment protocols for postoperative pain are beset by either the short duration of the anesthetic effect or requirement of hospitalization of the patients. We reported herein a novel treatment by applying to the ...
The Potential of Raman Spectroscopy as a Process Analytical Technique During Formulations of Topical Gels and Emulsions
(Kluwer Academic Publishers-Plenum Publishers; Springer Science+Business Media, Inc., 2004-10)
Purpose. The primary objective of this study is to investigate the possibility of using Raman spectroscopy as a process analytical technique (PAT) for quality control during manufacturing of topical dosage forms.
Toward Correct Protein Folding Potentials
(Kluwer Academic Publishers; Springer Science+Business Media, 2004-06)
Empirical protein folding potentialfunctions should have a global minimum nearthe native conformationof globular proteins that fold stably, andthey should give the correct free energy offolding. We demonstrate that otherwise ...
Effects of lipid administration on liver apoptotic signals in a mouse model of total parenteral nutrition (TPN)
(Springer-Verlag, 2004-04)
Lipids are an important component of total parenteral nutrition (TPN), contributing the largest caloric load per volume of solution and providing essential fatty acids necessary for survival. However, lipids are known to ...
Statistical mechanics of protein folding by cluster distance geometry
(Wiley Subscription Services, Inc., A Wiley Company, 2004-10-15)
This is our second type of model for protein folding where the configurational parameters and the effective potential energy function are chosen in such a way that all conformations are described and the canonical partition ...
Electrospray sample deposition for matrix-assisted laser desorption/ionization (MALDI) and atmospheric pressure MALDI mass spectrometry with attomole detection limits
(John Wiley & Sons, Ltd., 2004-06-15)
Electrospray sample deposition was explored for matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOFMS). In this method, nanoliter volumes of matrix/analyte mixture were electrosprayed ...