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Cydophosphamide-Induced Abnormalities in the Incisors of the Rat

dc.contributor.authorLee Vahlsing, H.en_US
dc.contributor.authorKim, Sun-Keeen_US
dc.contributor.authorFeringa, Earl R.en_US
dc.date.accessioned2010-04-13T19:29:22Z
dc.date.available2010-04-13T19:29:22Z
dc.date.issued1977en_US
dc.identifier.citationLee Vahlsing, H.; Kim, Sun-Kee; Feringa, Earl (1977). "Cydophosphamide-Induced Abnormalities in the Incisors of the Rat." Journal of Dental Research 7(56): 809-816. <http://hdl.handle.net/2027.42/67458>en_US
dc.identifier.issn0022-0345en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/67458
dc.description.abstractA single injection of 75 mg/kg cyclophosphamide caused gross dental abnormalities in rats. Broken, malformed, overgrown, and "extra" incisors developed several weeks after drug treatment. Radioautographic investigations show no unusual features in the morphology or labeling with H3-thymidine in the odontogenic cells. The results suggest that the cytotoxic effect of the drug is a temporary one which induces a residual alteration of tooth growth.en_US
dc.format.extent3108 bytes
dc.format.extent1075753 bytes
dc.format.mimetypetext/plain
dc.format.mimetypeapplication/pdf
dc.publisherSAGE Publicationsen_US
dc.titleCydophosphamide-Induced Abnormalities in the Incisors of the Raten_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelDentistryen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumVeterans Administration Hospital, Ann Arbor, Michigan48105 USA, Departments of Neurology, Pathology, and Anatomy, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USAen_US
dc.contributor.affiliationumVeterans Administration Hospital, Ann Arbor, Michigan48105 USA, Departments of Neurology, Pathology, and Anatomy, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USAen_US
dc.contributor.affiliationumVeterans Administration Hospital, Ann Arbor, Michigan48105 USA, Departments of Neurology, Pathology, and Anatomy, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USAen_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/67458/2/10.1177_00220345770560071601.pdf
dc.identifier.doi10.1177/00220345770560071601en_US
dc.identifier.citedreferenceLivingston, R.B., and Carter, S.K.: Single Agent in Cancer Chemotherapy, New York, Plenum Publishing Corp., 1970.en_US
dc.identifier.citedreferenceBrookes, P.: Reaction of Alkylating Agents with Nucleic Acids, In Plattner, P.A. (ed.), Proceedings of International Symposium on Chemotherapy of Cancer, Lugano, Amsterdam, Elsevier, pp 32-43, 1964.en_US
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dc.identifier.citedreferencePaterson, P.Y., and Hanson, M.A.: Cyclophosphamide Inhibition of Experimental Allergic Encephalomyelitis and Cellular Transfer of the Disease in Wistar Rats, J Immunol 103:795-806, 1969.en_US
dc.identifier.citedreferenceFeringa, E.R. ; Wendt, J.S.; and Johnson, R.D.: Immunosuppressive Treatment to Enhance Spinal Cord Regeneration in Rats, Neurology (Minneap) 24:287-293, 1975.en_US
dc.identifier.citedreferenceMiller, E.E., and Tsou, K.C.: Comparative Study of Lymphoma-Bearing Rats Treated with DAAP, DMAP, Cytoxan, Proc Am Assoc Cancer Res 7:50, 1966.en_US
dc.identifier.citedreferenceStenram, U., and Nordlinder, H.: Delayed Death in Rats Treated with Cyclophosphamide, Nature 219: 1154, 1968.en_US
dc.identifier.citedreferenceVahlsing, H.L. ; Feringa, E.R. ; Britten, A.G.; and Kinning, W.K.: Dental Abnormalities in Rats After a Single Large Dose of Cyclophosphamide, Cancer Research 35: 2199-2204, 1975.en_US
dc.identifier.citedreferenceSmith, C.E., and Warshawsky, H.: Cellular Renewal in the Enamel Organ and the Odontoblast Layer of the Rat Incisor as Followed by Radioautography Using 3H-Thymidine, Anat Rec 183:523-561, 1975.en_US
dc.identifier.citedreferenceKoppang, H.S. : Histomorphologic Investigations on the Effect of Cyclophosphamide on Dentinogenesis of the Rat Incisor, Scand J Dent Res 81: 383-396, 1973.en_US
dc.identifier.citedreferenceKoppang, H.S. : Autoradiographic Investigations on the Effect of Cyclophosphamide on Dentinogenesis of the Rat Incisor, Scand J Dent Res 81 :397-405, 1973.en_US
dc.identifier.citedreferenceAdatia, A.K. : The Effects of Cyclophosphamide on Odontogenesis in the Rat, Arch Oral Biol 20:141-144, 1975.en_US
dc.identifier.citedreferenceAdatia, A.K. : Burkitt's Tumor in the Jaws, Brit Dent J 120:315-326, 1966.en_US
dc.identifier.citedreferenceAdatia, A.K. : Response of the Dental Elements to Chemotherapy of Burkitt's Tumor, Int Dent J 18:646-653, 1968.en_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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