Autophagy, self-eating at the cellular level, is implicated in many aspects of human physiology and disease. The process involves the formation of a double-membrane vesicle (shown in blue) that sequesters cytosol and organelles (red oblong). Upon completion the resulting autophagosome fuses with the lysosome (green sphere) allowing the cargo to be broken down. The products are recycled to maintain essential cellular processes. See page XXX. [Image: Design by D.J. Klionsky and B.A. Rafferty, 3D Modeling and Rendering by B.A. Rafferty]

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