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- Creator:
- Patil, Crystal
- Description:
- We conducted a hybrid effectiveness-implementation trial at seven clinics in Blantyre District, Malawi, comparing outcomes for 1887 pregnant women randomly assigned to Group ANC or Individual ANC. The seven study clinics were selected in consultation with the Blantyre District health team to represent a diversity of clinics and communities served. The catchment areas and populations served by the clinics differ socioeconomically. Three clinics serve the urban population of Blantyre city, the rapidly-growing second largest city in Malawi. Two clinics serve the peri-urban communities adjacent to metropolitan Blantyre, and two clinics primarily serve a rural and predominately agricultural community. The clinics varied in volume and number of working midwives. , To be eligible to participate in this study, participants had to be pregnant, over the age of 14, have a gestational age of less than 24 weeks, and be capable of making an informed choice about participation. Those aged 15-17 assented with consent from a legal guardian. Those who did not meet all criteria were excluded. All pregnant women presenting for their first antenatal visit received the same standard individual intake visit that included a health assessment with the midwife, laboratory tests, and HIV testing. , and After completing the intake visit, midwives directed clients to study team members so that eligibility could be assessed. Interested women then learned the information needed to give informed consent and sign a consent form. They then completed the baseline self-report survey using Audio Computer-Assisted Self-Interview software. The study statistician determined the randomization order list for each site before recruitment, and assignments were placed in order in sealed envelopes. After completing the baseline survey, the woman selected the next sealed envelope in that clinic’s box to reveal the type of ANC assignment, Group ANC or Individual ANC. Seven individual-level demographic and socioeconomic variables were treated as covariates in all analyses. Two clinic-level variables were also included as covariates, catchment area (rural, peri-urban, or urban) and midwife ANC workloads. Midwife ANC workloads were captured by a ratio of the average number of new ANC clients served each month divided by the number of midwives, with a higher ratio indicating a higher workload. The ratio was highest in two rural-serving clinics and substantially lower in peri-urban and urban communities.
- Keyword:
- Group antenatal care, Malawi, pregnancy, and woman-centered
- Citation to related publication:
- Group antenatal care positively transforms the care experience: Results of an effectiveness trial in Malawi Crystal L. Patil, Kathleen F. Norr, Esnath Kapito, Li C. Liu, Xiaohan Mei, Elizabeth T. Abrams, Elizabeth Chodzaza, Genesis Chorwe-Sungani, Ursula Kafulafula, Allissa Desloge, Ashley Gresh, Rohan D. Jeremiah, Dhruvi R. Patel, Anne Batchelder, Heidy Wang, Jocelyn Faydenko, Sharon S. Rising, Ellen Chirwa medRxiv 2024.12.25.24319635; doi: https://doi.org/10.1101/2024.12.25.24319635
- Discipline:
- Health Sciences
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- Creator:
- Steiner, Allison L., Wozniak, Matthew, Kort, Eric, and DeCola, Phil
- Description:
- Airborne pollen can impact human health by causing seasonal allergies and contribute to the total amount of particulate matter in the atmosphere. Current observations of pollen are limited in both space and time, making it is difficult to accurately forecast how pollen is released into the environment. Lidar is a ground-based remote sensing technique that can identify particles in the atmosphere, and depolarized light can identify irregularly shaped particles like pollen. We deployed a ground-based lidar with depolarization at a forested site in northern Michigan during the spring tree pollination season to understand the timing and contribution of pollen to the total amount of particulate matter in the atmosphere. We identify nine pollen events at the forested site that lead to high particulate matter in the atmosphere. This dataset includes the processed lidar data using the MiniMPL raw event count , which is calibrated and normalized to calculate the normalized relative backscatter (NRB) as a function of height (Ware et al., 2016).
- Keyword:
- lidar; University of Michigan Biological Station; aerosols; depolarization
- Citation to related publication:
- Steiner, A.L., et al. Lidar-based observations of pollen above a mixed hardwood forest in the United States. Submitted.
- Discipline:
- Engineering
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- Creator:
- Hames, Alexandra, Tipirneni, Renuka, Switzer, Galen, Ayanian, John, Kullgren, Jeffrey, Solway, Erica, and Roberts, Eric
- Description:
- We examined whether enrollment in MA was associated with narrower racial and ethnic disparities in cost-related medical care barriers and cost-related dental care barriers as well as receipt of eye exams among near-poor Medicare beneficiaries. We further examined the extent to which racial and ethnic disparities were narrower among MA enrollees than TM enrollees who did and did not have private supplemental insurance. and This deposit includes code to process data for transparency and reproducibility purposes.
- Citation to related publication:
- Hames AG, Tipirneni R, Switzer GE, Ayanian JZ, Kullgren JT, Solway E, Roberts ET. Racial/Ethnic Disparities in Cost-Related Barriers to Care Among Near-Poor Beneficiaries in Medicare Advantage vs Traditional Medicare. Am J Manag Care. 2024;30(10):e297-e304. doi:10.37765/ajmc.2024.89622
- Discipline:
- Health Sciences
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- Creator:
- Aksoy, Doruk and Kim, Donghak
- Description:
- This dataset contains snapshots from simulations of a hexagonal self oscillating gel sheet defined via a triangular lattice. The lattice has stretching springs between neighboring vertices and bending springs with energy proportional to the square of the angle between neighboring traingular faces. The motion of the lattice is driven by time- and space-varying distributions of the rest lengths of the stretching springs. In the motivating experiments on thin gel sheets, there are chemical waves, radial or spiral in form, that induce local swelling of the sheets. As a simple model, this dataset considers radial or planar (unidirectional) traveling waves in the simulations. The sheet is modeled as a flat hexagon of radius 1 with an equilateral triangular triangle lattice mesh, with initially uniform mesh spacing of 1/33, resulting in 3367 mesh points. A small out-of-plane perturbation is applied and the motion evolves over the sheet over time. The sheet is modeled to have damped dynamics. However for large enough wave amplitudes, the sheet rapidly buckles into shapes with time-varying distributions of curvature, large in magnitude. For more information on the simulation that generated the data, please refer to "Semi-implicit methods for the dynamics of elastic sheets,” at Journal of Computational Physics by Alben et al. For an example SciML application that considers this dataset, please refer to "Inverse design of self-oscillatory gels through deep learning." Neural Computing and Applications by Aksoy et al.
- Keyword:
- Soft robotics, Partial Differential Equations, Scientific Simulations, and Chaotic Systems
- Citation to related publication:
- Alben, Silas, et al. "Semi-implicit methods for the dynamics of elastic sheets." Journal of Computational Physics 399 (2019): 108952., Aksoy, Doruk, et al. "Inverse design of self-oscillatory gels through deep learning." Neural Computing and Applications 34.9 (2022): 6879-6905., Aksoy, Doruk, et al. "An incremental tensor train decomposition algorithm." SIAM Journal on Scientific Computing 46.2 (2024): A1047-A1075., and Aksoy, Doruk, and Alex A. Gorodetsky. "Incremental Hierarchical Tucker Decomposition." arXiv preprint arXiv:2412.16544 (2024).
- Discipline:
- Engineering and Science
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- Creator:
- Diaz-Espinosa, Jennifer, Stringer, Kathleen, and Rosania, Gus
- Description:
- These data were produced from a study that assessed mitochondrial metabolic function by measuring two metabolites, l-carnitine and acetylcarnitine, to determine their effectiveness as candidate clinical biomarkers for age-related, drug-induced alterations in mitochondrial metabolism. To study age and medication-related changes in mitochondrial metabolism, we administered the FDA-approved mitochondriotropic drug, clofazimine (CFZ), or vehicle for to young and old mice. These findings are described in our manuscript: Clofazimine-Mediated, Age-Related Changes in Skeletal Muscle Mitochondrial Metabolites. Data reported was supported by funding from the National Institute of General Medical Sciences (NIGMS) at the National Institutes of Health (NIH) under award numbers R01GM127787 (GRR), R35GM136312 (KAS), P30AR069620 (K Jepsen), and T32GM140223 (L Isom).
- Keyword:
- adverse drug reactions, mitochondrial metabolism, l-carnitine, acetylcarnitine, and cardiac muscle
- Citation to related publication:
- Diaz-Espinosa J, Stringer KA, Rosania GR. Clofazimine-Mediated, Age-Related Changes in Skeletal Muscle Mitochondrial Metabolites. Metabolites. 2023 May 19;13(5):671. doi: 10.3390/metabo13050671. PMID: 37233713; PMCID: PMC10220805.
- Discipline:
- Health Sciences
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- Creator:
- Stringer, Kathleen A.
- Description:
- These data were produced from the survival analysis of the pre-treatment metabolomics data generated from the Phase II clinical trial of L-carnitine treatment for septic shock (the RACE trial - see https://clinicaltrials.gov/ct2/show/NCT01665092). The results based on respective acetylcarnitine or valine concentration are presented (pdf). The csv files contain the at risk numbers from the Kaplan-Meier survival analysis. These findings described in our manuscript: Pharmacometabolomics Identifies Candidate Predictor Metabolites of an L-carnitine Treatment Mortality Benefit in Septic Shock. and All of the metabolomics data are available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org which is supported by NIH grant U2C-DK119886 and where it has been assigned Project ID (accession number ST001319). The data can be accessed directly via its Project DOIs: (DOI: http://dx.doi.org/10.21228/M8VX0Z).
- Keyword:
- sepsis, septic shock, survival, mortality, metabolomics, and pharmacometabolomics
- Citation to related publication:
- Puskarich, M. A., Jennaro, T. S., Gillies, C. E., Evans, C. R., Karnovsky, A., McHugh, C. E., Flott, T. L., Jones, A. E., Stringer, K. A., & Investigators, O. behalf of the R. T. (2021). Pharmacometabolomics Identifies Candidate Predictor Metabolites of an L-carnitine Treatment Mortality Benefit in Septic Shock. (Preprint) https://doi.org/10.1101/2021.01.28.21250687 and Puskarich MA, Jennaro TS, Gillies CE, et al; the RACE Trial Investigators. Pharmacometabolomics identifies candidate predictor metabolites of an L-carnitine treatment mortality benefit in septic shock. Clin Transl Sci. 2021; 14: 2288–2299. https://doi.org/10.1111/cts.13088
- Discipline:
- Health Sciences
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- Creator:
- Lester, Corey A, Al Kontar, Raed, and Chen, Qiyuan
- Description:
- The dataset contains images of pills inside a medication bottle from a top down view. The dataset was used to build an image classification model for predicting the national drug code (NDC) of the medication seen in the image. There are 13,955 images of 20 distinct NDC. The image data were used to create a machine learning algorithm which could predict the NDC.
- Keyword:
- Medication, Pills, and Image
- Citation to related publication:
- Lester, C.A., Li, J., Ding, Y. et al. Performance evaluation of a prescription medication image classification model: an observational cohort. npj Digit. Med. 4, 118 (2021). https://doi.org/10.1038/s41746-021-00483-8
- Discipline:
- Health Sciences
-
- Creator:
- Beletsky, Dmitry, Beletsky, R, and Rowe, M
- Description:
- Reliable prediction of hypoxic events in the coastal ocean and lakes depends to a large degree on the ability of hydrodynamic models to accurately simulate nearshore circulation and thermal structure. With focus on the hypoxia-prone south shore of Lake Erie, temperature and currents were measured in the central basin in 2017-2019. Major upwelling events along the south shore were identified and linked with occurrence of strong, sustained wind from the northeast (NE). A three-dimensional FVCOM-based hydrodynamic model was able to predict upwelling events along the south shore reasonably well but the surface mixed layer and thermocline depth were shallower than in observations. It was found that basin-scale wind stress curl (WSC) transformed canonic two-gyre circulation in the uniform NE wind case into a single gyre circulation causing both alongshore and cross-shore current reversal that modified coastal upwelling/downwelling. Observational evidence of Kelvin waves on the south shore was found for the first time. Kelvin wave speed in the model was underestimated. Model runs with enhanced vertical mixing improved predictions of mixed layer and thermocline depth and near-bottom dissolved oxygen but also caused additional diffusion of thermocline.
- Discipline:
- Science
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- Creator:
- Zhu, Yongxian, Deng, Sidi, and Cooper, Daniel R
- Description:
- This dataset is curated as a byproduct of the "Material and Vehicle Design for High-Value Recycling of Aluminum and Steel Automotive Sheet" project, funded by the REMADE Institute of the Department of Energy and referred to as the "Clean Sheet Project" in the file "electricity scenarios slides.pptx." The dataset presents projected U.S. electricity emission factors (MJ primary energy or gCO2/kWh electricity delivered) under various scenarios, including different levels of uptake of the U.S. Inflation Reduction Act. The projections are based on estimated trends in the U.S. electricity generation mix, along with the authors' analysis of the energy and emission intensities of relevant power sources. The dataset supports research—particularly life cycle assessment—relying on U.S. regional energy profile and emissions factors.
- Keyword:
- Electricity Mix, Renewable Energy, Greenhouse Gas Emissions, Decarbonization, and Net-Zero
- Discipline:
- Engineering and General Information Sources
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- Creator:
- Ludlow, Andrew
- Description:
- Single molecule long read RNA/cDNA sequencing of TERT revealed 45 TERT mRNA variants including 13 known and 32 novel variants. Among the variants, TERT Delta 2-4, which lacks exons 2-4 but retains the original open reading frame, was selected for further study. Induced pluripotent stem cells and cancer cells express higher levels of TERT Delta 2-4 compared to primary human bronchial epithelial cells. Overexpression of TERT Delta 2-4 enhanced clonogenicity and resistance to cisplatin-induced apoptosis. Knockdown of endogenous TERT Delta 2-4 in Calu-6 cells reduced clonogenicity and resistance to cisplatin. Our results suggest that TERT Delta 2-4 enhances cancer cells’ resistance to intrinsic apoptosis. RNA sequencing following knockdown of Delta 2-4 TERT indicates that translation is downregulated and that mitochondrial related proteins are upregulated compared to controls.
- Keyword:
- TERT, Alternative splicing, Telomere, and Telomerase
- Citation to related publication:
- Kim, J.J., Ahn, A., Ying, J.Y. et al. Discovery and characterization of a novel telomerase alternative splicing isoform that protects lung cancer cells from chemotherapy induced cell death. Sci Rep 15, 6787 (2025). https://doi.org/10.1038/s41598-025-90639-3
- Discipline:
- Science