In a sensitive cochlea, the basilar membrane response to transient excitation of any kind--normal acoustic or artificial intracochlear excitation--consists of not only a primary impulse but also a coda of delayed secondary responses with varying amplitudes but similar spectral content around the characteristic frequency of the measurement location. The coda, sometimes referred to as echoes or ringing, has been described as a form of local, short term memory which may influence the ability of the auditory system to detect gaps in an acoustic stimulus such as speech. Depending on the individual cochlea, the temporal gap between the primary impulse and the following coda ranges from once to thrice the group delay of the primary impulse (the group delay of the primary impulse is on the order of a few hundred microseconds). The coda is physiologically vulnerable, disappearing when the cochlea is compromised even slightly. The multicomponent sensitive response is not yet completely understood. We use a physiologically-based, mathematical model to investigate (i) the generation of the primary impulse response and the dependence of the group delay on the various stimulation methods, (ii) the effect of spatial perturbations in the properties of mechanically sensitive ion channels on the generation and separation of delayed secondary responses. The model suggests that the presence of the secondary responses depends on the wavenumber content of a perturbation and the activity level of the cochlea. In addition, the model shows that the varying temporal gaps between adjacent coda seen in experiments depend on the individual profiles of perturbations. Implications for non-invasive cochlear diagnosis are also discussed.
Citation to related publication:
Li, Yizeng, and Karl Grosh. “The Coda of the Transient Response in a Sensitive Cochlea: A Computational Modeling Study.” PLOS Computational Biology 12, no. 7 (July 5, 2016): e1005015. https://doi.org/10.1371/journal.pcbi.1005015
All animal-related procedures were approved by the University of Michigan Institutional Animal Care and Use Committee (Protocols #PRO00006234 and #PRO00008306) and the Peruvian government SERFOR (Servicio Nacional Forestal y de Fauna Silvestre. and Data were collected during five field expeditions in the Amazonian lowlands of Peru from March 2016 to December 2018.
This data set includes four zipped files each containing unprocessed cell images from a single cell line collected as raw data, the scripts used to process these images and tabular files with the processed data outputs. This data set supports the PLOS ONE publication, "Cell-morphodynamic phenotype classification with application to cancer metastasis using cell magnetorotation and machine-learning."
The files include all the published paper and presentation source codes. Please install Matpower before running the code. The Matpower version is 5.1, which can be found in https://matpower.org/download/
Talks, papers, and poster in Deep Blue: http://hdl.handle.net/2027.42/150104
Yao, M., Molzahn, D. K., & Mathieu, J. L. (2019). An Optimal Power-Flow Approach to Improve Power System Voltage Stability Using Demand Response. IEEE Transactions on Control of Network Systems, 6(3), 1015–1025. https://doi.org/10.1109/TCNS.2019.2910455, Yao, M., Mathieu, J. L., & Molzahn, D. K. (2017). Using demand response to improve power system voltage stability margins. 2017 IEEE Manchester PowerTech, 1–6. https://doi.org/10.1109/PTC.2017.7980798 , Koorehdavoudi, K., Yao, M., & Mathieu, J. (2017). Using Demand Response to Shape the Fast Dynamics of the Bulk Power Network. https://www.semanticscholar.org/paper/Using-Demand-Response-to-Shape-the-Fast-Dynamics-of-Koorehdavoudi-Yao/6799c161744c29e7603e3601daa284ecc84788a8, Yao, M., Hiskens, I. A., & Mathieu, J. L. (2018). Improving Power System Voltage Stability by Using Demand Response to Maximize the Distance to the Closest Saddle-Node Bifurcation. 2018 IEEE Conference on Decision and Control (CDC), 2390–2395. https://doi.org/10.1109/CDC.2018.8619091 , and Yao, M., Molzahn, D. K., & Mathieu, J. L. (2017). The impact of load models in an algorithm for improving voltage stability via demand response. 2017 55th Annual Allerton Conference on Communication, Control, and Computing (Allerton), 149–156. https://doi.org/10.1109/ALLERTON.2017.8262731
SWMF is used to study the segmentation of SED plume into polar cap patches during the geomagnetic storm on Sep 7, 2017. The database includes the 3D output in the upper atmosphere from GITM, the 2D output from Ionospheric Electrodynamics (IE) and 3D output from BATSRUS. The output from GITM can be read with thermo_batch_new.pro. The output from IE can be opened with Spacepy at https://pythonhosted.org/SpacePy/. The output from BATSRUS can be opened with tecplot.
More details can be found in Readme.txt.
Wang, Z., Zou, S., Coppeans, T., Ren, J., Ridley, A., & Gombosi, T. (2019). Segmentation of SED by Boundary Flows Associated With Westward Drifting Partial Ring current. Geophysical Research Letters, 46(14), 7920–7928. https://doi.org/10.1029/2019GL084041
This is data is a large assortment of over 50 1,4-polybutadiene star-linear blends that can be used for assessing and developing predictive models. The data are presented in CSV files.
Hall, R., Desai, P. S., Kang, B.-G., Huang, Q., Lee, S., Chang, T., Venerus, D. C., Mays, J., Ntetsikas, K., Polymeropoulos, G., Hadjichristidis, N., & Larson, R. G. (2019). Assessing the Range of Validity of Current Tube Models through Analysis of a Comprehensive Set of Star–Linear 1,4-Polybutadiene Polymer Blends. Macromolecules, 52(20), 7831–7846. https://doi.org/10.1021/acs.macromol.9b00642
We used data collected from participants of the Early Life Exposures in Mexico to ENvironmental Toxicants (ELEMENT) study, which consists of three sequentially-enrolled birth cohorts of pregnant women. Research protocols of this study were approved by the Institutional Review Board at University of Michigan and the Mexico National Institute of Public Health. We obtained informed consent from mothers and informed assent from children prior to enrollment.
Citation to related publication:
Liu, Y., Ettinger, A. S., Téllez-Rojo, M., Sánchez, B. N., Zhang, Z., Cantoral, A., Hu, H., & Peterson, K. E. (2020). Prenatal Lead Exposure, Type 2 Diabetes, and Cardiometabolic Risk Factors in Mexican Children at Age 10–18 Years. The Journal of Clinical Endocrinology & Metabolism, 105(1), 210–218. https://doi.org/10.1210/clinem/dgz038
Crouzon FGFR2-C342Y/+ and wild type littermate pups on a BALB/c congenic background were injected with lentivirus expressing TNAP enzyme or phosphate buffered saline shortly after birth. Mice were euthanized 4 weeks after birth for analyses.
Nam, H. K., Vesela, I., Schutte, S. D., & Hatch, N. E. (2020). Viral delivery of tissue nonspecific alkaline phosphatase diminishes craniosynostosis in one of two FGFR2C342Y/+ mouse models of Crouzon syndrome. PLOS ONE, 15(5), e0234073. https://doi.org/10.1371/journal.pone.0234073
