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- Creator:
- Hatch, Nan E.
- Description:
- Craniosynostosis is the premature fusion of cranial bones. The goal of this study was to determine if delivery of recombinant tissue nonspecific alkaline phosphatase (TNAP) could prevent or diminish the severity of craniosynostosis in a C57BL/6 FGFR2C342Y/+ model of neonatal onset craniosynostosis or a BALB/c FGFR2C342Y/+ model of postnatal onset craniosynostosis. Mice were injected with a lentivirus encoding a mineral targeted form of TNAP immediately after birth. Cranial bone fusion as well as cranial bone volume, mineral content and density were assessed by micro computed tomography. Craniofacial shape was measured with calipers., Alkaline phosphatase, alanine amino transferase (ALT) and aspartate amino transferase (AST) activity levels were measured in serum. Neonatal delivery of TNAP diminished craniosynostosis severity from 94% suture obliteration in vehicle treated mice to 67% suture obliteration in treated mice, p<0.02) and the incidence of malocclusion from 82.4% to 34.7% (p<0.03), with no effect on cranial bone in C57BL/6 FGFR2C342Y/+ mice. In contrast, treatment with TNAP improved cranial bone volume (p< 0.01), density (p< 0.01) and mineral content (p< 0.01) but had no effect on craniosynostosis or malocclusion in BALB/c FGFR2C342Y/+ mice. , These results indicate that post-natal recombinant TNAP enzyme therapy diminishes craniosynostosis severity in the C57BL/6 FGFR2C342Y/+ neonatal onset mouse model of Crouzon syndrome, and that effects of exogenous TNAP are genetic background dependent., and Included in this collection is one set of images representing the C57BL/6 FGFR2C342Y/+ model of neonatal onset craniosynostosis, and one for the BALB/c FGFR2C342Y/+ model of postnatal onset craniosynostosis
- Keyword:
- craniofacial, bone, craniosynostosis, FGFR2, TNAP, mouse model, and development
- Discipline:
- Health Sciences
2Works -
Site Data
User Collection
- Creator:
- Galaty, Michael
- Description:
- This sub-collection includes Photographs and Photologs of the sites, a Site Database with information collected and observed about the site and Site documentation. Documentation consists of PDFs of scans of miscellaneous documents related to a particular site, including maps, wall drawings, original notes, etc. Data are organized according to site number: S001, S002, etc. There are 17 sites in total.
- Keyword:
- archaeology
- Discipline:
- Science
3Works -
Gajtan
User Collection
- Creator:
- Galaty, Michael
- Description:
- The following works contain the databases, field notebooks, unit and profile drawings, photographs, photo descriptions, radiocarbon dates, and geophysical survey data related to the Gajtan settlement excavation.
- Keyword:
- archaeology
- Discipline:
- Science and Humanities
5Works -
Radionuclide PET/CT, SPECT/CT, and Contours Collection
User Collection
- Creator:
- Van, Benjamin and Dewaraja, Yuni
- Description:
- Interest in quantitative imaging of Y-90 and Lu-177 is growing due to their increased use as minimally invasive treatments for primary and metastatic tumors such as HCC and NETs. Accurate quantification of the 3D activity distribution for voxel-level dosimetry requires SPECT/CT and PET/CT imaging. This collection provides research access to anonymized PET/CT and SPECT/CT scans along with the relevant lesion/organ contours taken from University of Michigan clinical research studies of selected patients undergoing radionuclide treatments. All patients signed an informed consent to participate in the research studies. See the readme in each dataset for information on use and citation of this data.
- Discipline:
- Health Sciences
1Works -
- Creator:
- Towne, Aaron
- Description:
- This database contains six datasets intended to aid in the conception, training, demonstration, evaluation, and comparison of reduced-complexity models for fluid mechanics. The six datasets are: large-eddy-simulation data for a turbulent jet, direct-numerical-simulation data for a zero-pressure-gradient turbulent boundary layer, particle-image-velocimetry data for the same boundary layer, direct-numerical-simulation data for laminar stationary and pitching flat-plate airfoils, particle-image-velocimetry and force data for an airfoil encountering a gust, and large-eddy-simulation data for the separated, turbulent flow over an airfoil. All data are stored within hdf5 files, and each dataset additionally contains a README file and a Matlab script showing how the data can be read and manipulated. Since all datafiles use the hdf5 format, they can alternatively be read within virtually any other programing environment. An example.zip file included for each dataset provides an entry point for users. The database is an initiative of the AIAA Discussion Group on Reduced-Complexity Modeling and is detailed in the paper listed below. For each dataset, the paper introduces the flow setup and computational or experimental methods, describes the available data, and provide an example of how these data can be used for reduced-complexity modeling. All users should cite this paper as well as appropriate primary sources contained therein. Towne, A., Dawson, S., Brès, G. A., Lozano-Durán, A., Saxton-Fox, T., Parthasarthy, A., Biler, H., Jones, A. R., Yeh, C.-A., Patel, H., Taira, K. (2022). A database for reduced-complexity modeling of fluid flows. AIAA Journal 61(7): 2867-2892.
- Keyword:
- fluid dynamics, reduced-complexity models, and data-driven models
- Discipline:
- Engineering and Science
6Works -
Division of Reptiles and Amphibians
User Collection
- Creator:
- University of Michigan Museum of Zoology
- Description:
- The Division of Reptiles and Amphibians maintains a collection that is worldwide in scope. The research collections contain over 200,000 catalogued lots representing approximately 435,000 individual specimens.
- Discipline:
- Science
13Works -
- Creator:
- Ali, Hashim, Subramani, Surya , Sudhir, Shefali , Varahamurthy, Raksha , and Malik, Hafiz
- Description:
- Voice-cloning (VC) systems have seen an exceptional increase in the realism of synthesized speech in recent years. The high quality of synthesized speech and the availability of low-cost VC services have given rise to many potential abuses of this technology such as online smearing campaigns and dissemination of fabricated information etc. A number of detection methodologies have been proposed over the years that can detect voice spoofs with reasonably good accuracy. However, these methodologies are mostly evaluated on clean audio databases, such as Asvspoof 2019. This research aims to evaluate state-of-the-art (SOTA) Audio Spoof Detection approaches in the presence of laundering attacks. In that regard, a new laundering attack database, called ASVspoof Laundering Database, is created. This database is based on the ASVspoof 2019 LA eval database comprising a total of 1388.22 hours of audio recordings. Seven SOTA audio spoof detection approaches are evaluated on this laundered database. The results indicate that SOTA systems perform poorly in the presence of aggressive laundering attacks, especially reverberation and additive noise attacks. This suggests the need for robust audio spoof detection.
- Keyword:
- Audio Forensics, Audio Antispoofing, Audio Deepfakes, ASVSpoof, and Machine Learning
- Discipline:
- Engineering
-
- Creator:
- Asthana, Vishwaratn, Monovoukas, Demetri, Kucharski, Kevin, Chopra, Zoey, Perkins, Sidney, and Bugga, Pallavi
- Description:
- It is difficult to model outcomes in patients post-ST Elevation Myocardial Infarction (STEMI), particularly onset of heart failure. The acute insult following a myocardial infarction and chronic degeneration seen in HF involve a similar process where a loss of cardiomyocytes and abnormal remodeling lead to pump failure. This process may alter the strength and direction of the heart’s net depolarization signal. The investigators hypothesized that changes over time in unique parameters extracted using vectorcardiography (VCG) have the potential to predict clinical outcomes in patients post-STEMI and could eventually be used as a non-invasive and cost-effective surveillance tool for characterizing the severity and progression of HF to guide evidence-based therapies.
- Keyword:
- Cardiology, ECG, VCG, STEMI, and Heart Failure
- Discipline:
- Health Sciences
-
- Creator:
- Fu, Xun, Zhang, Bohao, Weber, Ceri J., Cooper, Kimberly L., Vasudevan, Ram, and Moore, Talia Y.
- Description:
- Tails used as inertial appendages induce body rotations of animals and robots---a phenomenon that is governed largely by the ratio of the body and tail moments of inertia. However, vertebrate tails have more degrees of freedom (e.g., number of joints, rotational axes) than most current theoretical models and robotic tails. To understand how morphology affects inertial appendage function, we developed an optimization-based approach that finds the maximally effective tail trajectory and measures error from a target trajectory. For tails of equal total length and mass, increasing the number of equal-length joints increased the complexity of maximally effective tail motions. When we optimized the relative lengths of tail bones while keeping the total tail length, mass, and number of joints the same, this optimization-based approach found that the lengths match the pattern found in the tail bones of mammals specialized for inertial maneuvering. In both experiments, adding joints enhanced the performance of the inertial appendage, but with diminishing returns, largely due to the total control effort constraint. This optimization-based simulation can compare the maximum performance of diverse inertial appendages that dynamically vary in moment of inertia in 3D space, predict inertial capabilities from skeletal data, and inform the design of robotic inertial appendages.
- Keyword:
- simulation, inertial maneuvering, caudal vertebrae, trajectory optimization, and reconfigurable appendages
- Citation to related publication:
- Xun Fu, Bohao Zhang, Ceri J. Weber, Kimberly L. Cooper, Ram Vasudevan, Talia Y. Moore. (in review) Jointed tails enhance control of three-dimensional body rotation.
- Discipline:
- Engineering and Science
-
- Creator:
- Gottesman, Ari
- Description:
- This study analyzes correlations between magnetic field data from closely-spaced pairs of ground magnetometers to observe the spatial scale of ionospheric current signatures. Correlations were mainly calculated in 7.5 minute intervals for periods of multiple days. Distributions were taken from the collection of these 7.5 minute intervals to identify the amount of time where the magnetometers were observing "similar" or "different" ionospheric signatures. The raw magnetometer data was taken from two geomagnetic storms: one taking place on 7-8 September, 2017, and the other taking place on 23-24 March, 2023. These periods were selected due to the presence of both high and low geomagnetic activity. The final distributions calculated from this analysis are available in Correlation_Distributions.csv.
- Keyword:
- Space Weather Impacts, Geomagnetically Induced Currents, and GIC
- Discipline:
- Science