Kansas City, MO emissions can affect a severe weather system by altering the number of CCN, which drives changes in the hydrometeor development. The hydrometeor changes affect cold pool strength, size, and propagation which ultimately determine the strength of the squall line that crosses Kansas City, MO.
Kawecki, S., G.M. Henebry, and A.L. Steiner, 2016: Effects of Urban Plume Aerosols on a Mesoscale Convective System. J. Atmos. Sci., 73, 4641–4660, https://doi.org/10.1175/JAS-D-16-0084.1
Ruas, T. L., & Grosky, W. I. (2017). Exploring and expanding the use of lexical chains in information retrieval. Ann Arbor: University of Michigan. Retrieved from the Deep Blue institutional repository website: http://dx.doi.org/10.3998/2027.42/136659
These manikins represent body shape models for children weighing 9 to 23 kg in a seated posture relevant to child restraint design. The design of child restraints is guided in part by anthropometric data describing the distributions of body dimensions of children. However, three-dimensional body shape data have not been available for children younger than three years of age. These manikins will be useful for assessing child accommodation in restraints. The SBSM can also provide guidance for the development of anthropomorphic test devices and computational models of child occupants.
The sampled manikins were predicted for a range of torso length and body weight dimensions. The SBSM model was exercised for two torso lengths and nine body weights to obtain 18 body shapes. The 3D shape models can be downloaded in a standard mesh format (PLY). Each body shape is accompanied by predicted landmark locations and standard anthropometric variables.
http://childshape.org/toddler/manikins/ and Jones, M.L.H., Klinich, K.D., Ebert, S.M., Malik, L., Manary, M.A., and Reed, M.P. (2015). A Pilot Study of Toddler Anthropometry and Posture in Child Restraint Systems. Short Communications from AAAM's 59th Annual Scientific Conference, Traffic Injury Prevention, 16:sup2, S240-S243, DOI: 10.1080/15389588.2015.1073071 https://doi.org/10.1080/15389588.2015.1073071
This study evaluated the performance of a video-based intervention for improving the belt fit obtained by drivers. Previous laboratory studies have demonstrated that some drivers position their seat belts suboptimally. Specifically, the lap portion of the belt may be higher and farther forward relative to the pelvis than best practice, and the shoulder portion of the belt may be outboard or inboard of mid-shoulder.
A video was developed to present the most important aspects of belt fit best practices, with emphasis on the lap belt. The video demonstrated how a seat belt should be routed with respect to an individual’s anatomy to ensure a proper fit. The three key belt fit concepts conveyed in the video were:
1) Lap belt low on hips, touching the thighs.
2) Shoulder belt crossing middle of collarbone.
3) Belt snug, as close to bones as possible.
Additional context about the ability to achieve to good belt fit, such as opening a heavy coat or adjusting the height adjusters on the B-pillar behind the windows, were also presented.
Jones, M.L.H., Ebert, S.M., Buckley, L., Park, J., and Reed, M.P. (2016). Evaluating an Intervention to Improve Belt Fit for Drivers. Technical Report UMTRI 2016-12. University of Michigan Transportation Research Institute, Ann Arbor, MI. , Reed, M.P., Ebert-Hamilton, S.M. and Rupp, J.D. (2012). Effects of obesity on seat belt fit. Traffic Injury Prevention, 13(4):364-372. https://doi.org/10.1080/15389588.2012.659363, Reed, M.P., Ebert, S.M. and Hallman, J.J. (2013). Effects of driver characteristics on seat belt fit. Stapp Car Crash Journal, 57:43-57. https://pubmed.ncbi.nlm.nih.gov/24435726/, and Jones, M.L.H., Ebert, S.M., and Reed, M.P. (2015). Effects of High Levels of Obesity on Driver Seat Belt Fit. Advancing Transportation Leadership and Safety Technical Report ATLAS-2015-016. University of Michigan Transportation Research Institute, Ann Arbor, MI. https://trid.trb.org/view/1427384 http://www.atlas-center.org/wp-content/uploads/2015/08/ATLAS-Final-Report-ATLAS-2016-15.pdf
The information and education environment refers to: 1) the presence of information infrastructures such as broadband Internet access and public libraries in a location; 2) a person’s proximity to information infrastructures and sources; 3) the distribution of information infrastructures, sources and in a specific location; and 4) exposure to specific messages (information content) within a specific location.
Coverage for all data: 10-county Detroit-Warren-Ann Arbor Combined Statistical Area.
We provide the parameters used in Umbrella Sampling simulations reported in our study "Efficient Estimation of Binding Free Energies between Peptides and an MHC Class II Molecule Using Coarse-Grained Molecular Dynamics Simulations with a Weighted Histogram Analysis Method", namely the set positions and spring constants for each window in simulations. Two tables are provided. Table 1 lists the names of the peptides and their corresponding sequences. Table 2 lists the parameters. The abstract of our work is the following:
We estimate the binding free energy between peptides and an MHC class II molecule using molecular dynamics (MD) simulations with Weighted Histogram Analysis Method (WHAM). We show that, owing to its more thorough sampling in the available computational time, the binding free energy obtained by pulling the whole peptide using a coarse-grained (CG) force field (MARTINI) is less prone to significant error induced by biased-sampling than using an atomistic force field (AMBER). We further demonstrate that using CG MD to pull 3-4 residue peptide segments while leaving the remain-ing peptide segments in the binding groove and adding up the binding free energies of all peptide segments gives robust binding free energy estimations, which are in good agreement with the experimentally measured binding affinities for the peptide sequences studied. Our approach thus provides a promising and computationally efficient way to rapidly and relia-bly estimate the binding free energy between an arbitrary peptide and an MHC class II molecule.
The rapid activation of the mechanistic target of rapamycin complex-1 (mTORC1) by growth factors is increased by extracellular amino acids through yet-undefined mechanisms of amino acid transfer into endolysosomes. Because the endocytic process of macropinocytosis concentrates extracellular solutes into endolysosomes and is increased in cells stimulated by growth factors or tumor-promoting phorbol esters, we analyzed its role in amino acid–dependent activation of mTORC1. Here, we show that growth factor-dependent activation of mTORC1 by amino acids, but not glucose, requires macropinocytosis. In murine bone marrow–derived macrophages and murine embryonic fibroblasts stimulated with their cognate growth factors or with phorbol myristate acetate, activation of mTORC1 required an Akt-independent vesicular pathway of amino acid delivery into endolysosomes, mediated by the actin cytoskeleton. Macropinocytosis delivered small, fluorescent fluid-phase solutes into endolysosomes sufficiently fast to explain growth factor–mediated signaling by amino acids. Therefore, the amino acid–laden macropinosome is an essential and discrete unit of growth factor receptor signaling to mTORC1
Sei Yoshida, Regina Pacitto, Yao Yao, Ken Inoki, Joel A. Swanson; Growth factor signaling to mTORC1 by amino acid–laden macropinosomes. J Cell Biol 12 October 2015; 211 (1): 159–172. https://doi.org/10.1083/jcb.201504097
The food environment is: 1) The physical presence of food that affects a person’s diet; 2) A person’s proximity to food store locations; 3) The distribution of food stores, food service, and any physical entity by which food may be obtained; or 4) A connected system that allows access to food. (Source: https://www.cdc.gov/healthyplaces/healthtopics/healthyfood/general.htm) Data included here concern: 1) Food access; and 2) Liquor access. Spatial Coverage for most data: 10-county Detroit-Warren-Ann Arbor Combined Statistical Area, Michigan, USA. See exception for grocery store data below.
