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- Creator:
- Song, Siliang and Zhang, Jianzhi
- Description:
- Fitness landscapes map genotypes to their corresponding fitness under given environments and allow explaining and predicting evolutionary trajectories. Of particular interest is the landscape ruggedness or the unevenness of the landscape, because it impacts many aspects of evolution such as the likelihood that a population is trapped in a local fitness peak. Although the ruggedness has been inferred from a number of empirically mapped fitness landscapes, it is unclear to what extent this inference is affected by fitness estimation error, which is inevitable in the experimental determination of fitness landscapes. Here we address this question by simulating fitness landscapes under various theoretical models, with or without fitness estimation error. We find that all eight examined measures of landscape ruggedness are overestimated due to imprecise fitness quantification, but different measures are affected to different degrees. We devise a method to use replicate fitness measures to correct this bias and show that our method performs well under realistic conditions. We conclude that previously reported fitness landscape ruggedness is likely upward biased owing to the negligence of fitness estimation error and advise that future fitness landscape mapping should include at least three biological replicates to permit an unbiased inference of the ruggedness.
- Keyword:
- adaptation, estimation error, evolution, NK model, Rough Mount Fuji model, and polynomial model
- Discipline:
- Science
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- Creator:
- Engel, Daniel D. , Evans, Mary Anne, Low, Bobbi S., and Schaeffer, Jeff
- Description:
- This dataset was compiled as an attempt to understand how natural resource managers and research ecologists in the Great Lakes region integrate the ecosystem services (ES) paradigm into their work. The following text is the adapted abstract from a thesis associated with this data. Ecosystem services, or the benefits people obtain from ecosystems, have gained much momentum in natural resource management in recent decades as a relatively comprehensive approach to provide quantitative tools for improving decision-making and policy design. However, to date we know little about whether and how natural resource practitioners, from natural resource managers to research ecologists (hereafter managers and ecologists respectively), have adopted the ES paradigm into their respective work. Here, we addressed this knowledge gap by asking managers and ecologists about whether and how they have adopted the ES paradigm into their respective work. First, we surveyed federal, state, provincial and tribal managers in the Great Lakes region about their perception and use of ES as well as the relevance of specific services to their work. Although results indicate that fewer than 31% of the managers said they currently consider economic values of ES, 79% of managers said they would use economic information on ES if they had access to it. Additionally, managers reported that ES-related information was generally inadequate for their resource management needs. We also assessed managers by dividing them into identifiable groups (e.g. managers working in different types of government agencies or administrative levels) to evaluate differential ES integration. Overall, results suggest a desire among managers to transition from considering ES concepts in their management practices to quantifying economic metrics, indicating a need for practical and accessible valuation techniques. Due to a sample of opportunity at the USGS Great Lakes Science Center (GLSC), we also evaluated GLSC research ecologists’ integration of the ES paradigm because they play an important role by contributing requisite ecological knowledge for ES models. Managers and ecologists almost unanimously agreed that it was appropriate to consider ES in resource management and also showed convergence on the high priority ES. However, ecologists appeared to overestimate the adequacy of ES-related information they provide as managers reported the information was inadequate for their needs. This divergence may reflect an underrepresentation of ecological economists in this system who can aid in translating ecological models into estimates of human well-being. As a note, the dataset for the research ecologists has had some data removed as it could be considered personally identifiable information due to the small sample size in that population. The surveys associated with both datasets have also been included in PDF format. Curation Notes: Three files were added to the data set on Dec 21, 2017. Two csv files: "Ecosystem services and Research Ecologists - Data Index.csv" and "Ecosystem services and Research Managers - Data Index.csv" and one text file: "Ecosystem Services Adoption Readme.txt". The file names of the original four files were altered to replace an ampersand with the word "and".
- Keyword:
- Research Ecologist, Decision-Making, Ecosystem Services, Natural Resource Management, Paradigm Adoption, and Ecological Economics
- Citation to related publication:
- Engel, D.D., Evans, M.A., Low, B.S., Schaeffer, J. (2017) “Understanding Ecosystem Services Adoption by Natural Resource Managers and Research Ecologists.” Journal of Great Lakes Research, 43(3), 169-179. https://doi.org/10.1016/j.jglr.2017.01.005
- Discipline:
- Science and Social Sciences
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University of Michigan Museum of Zoology
User Collection- Creator:
- University of Michigan Museum of Zoology
- Description:
- The University of Michigan Museum of Zoology (UMMZ) is the center for the study of animal diversity on campus, focusing on the evolutionary origins of the planet’s animal species, the genetic information they contain and the communities and ecosystems they help form. Now an integral part of the Department of Ecology and Evolutionary Biology (EEB), the UMMZ houses world-class collections, containing more than 15 million specimens, span almost 200 years of regional and global biodiversity studies and that support a multi-faceted Departmental research and teaching program.
- Discipline:
- Science
4Sub-collections0Works -
- Creator:
- Reynolds, Mack B., Hong, Hanna S., Zhang, Li, Lyssiotis, Costas A., and O'Riordan, Mary X.
- Description:
- Untargeted lipidomics (Data S1) and targeted metabolomics (Data S2) analysis from in vitro culture of a murine macrophage cell line expressing shRNA targeted to Cardiolipin synthase (CRLS1), referred to as CRLS1 knockdown (KD), or a paired non-target shRNA-expressing (NT-Control). CRLS1 KD and NT-Control macrophages were either directly analyzed (untargeted lipidomics) or stimulated with lipopolysaccharide for a variety of timepoints and then analyzed (targeted metabolomics). Datasets are available as .csv files.
- Keyword:
- Lipidomics, Metabolomics, Cardiolipin, Macrophage, CRLS1, lipopolysaccharide, and LPS
- Citation to related publication:
- Reynolds M.B. et al. (2023). Cardiolipin coordinates inflammatory metabolic reprogramming through regulation of Complex II disassembly and degradation. Science Advances, 9(5). DOI: 10.1126/sciadv.ade8701
- Discipline:
- Health Sciences
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- Creator:
- Skerlos, Steven J.
- Description:
- Supporting Information for research article "Life cycle comparison of environmental emissions from three disposal options for unused pharmaceutical". This spreadsheet provides the calculations and values used for this study; please refer to the manuscript and supporting information (as text) available at http://dx.doi.org/10.1021/es203987b for details about how to use this spreadsheet. We use life cycle assessment methodology to compare three disposal options for unused pharmaceuticals: (i) incineration after take-back to a pharmacy, (ii) wastewater treatment after toilet disposal, and (iii) landfilling or incineration after trash disposal. For each option, emissions of active pharmaceutical ingredients to the environment (API emissions) are estimated along with nine other types of emissions to air and water (non-API emissions). Under a scenario with 50% take-back to a pharmacy and 50% trash disposal, current API emissions are expected to be reduced by 93%. This is within 6% of a 100% trash disposal scenario, which achieves an 88% reduction. The 50% take-back scenario achieves a modest reduction in API emissions over a 100% trash scenario while increasing most non-API emissions by over 300%. If the 50% of unused pharmaceuticals not taken-back are toileted instead of trashed, all emissions increase relative to 100% trash disposal. Evidence suggests that 50% participation in take-back programs could be an upper bound. As a result, we recommend trash disposal for unused pharmaceuticals. A 100% trash disposal program would have similar API emissions to a take-back program with 50% participation, while also having significantly lower non-API emissions, lower financial costs, higher convenience, and higher compliance rates.
- Citation to related publication:
- Cook, Sherri M., Bryan J. VanDuinen, Nancy G. Love, and Steven J. Skerlos. “Life Cycle Comparison of Environmental Emissions from Three Disposal Options for Unused Pharmaceuticals.” Environmental Science & Technology 46, no. 10 (May 15, 2012): 5535–41. https://doi.org/10.1021/es203987b
- Discipline:
- Engineering
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- Creator:
- Mohtat, Peyman, Siegel, Jason B., Stefanopoulou, Anna G., and Lee, Suhak
- Description:
- The focus of this research effort is to systematically study the capability of aging diagnostics using cell expansion under variety of aging conditions and states. The data collection campaign is very important to cover various degradation modes to extract the degradation features that will be used to inform, parameterize, and validate the models developed earlier. In the data collection campaign, we are documenting the evolution of the electrical and mechanical characteristics and especially the reversible mechanical measurement. It is important to note that we collect data using newly developed fixtures that enables the simultaneous measurement of mechanical and electrical response under pseudo-constant pressure.
- Keyword:
- Lithium-ion batteries, Mechanical response, Aging, NMC, and Pouch cells
- Citation to related publication:
- Peyman Mohtat et al. (2021). Reversible and Irreversible Expansion of Lithium-ion Batteries Under a Wide Range of Stress Factors. J. Electrochem. Soc. 168 100520 https://doi.org/10.1149/1945-7111/ac2d3e
- Discipline:
- Engineering
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- Creator:
- Mohtat, Peyman, Siegel, Jason B., and Stefanopoulou, Anna G.
- Description:
- The goal here is to study the voltage and expansion response of lithium-ion batteries at different charging rates. Specifically, the goal is to capture the observation of the smoothing of the peaks in dV/dQ and retention of the peaks in d^2 (backslash)delta/dQ^2 at higher C-rates. The retention of the peaks at higher charging rates enables better estimation of the cell capacity. To achieve this goal a reduced order electrochemical and mechanical model with multiple particles with a size distribution is developed. This allows us to capture the smoothing and preservation of the phase transitions in the voltage and expansion measurements at high C-rates, respectively. The model is written in Matlab software.
- Keyword:
- Lithium-ion batteries, Modeling, Multiparticle, Mechanical response, and Electrochemical
- Citation to related publication:
- Mohtat, P., Lee, S., Sulzer, V., Siegel, J. B., & Stefanopoulou, A. G. (2020). Differential Expansion and Voltage Model for Li-ion Batteries at Practical Charging Rates. Journal of The Electrochemical Society, 167(11), 110561. https://doi.org/10.1149/1945-7111/aba5d1
- Discipline:
- Engineering
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- Creator:
- Ma, Sicong and Keane, Sarah
- Description:
- These files are the original data for the publication of 'Use of steric blocking antisense oligonucleotides for the targeted inhibition of junction containing precursor microRNAs': https://doi.org/10.1101/2024.04.08.588531. This dataset contains the original gel image files for the processing assay results, luciferase data readout, and the original data file for qPCR results reported in the publication.
- Citation to related publication:
- Use of steric blocking antisense oligonucleotides for the targeted inhibition of junction containing precursor microRNAs Sicong Ma, Samantha A. Howden, Sarah C. Keane bioRxiv 2024.04.08.588531; doi: https://doi.org/10.1101/2024.04.08.588531
- Discipline:
- Science
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- Creator:
- Eckel, Catherine, Hoover, Hanna, Krupka, Erin, Sinha, Nishita, and Wilson, Rick
- Description:
- The research reported here is part of a larger study where we recruited students from the entering undergraduate classes in 2016, 2017, 2018 and 2019 at Rice University. The aim of the larger project is to examine the evolution of economic preferences (altruism, risk aversion, time preference, competitiveness, loss aversion, in-group favoritism, among others) across their college years. Subjects participated in numerous laboratory and online studies between matriculation and 2021. This paper uses data from the experimental design of a subset of tasks that subjects completed. The survey wave used in this paper was collected in June and July of 2021. This survey was composed of fifteen modules and had a total of 710 participants. and The survey consisted of 15 modules. Module 1 consisted of questions on COVID-19 related behavior and future expectations of the COVID-19 pandemic. Module 2 consisted of an emotion elicitation task. Module 3 solicited trust levels of several authorities and news outlets. Module 4 consisted of several general socioeconomic preference questions. Module 5 asked questions related to how frequently subjects provide various forms of help. Module 6 solicited social appropriateness ratings regarding COVID-19 preventative behavior. Module 7 consisted of an estimation task. Module 8 was the dictator game with the freshmen recipient. Module 9 involved a risky investment decision task. Module 10 was the dictator game with the same-class recipient. Module 11 involved a trust-game. Module 12 was the dictator game with charity as the recipient. Module 13 asked questions regarding help received by the university as well as COVID-19 academic impact. Module 14 included questions regarding the subjects’ COVID-19 infection status. Module 15 posed questions regarding subjects’ resiliency. Only modules 8, 10, and 12 were used in this analysis. These corresponded to Q11 - Q18 of the instrument. In each module, subjects played a dictator game, guessed what others did in the game and played a coordination game designed to elicit norms for the dictator game they just played. After the subject completed the survey, we randomly selected a module for payment. Subjects then received an email alerting the subject which module was selected for payment and how much money they would receive given their responses in the selection module. Data was analyzed using STATA; if running the do file for STATA, and not already installed, then add ""capture ssc install estout" to the very top of the .do file.
- Keyword:
- Dictator game, Social norms, and Charitable giving
- Discipline:
- Social Sciences
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- Creator:
- Billings, Gideon H and Johnson-Roberson, Matthew
- Description:
- UWHandles is a dataset for 6D object pose estimation in underwater fisheye images. It provides 6D pose and 2D bounding box annotations for 3 different graspable handle objects used for ROV manipulation. The dataset consists of 28 image sequences collected in natural seafloor environments with a total of 20,427 annotated frames. and Meta repository for the dataset https://github.com/gidobot/UWHandles
- Keyword:
- Deep Learning, Pose Estimation, and Underwater Vision
- Citation to related publication:
- Billings, G., & Johnson-Roberson, M. (2020). SilhoNet-fisheye: Adaptation of a ROI based object pose estimation network to monocular fisheye images. IEEE Robotics and Automation Letters, 5(3), 4241-4248.
- Discipline:
- Engineering