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- Creator:
- Hatch, Nan E.
- Description:
- Craniosynostosis is the premature fusion of cranial bones. The goal of this study was to determine if delivery of recombinant tissue nonspecific alkaline phosphatase (TNAP) could prevent or diminish the severity of craniosynostosis in a C57BL/6 FGFR2C342Y/+ model of neonatal onset craniosynostosis or a BALB/c FGFR2C342Y/+ model of postnatal onset craniosynostosis. Mice were injected with a lentivirus encoding a mineral targeted form of TNAP immediately after birth. Cranial bone fusion as well as cranial bone volume, mineral content and density were assessed by micro computed tomography. Craniofacial shape was measured with calipers., Alkaline phosphatase, alanine amino transferase (ALT) and aspartate amino transferase (AST) activity levels were measured in serum. Neonatal delivery of TNAP diminished craniosynostosis severity from 94% suture obliteration in vehicle treated mice to 67% suture obliteration in treated mice, p<0.02) and the incidence of malocclusion from 82.4% to 34.7% (p<0.03), with no effect on cranial bone in C57BL/6 FGFR2C342Y/+ mice. In contrast, treatment with TNAP improved cranial bone volume (p< 0.01), density (p< 0.01) and mineral content (p< 0.01) but had no effect on craniosynostosis or malocclusion in BALB/c FGFR2C342Y/+ mice. , These results indicate that post-natal recombinant TNAP enzyme therapy diminishes craniosynostosis severity in the C57BL/6 FGFR2C342Y/+ neonatal onset mouse model of Crouzon syndrome, and that effects of exogenous TNAP are genetic background dependent., and Included in this collection is one set of images representing the C57BL/6 FGFR2C342Y/+ model of neonatal onset craniosynostosis, and one for the BALB/c FGFR2C342Y/+ model of postnatal onset craniosynostosis
- Keyword:
- craniofacial, bone, craniosynostosis, FGFR2, TNAP, mouse model, and development
- Discipline:
- Health Sciences
2Works -
Vani Region Archaeological Survey
User Collection- Creator:
- Ratte, Christopher and Mokrisova, Jana
- Description:
- The data presented here were collected in the course of an archaeological survey of the region around Vani in the Republic of Georgia, carried out between 2009 and 2011, with follow-up visits in 2014 and 2017. The survey was sponsored by the University of Michigan, the Institute for the Study of the Ancient World at New York University, and the Otar Lordkipanidze Institute of Archaeological Research in Tbilisi. , The archaeological site of Vani lies in the territory of ancient Colchis, a triangular area bordered by the Black Sea to the west and by the greater and lesser Caucasus Mountains to the north and south – famous in Greek legend as the land of the Golden Fleece and the home of Medea. Vani itself is situated approximately 70 km inland, in the foothills of the lesser Caucasus. A regional culture recognizable on the evidence of distinctive traditions of pottery and metalworking and the appearance of a network of relatively large settlements had emerged in Colchis by the late second and early first millennia BC. , Vani is one of the most extensively studied archaeological sites in Colchis. Excavations have revealed a continuous occupation sequence extending from the 8th to the 1st centuries B.C. Especially notable are the rich and unusual graves of the Classical period (6th-4th centuries), the monumental stone architecture of the Hellenistic period (3rd to 1st centuries), especially fortifications enclosing an area of approximately 6 ha, and the extensive evidence for interaction with the Mediterranean and Near Eastern worlds, including not only commercial and luxury imports (Greek transport amphorae, fine bronze and silver utensils from both the Greek world and Persia), but also local production of bronze sculpture and one long Greek bronze inscription., In spite of the richness of the site, however, important questions about its purpose and function over time remain unresolved. How extensive was the ancient settlement? Was Vani an isolated stronghold, a regional population center, a sanctuary, or a combination of two or all three? How does it compare with other sites in Colchis? In addition to ongoing research at Vani itself, regional survey provides an obvious approach to some of these questions. In previous years, examination of a number of outlying sites had already yielded remains extending in date from the Early Bronze Age to the mediaeval period., and The purpose of the regional survey project begun in 2009 was to integrate existing knowledge about Vani and environs into the kind of technological and conceptual framework characteristic of contemporary American survey archaeology. Of particular importance was the use of Geographical Information Systems (GIS) as an organizational and analytical tool, and of geophysical prospection both in the immediate environs of Vani and at regional sites. Like all regional surveys, our project recorded evidence of all periods, from prehistory to the present day, but we were particularly interested in questions having to do with the increasing social complexity of Colchis in the mid- and later 1st millennium BC – when Greek explorers began to establish colonies on the Black Sea coast of Georgia, and the Persian empire pushed up against the mountains of the Caucasus. What was the nature of Colchian society in this period? How was it affected by interaction with the larger Greek, Persian, and Pontic worlds? And how can regional survey at Vani and throughout Colchis help us to address these questions?
- Keyword:
- Classical Archaeology, Fortifications, Churches, Sanctuaries, Quarries, Modern Settlements, Settlements, and Burials
- Discipline:
- Humanities
25Sub-collections1Works -
Transmission of Oral microbiome and Sequencing
User Collection- Creator:
- Lee, Kyu Han
- Description:
- De-identified participant data from household transmission study of influenza in Nicaragua Oligotype count table and taxonomic classifications
- Keyword:
- Influenza and Microbiome
- Discipline:
- Health Sciences
2Works -
S’Urachi Site-Based Archaeological Survey
User Collection- Creator:
- Gosner, Linda R.
- Description:
- This data was produced by the site-based archaeological survey at the nuraghe S'Urachi in west-central Sardinia (San Vero Milis, Oristano, Sardinia). The survey was carried out from 2015-2017 as a part of the ongoing Progetto S'Urachi, an archaeological project that aims to understand daily life around the monumental Bronze Age tower of S'Urachi during the later occupation of the landscape over the course of the 1st millennium BCE.
- Keyword:
- Mediterranean archaeology, Sardinia, Archaeological Survey, Excavation, and Classical Archaeology
- Discipline:
- Social Sciences
2Works -
Survey Data
User Collection- Creator:
- Galaty, Michael
- Description:
- All databases, field notebooks, paper maps, GIS files, photographs, and photo descriptions related to the intensive survey, of tracts and tumuli, and the collection of sites have been made available in PASH Deep Blue Data Realm 1. The data are broadly organized by team (A-K). The surveyed land was divided up into “tracts”. Tracts are labeled with team letter and a consecutive number: e.g., A-001, A-002, B-003, C-122, D-035.
- Keyword:
- Archaeology
- Discipline:
- Science
6Works -
Resources for Training Machine Learning Algorithms Using CAM6 Simple Physics Packages
User Collection- Creator:
- Limon, Garrett
- Description:
- The collection contains the code and the data used to train machine learning algorithms to emulate simplified physical parameterizations within the Community Atmosphere Model (CAM6). CAM6 is the atmospheric general circulation model (GCM) within the Community Earth System Model (CESM) framework, developed by the National Center for Atmospheric Research (NCAR). GCMs are made up of a dynamical core, responsible for the geophysical fluid flow calculations, and physical parameterization schemes, which estimate various unresolved processes. Simple physics schemes were used to train both random forests and neural networks in the interest of exploring the feasibility of machine learning techniques being used in conjunction with the dynamical core for improved efficiency of future climate and weather models. The results of the research show that various physical forcing tendencies and precipitation rates can be effectively emulated by the machine learning models.
- Keyword:
- Machine Learning, Climate Modeling, and Physics Emulators
- Discipline:
- Science and Engineering
2Works -
- Creator:
- Wang, Yi and Hendy, Ingrid
- Description:
- This collection represents various raw data and analysis of cores extracted during the January 2009 mission of the research vessel Sproul in the Santa Barbara Basin., Cores included: box core SPR0901-04BC, box core SPR0901-unnamed, and Kasten core SPR0901-03KC. Core photos, physical properties and magnetic susceptibility from the multisensor track (MST), and the scanning X-ray fluorescence (XRF) data are included in the collection., and Cruise DOI: 10.7284/901089 This research is funded by NSF-OCE 0752093.
- Keyword:
- Santa Barbara Basin, Southern California, core photos, physical properties, scanning XRF, SPR0901, and Earth Science
- Discipline:
- Science
8Works -
R/V Melville Core Retrieval Campaign (MV0811), November 2008
User Collection- Creator:
- Wang, Yi and Hendy, Ingrid
- Description:
- This collection represents various raw data and analysis of cores extracted during the November 2008 mission of R/V Melville in the Santa Barbara Basin., The core included is the jumbo piston core MV0811-14JC. Core photos, physical properties and magnetic susceptibility from the multisensor track (MST), and the scanning X-ray fluorescence (XRF) data are included in the collection., and Cruise DOI: 10.7284/903459 The research is funded by NSF OCE-1304327.
- Keyword:
- Santa Barbara Basin, Southern California, core photos, physical properties, scanning XRF, MV0811, and Earth Science
- Discipline:
- Science
3Works -
- Creator:
- Yan, Xiang (Jacob), Clarke, Phillipa J., Okullo, Dolorence, Goodspeed, Robert, Data Driven Detroit, Gomez-Lopez, Iris N., and Veinot, Tiffany C
- Description:
- This collection was produced as part of the project, “A ‘Big Data’ Approach to Understanding Neighborhood Effects in Chronic Illness Disparities.” The Investigators for the project are Tiffany Veinot, Veronica Berrocal, Phillipa Clarke, Robert Goodspeed, Daniel Romero, and VG Vinod Vydiswaran from the University of Michigan. The study took place from 2015-2016, with funding from the University of Michigan’s Social Sciences Annual Institute, MCubed, and the Sloan and Moore Foundations. Contact: Tiffany Veinot, MLS, PhD Office: 3443 North Quad Phone: 734/615-8281 Email: tveinot@umich.edu MCubed project page: https://mcubed.umich.edu/projects/%E2%80%9Cbig-data%E2%80%9D-approach-understanding-neighborhood-effects-chronic-illness-disparities
- Keyword:
- Food Environment, Health Status, Employment, Health Care Resources, Neighborhood Safety, Healthcare Utilization, Transportation, Census tract level, Information and Education Environment, Spatial Measures, Detroit, Active Living Resources, Social Environment, Demographics, Community Health, Housing, and student-friendly
- Discipline:
- Social Sciences
6Works -
Mali flora images
User Collection- Creator:
- Heath, Jeffrey G.
- Description:
- These images of plants, in nature or as fresh or dried specimens, were made in conjunction with research on languages of the Dogon and Bozo families, along with the isolated language Bangime, in Central Mali between 2006 and 2023. (See also the work "Dogon and Bangime flora terms from central Mali (2023)" in Deep Blue Data: https://doi.org/10.7302/34vf-jk03. The late Pierre Poilecot of CNRS (Montpellier, France) provided invaluable help in the early days. However, I am responsible for the determinations (including taxonomic updates), and I am not a professional botanist. The images range from poor to excellent technical quality. They may be of use for two purposes: a) acquiring a basic knowledge of the flora of the area, for newcomers; b) as vouchers for the determinations in my lexical spreadsheets on the various languages. While the main burst of taxonomic changes due to molecular studies has probably leveled off as of 2023, some revisions at all levels (family, genus, species) will occur over time. The African Flowering Plant Database at url https://africanplantdatabase.ch is especially useful for updates/synonymies at the species level, but tends to lag behind on revisions at the family level., Each "work" for flowering plants in this collection has the title "Mali flora images X" where X is the name of a botanical family. Users who enter at the collection level should search by family (from Acanthacaceae to Zypɣophyllaceae). Large families Poaceae, Malvaceae, and Fabaceae are divided into two or more works, but they will all show up in search results for the family. There is one work for non-flowering plants with title "Mali aa fern fungus lichen images"., Within each work, the individual images have file names like these: fl_Amaranthaceae_Celosia_trigyna_Beni_10_2011_fl_50035_JH.JPG fl_Lamiaceae_Hoslundia_opposita_Barato_09_2021_piripirinaw_03_fol_fr_JH.JPG fl_Zygophyllaceae_Tribulus_terrestris_Sevare_patch_50672_JH.tif fl_Fabaceae_Caesalpinioideae_mimosoid_Vachellia_(or_Acacia)_nilotica fuwON_1_Barato_09_2021_entire_JH.JPG They begin with "fl" for flora, the family, the genus, and the species epithet. For Fabaceae, the subfamily and if relevant "mimosoid" (part of subfamily Caesalpinioideae) precedes the genus. These items are separated by underlines (important to note if searching for a genus-species binomial). The remaining items were mostly for my own use. They may include a location (on which see the following paragraph), the date, a crude representation (without IPA symbols or diacritics) of a native name, a five-digit code for my use, a photo number like "2" for the same plant, "JH" to indicate that the image was taken by me or by a member of a project I directed, jpg or occasionally tif for forrmat, and an indicator of what part of the plant is shown: entire, bark, fl[ower], fol[iage], lf (leaf), fr[uit], tr[unk], br[anch], th[orn]. File names can be quite long especially for Fabaceae because of the subfamily names. In lists of files under such works, the file name may be shown in abbreviated form (with ellipsis ...) so that the genus and species terms may not be visible. The only way to find files for a particular species is by searching for that species. Alternatively, all of the files in a work can be downloaded in zip form and users can then see complete file names. The readme's for each work list the included species. , Most of the locations indicated are in the Dogon-speaking area, which includes cliffs, high plateaus, inselbergs, sandy plains, seasonal rivers, and small ponds. Dogon locations include Beni, Tupere, Ségué, Bendiely, Dianwely, Anda, Walo, and Tongo Tongo, among others. The inselbergs and adjoining plains of the montane Songhay are represented mainly by Hombori and Kikara. The Niger and Bani river zone from Mopti to Segou, a mainly Bozo-speaking area that features seasonal floodplains, is represented mainly by Djenne, Barato, and Kolongo. , and Some of these plants are featured in documentary-style videos. There are two collections of such videos from Mali in Deep Blue Data: Mali documentary videos from 2023 - https://doi.org/10.7302/4851-2c52 Central Mali documentary videos - https://doi.org/10.7302/4jg9-j095 Additional flora-related videos from Mali may be archived at a later date. Some fauna images may also be archived at a later date. The various Mali collections (flora, videos) will be paralleled in time by comparable collections for southwestern Burkina Faso, and small collections for north-central Côte d'Ivoire, all in Deep Blue Data.
- Keyword:
- flora and Central Mali
- Discipline:
- Humanities
97Works