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- Creator:
- Brinkmeier, Michelle L, Wang, Su Qing, Pittman, Hannah, Cheung, Leonard Y, and Prasov, Lev
- Description:
- MYRF is a gene that regulates the development and function of the retinal pigmented epithelium (RPE), which play an important role in maintaining photoreceptor structure and function. Mutations in patients have been implicated in eye size disorders, particularly causing a small, but structurally normal eye. We have utilized a molecular technique, single cell RNA sequencing, to investigate how loss of Myrf specifically in the RPE in a mouse model impacts downstream gene expression at three developmental timepoints and used this information to define the role of Myrf in development. Our work identified key cytoskeletal structural genes specific to the RPE, Ermn and Upk3b, and a gene important for the cell survival, Sox10, as critical targets of Myrf. In addition, we have identified and confirmed that the TGFbeta signaling pathway is dysregulated when Myrf is lost during development. This pathway is particularly relevant in RPE health and eye growth. Our electron microscopy and histologic analyses also confirm a defect in RPE structure and function. We place MYRF within a hierarchy of genes involved in RPE development and introduce novel candidate genes for further study as retinal degeneration and nanophthalmos candidate genes.
- Keyword:
- ERMN, MYRF, Hypopigmentation, TMEM98, SOX10, Retinal Pigment Epithelium (RPE), and Retinal degeneration
- Discipline:
- Science
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- Creator:
- University of Michigan Museum of Zoology
- Description:
- Scan of specimen ummz:herps:238369 (NOTOTRITON PICADOI) - Limbs. Raw Dataset includes 1601 TIF images (each 461 x 741 x 1 voxel at 0.01300206 mm resolution, derived from 1601 scan projections), xtek and vgi files for volume reconstruction. and Scan of specimen ummz:herps:238369 (NOTOTRITON PICADOI) - Limbs. Reconstructed Dataset includes 0.013002 TIF images (each 461 x 741 x 1 voxel at 0.013002 mm resolution, derived from 1601 scan projections), xtek and vgi files for volume reconstruction.
- Keyword:
- Animalia, Chordata, Amphibia, CAUDATA, PLETHODONTIDAE, NOTOTRITON PICADOI, 1987030882, computed tomography, X-ray, and 3D
- Citation to related publication:
- For more information on the original UMMZ specimen, see: https://www.gbif.org/occurrence/1987030882
- Discipline:
- Science
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- Creator:
- University of Michigan Museum of Zoology
- Description:
- Scan of specimen ummz:herps:194448 (PSEUDOTRITON RUBER) - Limbs. Raw Dataset includes 1601 TIF images (each 372 x 652 x 1 voxel at 0.03100344 mm resolution, derived from 1601 scan projections), xtek and vgi files for volume reconstruction. and Scan of specimen ummz:herps:194448 (PSEUDOTRITON RUBER) - Limbs. Reconstructed Dataset includes 0.031003 TIF images (each 372 x 652 x 1 voxel at 0.031003 mm resolution, derived from 1601 scan projections), xtek and vgi files for volume reconstruction.
- Keyword:
- Animalia, Chordata, Amphibia, CAUDATA, PLETHODONTIDAE, PSEUDOTRITON RUBER, 1987126336, computed tomography, X-ray, and 3D
- Citation to related publication:
- For more information on the original UMMZ specimen, see: https://www.gbif.org/occurrence/1987126336
- Discipline:
- Science
-
- Creator:
- University of Michigan Museum of Zoology
- Description:
- Scan of specimen ummz:herps:143736 (PSEUDOEURYCEA BELLII) - Limbs. Raw Dataset includes 1601 TIF images (each 642 x 2000 x 1 voxel at 0.02199678 mm resolution, derived from 1601 scan projections), xtek and vgi files for volume reconstruction., Scan of specimen ummz:herps:143736 (PSEUDOEURYCEA BELLII) - Limbs. Reconstructed Dataset includes 0.021997 TIF images (each 642 x 2000 x 1 voxel at 0.021997 mm resolution, derived from 1601 scan projections), xtek and vgi files for volume reconstruction., and Scan of specimen ummz:herps:143736 (PSEUDOEURYCEA BELLII) - Limbs. Reconstructed Dataset includes 0.021997 TIF images (each 642 x 2000 x 1 voxel at 0.021997 mm resolution, derived from 1601 scan projections), xtek and vgi files for volume reconstruction.
- Keyword:
- Animalia, Chordata, Amphibia, CAUDATA, PLETHODONTIDAE, PSEUDOEURYCEA BELLII, 1987206748, computed tomography, X-ray, and 3D
- Citation to related publication:
- For more information on the original UMMZ specimen, see: https://www.gbif.org/occurrence/1987206748
- Discipline:
- Science
-
- Creator:
- University of Michigan Museum of Zoology
- Description:
- Scan of specimen ummz:herps:137395 (OEDIPINA POELZI) - Limbs. Raw Dataset includes 1601 TIF images (each 514 x 670 x 1 voxel at 0.02500204 mm resolution, derived from 1601 scan projections), xtek and vgi files for volume reconstruction. and Scan of specimen ummz:herps:137395 (OEDIPINA POELZI) - Limbs. Reconstructed Dataset includes 0.025002 TIF images (each 514 x 670 x 1 voxel at 0.025002 mm resolution, derived from 1601 scan projections), xtek and vgi files for volume reconstruction.
- Keyword:
- Animalia, Chordata, Amphibia, CAUDATA, PLETHODONTIDAE, OEDIPINA POELZI, 1987178002, computed tomography, X-ray, and 3D
- Citation to related publication:
- For more information on the original UMMZ specimen, see: https://www.gbif.org/occurrence/1987178002
- Discipline:
- Science
-
- Creator:
- University of Michigan Museum of Zoology
- Description:
- Scan of specimen ummz:herps:126557A (STEREOCHILUS MARGINATUS) - Limbs. Raw Dataset includes 1601 TIF images (each 322 x 588 x 1 voxel at 0.01900397 mm resolution, derived from 1601 scan projections), xtek and vgi files for volume reconstruction. and Scan of specimen ummz:herps:126557A (STEREOCHILUS MARGINATUS) - Limbs. Reconstructed Dataset includes 0.019004 TIF images (each 322 x 588 x 1 voxel at 0.019004 mm resolution, derived from 1601 scan projections), xtek and vgi files for volume reconstruction.
- Keyword:
- Animalia, Chordata, Amphibia, CAUDATA, PLETHODONTIDAE, STEREOCHILUS MARGINATUS, 1987059875, computed tomography, X-ray, and 3D
- Citation to related publication:
- For more information on the original UMMZ specimen, see: https://www.gbif.org/occurrence/1987059875
- Discipline:
- Science
-
- Creator:
- University of Michigan Museum of Zoology
- Description:
- Scan of specimen ummz:herps:119705 (THORIUS MACDOUGALLI) - Limbs. Raw Dataset includes 1601 TIF images (each 499 x 1109 x 1 voxel at 0.00900072 mm resolution, derived from 1601 scan projections), xtek and vgi files for volume reconstruction. and Scan of specimen ummz:herps:119705 (THORIUS MACDOUGALLI) - Limbs. Reconstructed Dataset includes 0.009001 TIF images (each 499 x 1109 x 1 voxel at 0.009001 mm resolution, derived from 1601 scan projections), xtek and vgi files for volume reconstruction.
- Keyword:
- Animalia, Chordata, Amphibia, CAUDATA, PLETHODONTIDAE, THORIUS MACDOUGALLI, 1987144849, computed tomography, X-ray, and 3D
- Citation to related publication:
- For more information on the original UMMZ specimen, see: https://www.gbif.org/occurrence/1987144849
- Discipline:
- Science
-
- Creator:
- University of Michigan Museum of Zoology
- Description:
- Scan of specimen ummz:herps:119705 (THORIUS MACDOUGALLI) - Limbs. Raw Dataset includes 3141 TIF images (each 658 x 1194 x 1 voxel at 0.00700461 mm resolution, derived from 3141 scan projections), xtek and vgi files for volume reconstruction. and Scan of specimen ummz:herps:119705 (THORIUS MACDOUGALLI) - Limbs. Reconstructed Dataset includes 0.007005 TIF images (each 658 x 1194 x 1 voxel at 0.007005 mm resolution, derived from 3141 scan projections), xtek and vgi files for volume reconstruction.
- Keyword:
- Animalia, Chordata, Amphibia, CAUDATA, PLETHODONTIDAE, THORIUS MACDOUGALLI, 1987144849, computed tomography, X-ray, and 3D
- Citation to related publication:
- For more information on the original UMMZ specimen, see: https://www.gbif.org/occurrence/1987144849
- Discipline:
- Science
-
- Creator:
- University of Michigan Museum of Zoology
- Description:
- Scan of specimen ummz:herps:118145 (PARVIMOLGE TOWNSENDI) - Limbs. Raw Dataset includes 1601 TIF images (each 945 x 437 x 1 voxel at 0.01000111 mm resolution, derived from 1601 scan projections), xtek and vgi files for volume reconstruction. and Scan of specimen ummz:herps:118145 (PARVIMOLGE TOWNSENDI) - Limbs. Reconstructed Dataset includes 0.010001 TIF images (each 945 x 437 x 1 voxel at 0.010001 mm resolution, derived from 1601 scan projections), xtek and vgi files for volume reconstruction.
- Keyword:
- Animalia, Chordata, Amphibia, CAUDATA, PLETHODONTIDAE, PARVIMOLGE TOWNSENDI, 1987119774, computed tomography, X-ray, and 3D
- Citation to related publication:
- For more information on the original UMMZ specimen, see: https://www.gbif.org/occurrence/1987119774
- Discipline:
- Science
-
- Creator:
- University of Michigan Museum of Zoology
- Description:
- Scan of specimen ummz:herps:115164 (THORIUS PENNATULUS) - Limbs. Raw Dataset includes 3141 TIF images (each 536 x 910 x 1 voxel at 0.00899784 mm resolution, derived from 3141 scan projections), xtek and vgi files for volume reconstruction. and Scan of specimen ummz:herps:115164 (THORIUS PENNATULUS) - Limbs. Reconstructed Dataset includes 0.008998 TIF images (each 536 x 910 x 1 voxel at 0.008998 mm resolution, derived from 3141 scan projections), xtek and vgi files for volume reconstruction.
- Keyword:
- Animalia, Chordata, Amphibia, CAUDATA, PLETHODONTIDAE, THORIUS PENNATULUS, 1987108055, computed tomography, X-ray, and 3D
- Citation to related publication:
- For more information on the original UMMZ specimen, see: https://www.gbif.org/occurrence/1987108055
- Discipline:
- Science