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- Creator:
- Ludlow, Andrew
- Description:
- Single molecule long read RNA/cDNA sequencing of TERT revealed 45 TERT mRNA variants including 13 known and 32 novel variants. Among the variants, TERT Delta 2-4, which lacks exons 2-4 but retains the original open reading frame, was selected for further study. Induced pluripotent stem cells and cancer cells express higher levels of TERT Delta 2-4 compared to primary human bronchial epithelial cells. Overexpression of TERT Delta 2-4 enhanced clonogenicity and resistance to cisplatin-induced apoptosis. Knockdown of endogenous TERT Delta 2-4 in Calu-6 cells reduced clonogenicity and resistance to cisplatin. Our results suggest that TERT Delta 2-4 enhances cancer cells’ resistance to intrinsic apoptosis. RNA sequencing following knockdown of Delta 2-4 TERT indicates that translation is downregulated and that mitochondrial related proteins are upregulated compared to controls.
- Keyword:
- TERT, Alternative splicing, Telomere, and Telomerase
- Discipline:
- Science
-
- Creator:
- University of Michigan Museum of Paleontology and CTEES
- Description:
- Reconstructed CT slices for Slabs of Vertebrate (University of Michigan Museum of Paleontology catalog number UMMP VP 119342etseq) as a series of TIFF images. Raw projections are not included in this dataset. The reconstructed slice data from the scan are offered here as a series of unsigned 16-bit integer TIFF images. The upper left corner of the first image (*_0000.tif) is the XYZ origin.
- Keyword:
- Paleontology, Fossil, CT, CTEES, UMMP, University of Michigan Museum of Paleontology, Vertebrate, Paleonisciform, Actinopterygii, Sarcopterygii, Chondrichthyes, Marshall Sandstone , Mississippian, and Carboniferous
- Citation to related publication:
- JAMES V. ANDREWS, ETHAN A. SHIRLEY, AND RODRIGO T. FIGUEROA. VERTEBRATES OF THE BLUE RIDGE ESKER (MISSISSIPPIAN, MARSHALL SANDSTONE) OF MICHIGAN. Contributions from the Museum of Paleontology, University of Michigan, Vol. 36, no. 3, pp. 1–16, 2024
- Discipline:
- Science
-
- Creator:
- University of Michigan Museum of Paleontology and CTEES
- Description:
- Reconstructed CT slices for Slabs of Vertebrate (University of Michigan Museum of Paleontology catalog number UMMP VP 119342etseq) as a series of TIFF images. Raw projections are not included in this dataset. The reconstructed slice data from the scan are offered here as a series of unsigned 16-bit integer TIFF images. The upper left corner of the first image (*_0000.tif) is the XYZ origin.
- Keyword:
- Paleontology, Fossil, CT, Vertebrate, Actinopterygii, Sarcopterygii, Paleonisciform, Carboniferous, Chondrichthyes, UMMP, University of Michigan Museum of Paleontology, Marshall Sandstone, Mississippian, and CTEES
- Citation to related publication:
- JAMES V. ANDREWS, ETHAN A. SHIRLEY, AND RODRIGO T. FIGUEROA. VERTEBRATES OF THE BLUE RIDGE ESKER (MISSISSIPPIAN, MARSHALL SANDSTONE) OF MICHIGAN. Contributions from the Museum of Paleontology, University of Michigan, Vol. 36, no. 3, pp. 1–16, 2024
- Discipline:
- Science
-
- Creator:
- University of Michigan Museum of Paleontology and CTEES
- Description:
- Reconstructed CT slices for Slabs of Vertebrate (University of Michigan Museum of Paleontology catalog number UMMP VP 119342etseq) as a series of TIFF images. Raw projections are not included in this dataset. The reconstructed slice data from the scan are offered here as a series of unsigned 16-bit integer TIFF images. The upper left corner of the first image (*_0000.tif) is the XYZ origin.
- Keyword:
- Paleontology, Fossil, CT, Vertebrate, Actinopterygii, Sarcopterygii, Paleonisciform, Carboniferous, Chondrichthyes, UMMP, University of Michigan Museum of Paleontology, Marshall Sandstone, Mississippian, and CTEES
- Citation to related publication:
- JAMES V. ANDREWS, ETHAN A. SHIRLEY, AND RODRIGO T. FIGUEROA. VERTEBRATES OF THE BLUE RIDGE ESKER (MISSISSIPPIAN, MARSHALL SANDSTONE) OF MICHIGAN. Contributions from the Museum of Paleontology, University of Michigan, Vol. 36, no. 3, pp. 1–16, 2024
- Discipline:
- Science
-
- Creator:
- University of Michigan Museum of Paleontology and CTEES
- Description:
- Reconstructed CT slices for Slabs of Vertebrate (University of Michigan Museum of Paleontology catalog number UMMP VP 119342etseq) as a series of TIFF images. Raw projections are not included in this dataset. The reconstructed slice data from the scan are offered here as a series of unsigned 16-bit integer TIFF images. The upper left corner of the first image (*_0000.tif) is the XYZ origin.
- Keyword:
- Paleontology, Fossil, CT, CTEES, UMMP, University of Michigan Museum of Paleontology , Vertebrate, Paleonisciform, Actinopterygii, Sarcopterygii, Chondrichthyes, Marshall Sandstone , Mississippian , and Carboniferous
- Citation to related publication:
- JAMES V. ANDREWS, ETHAN A. SHIRLEY, AND RODRIGO T. FIGUEROA. VERTEBRATES OF THE BLUE RIDGE ESKER (MISSISSIPPIAN, MARSHALL SANDSTONE) OF MICHIGAN. Contributions from the Museum of Paleontology, University of Michigan, Vol. 36, no. 3, pp. 1–16, 2024
- Discipline:
- Science
-
- Creator:
- University of Michigan Museum of Paleontology and CTEES
- Description:
- Reconstructed CT slices for Slabs of Vertebrate (University of Michigan Museum of Paleontology catalog number UMMP VP 119342etseq) as a series of TIFF images. Raw projections are not included in this dataset. The reconstructed slice data from the scan are offered here as a series of unsigned 16-bit integer TIFF images. The upper left corner of the first image (*_0000.tif) is the XYZ origin.
- Keyword:
- Paleontology, Fossil, CT, CTEES, UMMP, University of Michigan Museum of Paleontology, Vertebrate, Paleonisciform, Actinopterygii, Sarcopterygii, Chondrichthyes, Marshall Sandstone , Mississippian, and Carboniferous
- Citation to related publication:
- JAMES V. ANDREWS, ETHAN A. SHIRLEY, AND RODRIGO T. FIGUEROA. VERTEBRATES OF THE BLUE RIDGE ESKER (MISSISSIPPIAN, MARSHALL SANDSTONE) OF MICHIGAN. Contributions from the Museum of Paleontology, University of Michigan, Vol. 36, no. 3, pp. 1–16, 2024
- Discipline:
- Science
-
- Creator:
- University of Michigan Museum of Paleontology and CTEES
- Description:
- Reconstructed CT slices for Spine of Stethacanthus (University of Michigan Museum of Paleontology catalog number UMMP VP 118281) as a series of TIFF images. Raw projections are not included in this dataset. The reconstructed slice data from the scan are offered here as a series of unsigned 16-bit integer TIFF images. The upper left corner of the first image (*_0000.tif) is the XYZ origin.
- Keyword:
- Paleontology, Fossil, CT, CTEES, UMMP, University of Michigan Museum of Paleontology , Vertebrate, Chondrichthyes, Marshall Sandstone, Mississippian, and Carboniferous
- Citation to related publication:
- JAMES V. ANDREWS, ETHAN A. SHIRLEY, AND RODRIGO T. FIGUEROA. VERTEBRATES OF THE BLUE RIDGE ESKER (MISSISSIPPIAN, MARSHALL SANDSTONE) OF MICHIGAN. Contributions from the Museum of Paleontology, University of Michigan, Vol. 36, no. 3, pp. 1–16, 2024
- Discipline:
- Science
-
- Creator:
- University of Michigan Museum of Paleontology and CTEES
- Description:
- Reconstructed CT slices for Slabs of Vertebrate (University of Michigan Museum of Paleontology catalog number UMMP VP 119343) as a series of TIFF images. Raw projections are not included in this dataset. The reconstructed slice data from the scan are offered here as a series of unsigned 16-bit integer TIFF images. The upper left corner of the first image (*_0000.tif) is the XYZ origin.
- Keyword:
- Paleontology, Fossil, CT, CTEES, UMMP, University of Michigan Museum of Paleontology, Vertebrate, Chondrichthyes, Marshall Sandstone, Mississippian, and Carboniferous
- Citation to related publication:
- JAMES V. ANDREWS, ETHAN A. SHIRLEY, AND RODRIGO T. FIGUEROA. VERTEBRATES OF THE BLUE RIDGE ESKER (MISSISSIPPIAN, MARSHALL SANDSTONE) OF MICHIGAN. Contributions from the Museum of Paleontology, University of Michigan, Vol. 36, no. 3, pp. 1–16, 2024
- Discipline:
- Science
-
- Creator:
- University of Michigan Museum of Paleontology and CTEES
- Description:
- Reconstructed CT slices for Slabs of Vertebrate (University of Michigan Museum of Paleontology catalog number UMMP VP 119346) as a series of TIFF images. Raw projections are not included in this dataset. The reconstructed slice data from the scan are offered here as a series of unsigned 16-bit integer TIFF images. The upper left corner of the first image (*_0000.tif) is the XYZ origin.
- Keyword:
- Paleontology, Fossil, CT, CTEES, UMMP, University of Michigan Museum of Paleontology, Vertebrate, Chondrichthyes, Marshall Sandstone, Mississippian , and Carboniferous
- Citation to related publication:
- JAMES V. ANDREWS, ETHAN A. SHIRLEY, AND RODRIGO T. FIGUEROA. VERTEBRATES OF THE BLUE RIDGE ESKER (MISSISSIPPIAN, MARSHALL SANDSTONE) OF MICHIGAN. Contributions from the Museum of Paleontology, University of Michigan, Vol. 36, no. 3, pp. 1–16, 2024
- Discipline:
- Science
-
- Creator:
- University of Michigan Museum of Paleontology and CTEES
- Description:
- Reconstructed CT slices for Slabs of Vertebrate (University of Michigan Museum of Paleontology catalog number UMMP VP 119345) as a series of TIFF images. Raw projections are not included in this dataset. The reconstructed slice data from the scan are offered here as a series of unsigned 16-bit integer TIFF images. The upper left corner of the first image (*_0000.tif) is the XYZ origin.
- Keyword:
- Paleontology, Fossil, CT, CTEES, UMMP, University of Michigan Museum of Paleontology , Vertebrate, Chondrichthyes, Marshall Sandstone, Mississippian, and Carboniferous
- Citation to related publication:
- JAMES V. ANDREWS, ETHAN A. SHIRLEY, AND RODRIGO T. FIGUEROA. VERTEBRATES OF THE BLUE RIDGE ESKER (MISSISSIPPIAN, MARSHALL SANDSTONE) OF MICHIGAN. Contributions from the Museum of Paleontology, University of Michigan, Vol. 36, no. 3, pp. 1–16, 2024
- Discipline:
- Science