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- Creator:
- Patil, Crystal
- Description:
- We conducted a hybrid effectiveness-implementation trial at seven clinics in Blantyre District, Malawi, comparing outcomes for 1887 pregnant women randomly assigned to Group ANC or Individual ANC. The seven study clinics were selected in consultation with the Blantyre District health team to represent a diversity of clinics and communities served. The catchment areas and populations served by the clinics differ socioeconomically. Three clinics serve the urban population of Blantyre city, the rapidly-growing second largest city in Malawi. Two clinics serve the peri-urban communities adjacent to metropolitan Blantyre, and two clinics primarily serve a rural and predominately agricultural community. The clinics varied in volume and number of working midwives. , To be eligible to participate in this study, participants had to be pregnant, over the age of 14, have a gestational age of less than 24 weeks, and be capable of making an informed choice about participation. Those aged 15-17 assented with consent from a legal guardian. Those who did not meet all criteria were excluded. All pregnant women presenting for their first antenatal visit received the same standard individual intake visit that included a health assessment with the midwife, laboratory tests, and HIV testing. , and After completing the intake visit, midwives directed clients to study team members so that eligibility could be assessed. Interested women then learned the information needed to give informed consent and sign a consent form. They then completed the baseline self-report survey using Audio Computer-Assisted Self-Interview software. The study statistician determined the randomization order list for each site before recruitment, and assignments were placed in order in sealed envelopes. After completing the baseline survey, the woman selected the next sealed envelope in that clinic’s box to reveal the type of ANC assignment, Group ANC or Individual ANC. Seven individual-level demographic and socioeconomic variables were treated as covariates in all analyses. Two clinic-level variables were also included as covariates, catchment area (rural, peri-urban, or urban) and midwife ANC workloads. Midwife ANC workloads were captured by a ratio of the average number of new ANC clients served each month divided by the number of midwives, with a higher ratio indicating a higher workload. The ratio was highest in two rural-serving clinics and substantially lower in peri-urban and urban communities.
- Keyword:
- Group antenatal care, Malawi, pregnancy, and woman-centered
- Citation to related publication:
- Group antenatal care positively transforms the care experience: Results of an effectiveness trial in Malawi Crystal L. Patil, Kathleen F. Norr, Esnath Kapito, Li C. Liu, Xiaohan Mei, Elizabeth T. Abrams, Elizabeth Chodzaza, Genesis Chorwe-Sungani, Ursula Kafulafula, Allissa Desloge, Ashley Gresh, Rohan D. Jeremiah, Dhruvi R. Patel, Anne Batchelder, Heidy Wang, Jocelyn Faydenko, Sharon S. Rising, Ellen Chirwa medRxiv 2024.12.25.24319635; doi: https://doi.org/10.1101/2024.12.25.24319635
- Discipline:
- Health Sciences
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- Creator:
- Hames, Alexandra, Tipirneni, Renuka, Switzer, Galen, Ayanian, John, Kullgren, Jeffrey, Solway, Erica, and Roberts, Eric
- Description:
- We examined whether enrollment in MA was associated with narrower racial and ethnic disparities in cost-related medical care barriers and cost-related dental care barriers as well as receipt of eye exams among near-poor Medicare beneficiaries. We further examined the extent to which racial and ethnic disparities were narrower among MA enrollees than TM enrollees who did and did not have private supplemental insurance. and This deposit includes code to process data for transparency and reproducibility purposes.
- Citation to related publication:
- Hames AG, Tipirneni R, Switzer GE, Ayanian JZ, Kullgren JT, Solway E, Roberts ET. Racial/Ethnic Disparities in Cost-Related Barriers to Care Among Near-Poor Beneficiaries in Medicare Advantage vs Traditional Medicare. Am J Manag Care. 2024;30(10):e297-e304. doi:10.37765/ajmc.2024.89622
- Discipline:
- Health Sciences
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- Creator:
- Diaz-Espinosa, Jennifer, Stringer, Kathleen, and Rosania, Gus
- Description:
- These data were produced from a study that assessed mitochondrial metabolic function by measuring two metabolites, l-carnitine and acetylcarnitine, to determine their effectiveness as candidate clinical biomarkers for age-related, drug-induced alterations in mitochondrial metabolism. To study age and medication-related changes in mitochondrial metabolism, we administered the FDA-approved mitochondriotropic drug, clofazimine (CFZ), or vehicle for to young and old mice. These findings are described in our manuscript: Clofazimine-Mediated, Age-Related Changes in Skeletal Muscle Mitochondrial Metabolites. Data reported was supported by funding from the National Institute of General Medical Sciences (NIGMS) at the National Institutes of Health (NIH) under award numbers R01GM127787 (GRR), R35GM136312 (KAS), P30AR069620 (K Jepsen), and T32GM140223 (L Isom).
- Keyword:
- adverse drug reactions, mitochondrial metabolism, l-carnitine, acetylcarnitine, and cardiac muscle
- Citation to related publication:
- Diaz-Espinosa J, Stringer KA, Rosania GR. Clofazimine-Mediated, Age-Related Changes in Skeletal Muscle Mitochondrial Metabolites. Metabolites. 2023 May 19;13(5):671. doi: 10.3390/metabo13050671. PMID: 37233713; PMCID: PMC10220805.
- Discipline:
- Health Sciences
-
- Creator:
- Stringer, Kathleen A.
- Description:
- These data were produced from the survival analysis of the pre-treatment metabolomics data generated from the Phase II clinical trial of L-carnitine treatment for septic shock (the RACE trial - see https://clinicaltrials.gov/ct2/show/NCT01665092). The results based on respective acetylcarnitine or valine concentration are presented (pdf). The csv files contain the at risk numbers from the Kaplan-Meier survival analysis. These findings described in our manuscript: Pharmacometabolomics Identifies Candidate Predictor Metabolites of an L-carnitine Treatment Mortality Benefit in Septic Shock. and All of the metabolomics data are available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org which is supported by NIH grant U2C-DK119886 and where it has been assigned Project ID (accession number ST001319). The data can be accessed directly via its Project DOIs: (DOI: http://dx.doi.org/10.21228/M8VX0Z).
- Keyword:
- sepsis, septic shock, survival, mortality, metabolomics, and pharmacometabolomics
- Citation to related publication:
- Puskarich, M. A., Jennaro, T. S., Gillies, C. E., Evans, C. R., Karnovsky, A., McHugh, C. E., Flott, T. L., Jones, A. E., Stringer, K. A., & Investigators, O. behalf of the R. T. (2021). Pharmacometabolomics Identifies Candidate Predictor Metabolites of an L-carnitine Treatment Mortality Benefit in Septic Shock. (Preprint) https://doi.org/10.1101/2021.01.28.21250687 and Puskarich MA, Jennaro TS, Gillies CE, et al; the RACE Trial Investigators. Pharmacometabolomics identifies candidate predictor metabolites of an L-carnitine treatment mortality benefit in septic shock. Clin Transl Sci. 2021; 14: 2288–2299. https://doi.org/10.1111/cts.13088
- Discipline:
- Health Sciences
-
- Creator:
- Lester, Corey A, Al Kontar, Raed, and Chen, Qiyuan
- Description:
- The dataset contains images of pills inside a medication bottle from a top down view. The dataset was used to build an image classification model for predicting the national drug code (NDC) of the medication seen in the image. There are 13,955 images of 20 distinct NDC. The image data were used to create a machine learning algorithm which could predict the NDC.
- Keyword:
- Medication, Pills, and Image
- Citation to related publication:
- Lester, C.A., Li, J., Ding, Y. et al. Performance evaluation of a prescription medication image classification model: an observational cohort. npj Digit. Med. 4, 118 (2021). https://doi.org/10.1038/s41746-021-00483-8
- Discipline:
- Health Sciences
-
- Creator:
- Roberts, Eric, Ruggiero, Dominic, Stefanesu, Andrei, Patel, Syama, Hames, Alexandra, and Tipirneni, Renu
- Description:
- We analyzed satisfaction with care, out-of-pocket costs, and specialist access among community-dwelling Medicare Current Beneficiary Survey respondents, 2015–2019, in the 50 states and Washington, DC. For each measure, we constructed a binary indicator indicating very satisfied (vs. very dissatisfied to satisfied)., We used logistic regression to model outcomes as a function of Medicare Advantage - MA (vs. Traditional Medicare - TM) enrollment, respondent-reported race/ethnicity, and interactions of MA with race/ethnicity. Race/ethnicity was categorized as non-Hispanic Black, Hispanic, and non-Hispanic White. We adjusted for age, sex, education, income, tobacco use, chronic conditions, functional limitations, disability, and geographic factors. Racial/ethnic disparities reflect effects of structural factors that systematically disadvantage members of minoritized racial/ethnic groups. Because structural racism contributes to disparities in socioeconomic status (including income and education), we verified that our estimates did not change appreciably when we did not adjust for socioeconomic factors. , and Analyses were weighted by a composite of survey weights and propensity score weights to balance MA and TM populations within racial/ethnic groups. Separate analyses were conducted for beneficiaries with vs. without dual eligibility for full Medicaid. We used SAS to process the data.
- Keyword:
- Medicare, Access, Affordability, and Racial Disparities
- Citation to related publication:
- Roberts ET, Ruggiero DA, Stefanesu A, Patel S, Hames AG, Tipirneni R. Racial and Ethnic Disparities in Satisfaction with Healthcare Access and Affordability in Medicare Advantage vs. Traditional Medicare. Journal of general internal medicine. 2024 September;39(12):2368-2371. PubMed PMID: 38926325; PubMed Central PMCID: PMC11347532; DOI: 10.1007/s11606-024- 08892-7.
- Discipline:
- Health Sciences
-
- Creator:
- Dou, John F, Thangaraj, Soundara Viveka , Zhou, Yiran , Padmanabhan, Vasantha , and Bakulski, Kelly M
- Description:
- This dataset contains full results tables for differentially methylated region analysis in the paper "Developmental Programming: Differing impact of prenatal testosterone and prenatal bisphenol-A -treatment on hepatic methylome in female sheep". Each table contains the following columns: chromosome (chr), start genomic position of region (start), end genomic position of region (end), width of region (width), number of CpGs in region (nCpG), test statistic (stat), p-value (pval), FDR corrected p-value (qval), gene located within or overlapping region (gene), mean difference between comparison groups (meanDiff). Supplemental Table 1: Differentially methylated regions associated with prenatal-Testosterone treatment in sheep liver Supplemental Table 3: Differentially methylated regions associated with prenatal-BPA treatment in sheep liver Supplemental Table 6: Differentially methylated regions in Controls between the prenatal-Testosterone and prenatal-BPA treated sheep.
- Keyword:
- BPA, testosterone, prenatal, liver, and DNA methylation
- Citation to related publication:
- Dou J, Thangaraj, SV, Zhou Y , Padmanabhan V, Bakulski, KM. Developmental Programming: Differing impact of prenatal testosterone and prenatal bisphenol-A -treatment on hepatic methylome in female sheep. Forthcoming.
- Discipline:
- Health Sciences
-
- Creator:
- Jalin, Aditya MI, Swatthong, Nawat MI, Rozwadowski, Michelle MI, Kumar, Rajnish MI, Braun, Tom MI, Carlozzi, Noelle MI, Hanauer, David MI, Hassett, Afton MI, Tewari, Muneesh MI, and Choi, Sung MI
- Description:
- Research Overview: This dataset captures the longitudinal experience of both patients undergoing hematopoietic cell transplantation (HCT) and their caregivers through continuous physiological monitoring, daily mood reporting, and periodic health assessments. The data provides unprecedented insight into the dynamic relationship between caregiver well-being and patient outcomes during the critical post-transplant period. and Key Points: Digital biomarker data collected from 166 HCT caregiver-patient dyads over 120 days post-transplant Comprehensive physiological monitoring through wearable devices (Fitbit® Charge 3) Integration of daily mood reports, PROMIS® health measures, and clinical outcomes Unique paired data structure allowing analysis of caregiver-patient dynamics
- Keyword:
- Hematopoietic Stem Cell Transplantation, Caregiver-patient dyads, Physiological monitoring, Wearable Devices, Digital Biomarkers, and Health-related Quality of Life
- Citation to related publication:
- Jalin A, Swatthong N, Rozwadowski M, Kumar R, Barton D, Braun T, Carlozzi N, Hanauer DA, Hassett A, Choi SW. A Digital Biomarker Dataset in Hematopoietic Cell Transplantation: A Longitudinal Study of Caregiver-Patient Dyads (dHCT). medRxiv [Preprint]. 2024 Nov 22:2024.11.21.24317641. doi: 10.1101/2024.11.21.24317641. PMID: 39606379; PMCID: PMC11601742. and Rozwadowski M, Dittakavi M, Mazzoli A, Hassett AL, Braun T, Barton DL, Carlozzi N, Sen S, Tewari M, Hanauer DA, Choi SW. Promoting Health and Well-Being Through Mobile Health Technology (Roadmap 2.0) in Family Caregivers and Patients Undergoing Hematopoietic Stem Cell Transplantation: Protocol for the Development of a Mobile Randomized Controlled Trial. JMIR Res Protoc. 2020 Sep 18;9(9):e19288. doi: 10.2196/19288. PMID: 32945777; PMCID: PMC7532463.
- Discipline:
- Health Sciences
-
- Creator:
- Frydendall, Elyse K and Scott, Emily E
- Description:
- This table contains the names, molecular mass (g/mol), and SMILES structure for all compounds tested for CYP2W1 inhibition in the high throughput screen described in this chapter in the tab titled “Compound Library”. Compounds that were identified as CYP2W1 inhibitors are listed in the tab titled “CYP2W1 inhibitors.” This tab contains compound names, molecular mass (g/mol), average standard deviation, number of experiments in which a compound was classified as a hit, number of experimental replicates, hit rate, and SMILES structure.
- Keyword:
- cytochrome P450 enzyme and high throughput inhibition assay
- Discipline:
- Health Sciences
-
- Creator:
- Frydendall, Elyse K and Scott, Emily E
- Description:
- The table herein consists of library compound names, vendors, catalog numbers, CAS numbers, molecular weights, PUBCHEM ID, cLogP, rotatable bonds, total polar surface area, IUPAC name, SMILES strings, notes on stability and absorbance limits, as well as Kd and ∆Amax values for CYP2A6, CYP2D6, and CYP8B1.
- Keyword:
- cytochrome P450 enzyme, high throughput screen, and cytochrome P450 ligands
- Citation to related publication:
- Frydendall, E.K. and E. E. Scott (2024). "Development of a high throughput cytochrome P450-ligand binding assay." J Biol Chem: 107799.
- Discipline:
- Health Sciences