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- Creator:
- Nunley, Hayden, Nagashima, Mikiko, Martin, Kamirah, Lorenzo Gonzalez, Alcides, Suzuki, Sachihiro C., Norton, Declan A., Wong, Rachel O. L., Raymond, Pamela A., and Lubensky, David K.
- Description:
- This dataset contains images of UV cone nuclei (labelled by transgenic expression of a photoconvertible fluorescent protein) near the retinal margin in live fish. The most important images in the dataset are the following: 1. Images (at 4X magnification) of UV cones immediately after photoconversion of a patch near the retinal margin 2. Images (at 4X magnification) of UV cones 2-4 days after photoconversion of a patch near the retinal margin Also, included is code for calculating triangulations (which connect UV cone nuclei which are nearest neighbors). This code allows us to check for motion of UV cones relative to each other between the time of photoconversion and subsequent imaging.
- Keyword:
- zebrafish cone mosaic, topological defects, tissue patterning, grain boundaries, photoconversion, and defect motion
- Citation to related publication:
- Nunley, H., Nagashima, M., Martin, K., Gonzalez, A. L., Suzuki, S. C., Norton, D. A., Wong, R. O. L., Raymond, P. A., & Lubensky, D. K. (2020). Defect patterns on the curved surface of fish retinae suggest a mechanism of cone mosaic formation. PLOS Computational Biology, 16(12), e1008437. https://doi.org/10.1371/journal.pcbi.1008437 and Hayden Nunley, Mikiko Nagashima, Kamirah Martin, Alcides Lorenzo Gonzalez, Sachihiro C. Suzuki, Declan Norton, Rachel O. L. Wong, Pamela A. Raymond, David K. Lubensky. Defect patterns on the curved surface of fish retinae suggest mechanism of cone mosaic formation. bioRxiv 806679; doi: https://doi.org/10.1101/806679
- Discipline:
- Science
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- Creator:
- Surajit Chatterjee, Adrien Chauvier, Shiba S. Dandpat, Irina Artsimovitch, and Nils G. Walter
- Description:
- These data were generated to study the dynamics of RNAP-ribosome interactions on a nascent mRNA with a preQ1-sensing translational riboswitch in its 5’ untranslated region (UTR). Using single-molecule fluorescence co-localization, we monitored direct transient binding of 30S ribosomal subunit to the individual nascent mRNA molecules in surface-immobilized paused elongation complexes (PECs). Also, using a novel protein-induced fluorescence enhancement assay we monitored the real-time transcription rate of RNA polymerase (RNAP) under different experimental conditions. The DNA template including the preQ1 riboswitch from B. anthracis under the control of the T7A1 promoter was cloned into pUC19 plasmid. Transcription templates for in vitro transcription were generated by PCR.
- Citation to related publication:
- Chatterjee, S., Chauvier, A., Dandpat, S.S., Artsimovitch, I., & Walter, N.G. (2021). A translational riboswitch coordinates nascent transcription-translation coupling. Proc. Natl. Acad. Sci., 118 (16), e2023426118; DOI: 10.1073/pnas.2023426118
- Discipline:
- Science
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- Creator:
- Holmes, Iris A, Monagan Jr., Ivan V, Westphal, Michael F, and Davis Rabosky, Alison R
- Description:
- We generated these data from desert night lizards, Xantusia vigilis, from populations in central California. We performed phylogeographic analyses based on these data.
- Keyword:
- ddRADseq, phylogeography, Xantusia vigilis, lizard, and genome-scale sequencing
- Discipline:
- Science
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- Creator:
- Yang, Emily G, Kort, Eric A, Wu, Dien, Lin, John C, Oda, Tomohiro, Ye, Xinxin, and Lauvaux, Thomas
- Description:
- This data set supports a study that seeks to evaluate global fossil fuel CO2 emissions inventory representations of CO2 emissions of five cities in the Middle East, and assess the ability of satellite observations to inform this evaluation. Improved observational understanding of urban CO2 emissions, a large and dynamic global source of fossil CO2, can provide essential insights for both carbon cycle science and mitigation decision making. In this study we compare three distinct global CO2 emissions inventory representations of urban CO2 emissions for five Middle Eastern cities (Riyadh, Mecca, Tabuk, Jeddah, and Baghdad) and use independent satellite observations from the Orbiting Carbon Observatory-2 (OCO-2) satellite to evaluate the inventory representations of afternoon emissions. We use the column version of the Stochastic Time-Inverted Lagrangian Transport (X-STILT) model to account for atmospheric transport and link emissions to observations. We compare XCO2 simulations with observations to determine optimum inventory scaling factors. Applying these factors, we find that the average summed emissions for all five cities are 100 MtC/y (50-151, 90% CI), which is 2.0 (1.0, 3.0) times the average prior inventory magnitudes. The total adjustment of the emissions of these cities comes out to ~7% (0%, 14%) of total Middle Eastern emissions (~700 MtC/y). We find our results to be insensitive to the prior spatial distributions in inventories of the cities’ emissions, facilitating robust quantitative assessments of urban emission magnitudes without accurate high-resolution gridded inventories. and There are three files included in this data set, and all data are in tab-delimited form. The first file, xco2_lat.zip, contains 26 separate text files, each named by the city and date of the corresponding OCO-2 overpass. Each of these 26 files includes overpass-specific data, with modeled and observed XCO2 values binned by 0.1 degree of latitude. The file overpass_scaling_factors.txt provides the scaling factors for each overpass used in this study. The file city_estimates.txt provides the scaled emissions estimates for each city (or sum of cities) as well as the lower and upper bounds of the 90% confidence intervals, for each inventory.
- Keyword:
- greenhouse gases, carbon dioxide, urban, cities, satellite, remote sensing, Lagrangian modeling, emissions inventories, carbon cycle, and climate
- Citation to related publication:
- Yang, E. G., Kort, E. A., Wu, D., Lin, J. C., Oda, T., Ye, X., & Lauvaux, T. (2020). Using space‐based observations and Lagrangian modeling to evaluate urban carbon dioxide emissions in the Middle East. Journal of Geophysical Research: Atmospheres, 125, e2019JD031922. https://doi.org/10.1029/2019JD031922
- Discipline:
- Science
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- Creator:
- Benjamin Leffel
- Description:
- Data were gathered to test three hypotheses on the impact economic growth has on environmental conditions in urban areas. The three hypotheses are: 1. Income will be associated with reductions in PM2.5, PM10, NO2 and SO2. 2. Public Administration GVA will be associated with reductions in PM2.5, PM10, NO2 and SO2. 3. Urban density will be associated with reductions in PM2.5, PM10, NO2 and SO2. More information about the research and the data can be found in: Benjamin Leffel, Nikki Tavasoli, Brantley Liddle, Kent Henderson & Sabrina Kiernan (2021) Metropolitan air pollution abatement and industrial growth: Global urban panel analysis of PM10, PM2.5, NO2 and SO2, Environmental Sociology, DOI: 10.1080/23251042.2021.1975349.
- Keyword:
- global cities, environment, urban, air pollution, income, Urban Sustainability Research Group, and student-friendly
- Citation to related publication:
- Benjamin Leffel, Nikki Tavasoli, Brantley Liddle, Kent Henderson & Sabrina Kiernan (2021) Metropolitan air pollution abatement and industrial growth: Global urban panel analysis of PM10, PM2.5, NO2 and SO2, Environmental Sociology, DOI: 10.1080/23251042.2021.1975349
- Discipline:
- Social Sciences
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- Creator:
- Lim, Hongki and Dewaraja, Yuni K.
- Description:
- Interest in quantitative imaging of Y-90 is growing because transarterial radioembolization (RE) with Y-90 loaded microspheres is a promising and minimally invasive treatment that is FDA approved for unresectable primary and metastatic liver tumors. These cancers are a leading cause of cancer mortality and morbidity. Radioembolization is a therapy that irradiates liver tumors with radioactive microspheres administered through a microcatheter placed in the hepatic arterial vasculature. Radioembolization is based on the principle that healthy liver and tumor are mainly vascularized by the portal vein and the hepatic artery respectively. As a result, radioactive microspheres are preferentially located in the lesions after they are administered via the hepatic artery.
- Keyword:
- Y-90, PET, SPECT, CT, Segmentation, Organ, Tumor, Label
- Citation to related publication:
- Van, B. J., Dewaraja, Y. K., Sangogo, M. L., & Mikell, J. K. (2021). Y-90 SIRT: Evaluation of TCP variation across dosimetric models. EJNMMI Physics, 8(1), 45. https://doi.org/10.1186/s40658-021-00391-6
- Discipline:
- Health Sciences
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- Creator:
- Roeten, K. J. and Bougher, S. W.
- Description:
- In order to better understand the large-scale impacts of smaller-scale gravity waves in the upper atmosphere of Mars, a modern whole atmosphere, nonlinear, non-orographic, spectral gravity wave parameterization scheme (Yigit et al., 2008) has been added to the ground-to-exosphere 3-D general circulation model, M-GITM (Bougher et al., 2015), which previously did not account for the effects of this physical process. New atmospheric simulations have been run for cases which did and did not utilize this gravity wave parameterization as well as for cases designed to test the sensitivity of certain adjustable parameters within the scheme. After including the gravity wave parameterization scheme into M-GITM, large impacts are found on the simulated mean thermospheric horizontal velocities and temperature structure, especially within the altitude range of 90-170 km (Roeten et al., 2022). The most notable of these impacts include a reduction in speed of the thermospheric easterlies in the summer hemisphere as well as overall cooling, on average, at altitudes above 120 km., Simulations were run for two different seasons at Mars, a solstice (Ls=270) and an equinox (Ls=180). The output from these simulations have been averaged over all local times over a 15-day time period, starting on the day of the solstice or equinox. The output has also been zonally averaged over all longitudes. Files containing these zonally and temporally averaged files are named starting with “MGITM_ZonalAvg”. Both solstice and equinox cases have been simulated once without including the gravity wave parameterization (“nogw”) and once with the gravity wave parameterization included (“withgw”). Additional simulations of the Ls=270 solstice have been done individually adjusting the horizontal wavelength and maximum source flux parameters within the gravity wave scheme. , and Other M-GITM simulations have also been provided in a different format. These M-GITM simulations are ‘flythroughs’ of model output, extracted along the same trajectory path of the MAVEN spacecraft, which allows for better data-model comparisons with in-situ MAVEN/NGIMS (Neutral Gas and Ion Mass Spectrometer) observations. These simulations have been done for three different NGIMS observational campaigns, both for cases that include and do not include the effects of gravity waves. Output from these simulations has NOT been averaged; instead, output from each simulated MAVEN orbit is included within the file. These files are named starting with “MGITM_TempExtraction” or “MGITM_WindExtraction” based on whether the MGITM flythrough was designed to be compared to MAVEN/NGIMS temperature or wind profiles, respectively.
- Keyword:
- Mars, M-GITM, MAVEN, and Mars upper atmosphere
- Citation to related publication:
- Roeten, K. J., Bougher, S. W., Yigit, E., Medvedev, A. S., Benna, M., Elrod, M. K. (2022). Impacts of gravity waves in the Martian thermosphere: The Mars Global Ionosphere- Thermosphere Model coupled with a whole atmosphere gravity wave scheme. Journal of Geophysical Research: Planets. In preparation.
- Discipline:
- Science
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Video data of predation and parasitism by arthropods on small vertebrates in lowland Peruvian Amazon
- Creator:
- Grundler, Michael C, Grundler, Maggie G, and Herrera, V.
- Description:
- Nighttime and diurnal surveys in the lowland Peruvian Amazon of Los Amigos Biological Station were conducted in order to describe herpetological diversity at this site. As a result of these surveys, the predation event between a Pamphobeteus sp. and Marmosops sp. and the myiasis of Ranitomeye uakarii were observed. The video footage was recorded in order to document these interesting interactions between arthropod predators and parasites and vertebrate prey and hosts, and are included for publication in the short communication "Ecological interactions between arthropods and small vertebrates in a lowland Amazon rainforest" in the journal Amphibian and Reptile Conservation.
- Keyword:
- Amazonia, predator-prey, spiders, opposums, frogs, and myiasis
- Citation to related publication:
- von May R, Biggi E, Cárdenas H, Diaz MI, Alarcón C, Herrera V, Santa-Cruz R, Tomasinelli F, Westeen E, Sánchez-Paredes CM, Larson JG, Title PO, Grundler MR, Grundler MC, Davis Rabosky AR, Rabosky DL (2019) Ecological interactions between arthropods and small vertebrates in a lowland Amazon rainforest. Amphibian and Reptile Conservation 13(1): 65–77. http://amphibian-reptile-conservation.org/pdfs/Volume/Vol_13_no_1/ARC_13_1_[General_Section]_65-77_e169_high_res.pdf
- Discipline:
- Science
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- Creator:
- Xiantong Wang
- Description:
- We perform a geomagnetic event simulation using a newly developed magnetohydrodynamic with adaptively embedded particle-in-cell (MHD-AEPIC) model. We have developed effective criteria to identify reconnection sites in the magnetotail and cover them with the PIC model. The MHD-AEPIC simulation results are compared with Hall MHD and ideal MHD simulations to study the impacts of kinetic reconnection at multiple physical scales. At the global scale, the three models produce very similar SYM-H and SuperMag Electrojet (SME) indexes, which indicates that the global magnetic field configurations from the three models are very close to each other. At the mesoscale we compare the simulations with in situ Geotail observations in the tail. All three models produce reasonable agreement with the Geotail observations. The MHD-AEPIC and Hall MHD models produce tailward and earthward propagating fluxropes, while the ideal MHD simulation does not generate flux ropes in the near-earth current sheet. At the kinetic scales, the MHD-AEPIC simulation can produce a crescent shape distribution of the electron velocity space at the electron diffusion region which agrees very well with MMS observations near a tail reconnection site. These electron scale kinetic features are not available in either the Hall MHD or ideal MHD models. Overall, the MHD-AEPIC model compares well with observations at all scales, it works robustly, and the computational cost is acceptable due to the adaptive adjustment of the PIC domain.
- Keyword:
- MHD, PIC, and Magnetosphere
- Discipline:
- Science
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- Creator:
- Gharzai, Laila A, Green, Michael D, Griffith, Kent A, and Jolly, Shruti
- Description:
- Three sensitivity analyses were performed. First, a second matching step was performed in which two controls were selected for each case, where possible using a nearest neighbor and caliper metric. Controls needed to have propensity scores within 0.1 of the case to be selected. Thirty-eight of the 39 cases had at least one control using this method and for 36 cases two controls could be selected. The average difference between case and control propensity adjuvant RT was 0.008 (range 0.00003-0.095). A second sensitivity analysis was performed to guard against immortal time bias. In order to mitigate the possibility of this effect, cases known not to have undergone adjuvant RT have been screened for suitable follow-up without a recurrence (local or regional recurrence, metastatic failure, and/or death) to ensure that if adjuvant RT had been prescribed as part of the multi-modality treatment regimen, that it would have been initiated. Three months was selected as the mandatory follow-up time. One to one matching was carried out and all 39 cases were matched to a control. A third sensitivity analysis was performed to account for stage migration seen in control patients that presented to the University of Michigan with more advanced disease. Patients that underwent adjuvant radiation were matched one to one with control group patients who did not receive adjuvant radiation, and who had the same stage at diagnosis as compared to stage at University of Michigan presentation.
- Keyword:
- adenocortical carcinoma and English
- Citation to related publication:
- Laila A Gharzai, Michael D Green, Kent A Griffith, Tobias Else, Charles S Mayo, Elizabeth Hesseltine, Daniel E Spratt, Edgar Ben-Josef, Aaron Sabolch, Barbara S Miller, Francis Worden, Thomas J Giordano, Gary D Hammer, Shruti Jolly, Adjuvant Radiation Improves Recurrence-Free Survival and Overall Survival in Adrenocortical Carcinoma, The Journal of Clinical Endocrinology & Metabolism, Volume 104, Issue 9, September 2019, Pages 3743–3750, https://doi.org/10.1210/jc.2019-00029
- Discipline:
- Health Sciences