Work Description

Title: Data from: Adjuvant Radiation Improves Recurrence-Free Survival and Overall Survival in Adrenocortical Carcinoma Open Access Deposited

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Methodology
  • This is a retrospective propensity-matched analysis of patients were seen through the University of Michigan’s Endocrine Oncology program, and all those who underwent RT were treated at the University of Michigan. The data for the primary publication are submitted for a separate publication; the data submitted to this repository represents the results of three separate sensitivity analyses for the data.
Description
  • Three sensitivity analyses were performed. First, a second matching step was performed in which two controls were selected for each case, where possible using a nearest neighbor and caliper metric. Controls needed to have propensity scores within 0.1 of the case to be selected. Thirty-eight of the 39 cases had at least one control using this method and for 36 cases two controls could be selected. The average difference between case and control propensity adjuvant RT was 0.008 (range 0.00003-0.095). A second sensitivity analysis was performed to guard against immortal time bias. In order to mitigate the possibility of this effect, cases known not to have undergone adjuvant RT have been screened for suitable follow-up without a recurrence (local or regional recurrence, metastatic failure, and/or death) to ensure that if adjuvant RT had been prescribed as part of the multi-modality treatment regimen, that it would have been initiated. Three months was selected as the mandatory follow-up time. One to one matching was carried out and all 39 cases were matched to a control. A third sensitivity analysis was performed to account for stage migration seen in control patients that presented to the University of Michigan with more advanced disease. Patients that underwent adjuvant radiation were matched one to one with control group patients who did not receive adjuvant radiation, and who had the same stage at diagnosis as compared to stage at University of Michigan presentation.
Creator
Depositor
  • lgharzai@umich.edu
Contact information
Discipline
Keyword
Date coverage
  • 2003-01-01 to 2017-12-30
Resource type
Last modified
  • 01/02/2019
Language
DOI
  • doi:10.7302/wy95-7p22
CC License

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Files (Count: 1; Size: 136 KB)

Thumbnail Title Date Uploaded File Size Access Actions
Ms35t941f?file=thumbnail ACC paper 190102 supplementary data.docx 2019-01-02 136 KB Open Access
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