Search Results

Search Constraints

1 - 2 of 2
Number of results to display per page
View results as:

Search Results

  • Mycoplasma, Bacterial Vaginosis Associated Bacteria BVAB3, Race, and Risk of Preterm Birth in a High Risk Cohort

    3f4625424?file=thumbnail
    Creator:
    Ai Wen, Carl F. Marrs, Betsy Foxman, Deborah Goldberg, Deborah A. Wing, John Owen, Dawn Misra, and Usha Srinivasan
    Description:
    OBJECTIVE—Genital tract infection accounts for ~ 25–40% of all pre-term births. We sought to assess the relationship between preterm birth and selected vaginal bacterial taxa associated with preterm birth either directly or through their association with bacterial vaginosis (BV). STUDY DESIGN—Vaginal fluid for Gram stain was collected between 17 and 22 weeks gestation as part of a randomized trial of ultrasound-indicated cerclage for preterm birth prevention in women at high risk for recurrent spontaneous preterm birth. Bacterial DNA was extracted from the Gram stain slides and analyzed using quantitative PCR. RESULTS—Among the 499 participants, Mycoplasma was positively correlated with increased risk of preterm (RR = 1.83; 95% CI: 1.52,2.22) as was Mobiluncus (RR=1.36; 95% CI: 1.07, 1.73) and Atopobium (RR=1.44; 95% CI: 1.1, 1.87). However, there were strong interactions between race/ethnic group and the presence of these and other individual taxa on risk of preterm birth. By contrast, BVAB3 was consistently associated with a reduction in risk of preterm birth for all racial/ethnic groups (0.55; 95%CI: 0.39, 0.78). CONCLUSIONS—BV is characterized by a reduction of Lactobacillus, and lactic acid producing bacteria and the presence of Mobiluncus; we found these factors and presence of Mycoplasma to be associated with increased risk of preterm birth. By contrast, the presence of a recently identified organism sufficient to cause BV, BVAB3, decreased risk of preterm birth. These findings give insight into why treating BV has mixed impact on risk of preterm birth.
    Citation to related publication:
    Title:
    Mycoplasma, Bacterial Vaginosis Associated Bacteria BVAB3, Race, and Risk of Preterm Birth in a High Risk Cohort

  • Selected Vaginal Bacteria and Risk of Preterm Birth: An Ecological Perspective

    K643b117x?file=thumbnail
    Creator:
    Ai Wen, Carl F. Marrs, Usha Srinivasan, Arianna Miles-Jay, Deborah Goldberg, Deborah A. Wing, Brigette Bucholz, John Owen, Dawn Misra, Betsy Foxman, Sreelatha Ponnaluri, and Kadija Abbas
    Description:
    We examined the community ecology of vaginal microbial samples taken from pregnant women with previous preterm birth experience to investigate whether targeted pathogenic and commensal bacteria are related to risk of preterm birth in the current pregnancy. We found a significant correlation between the community structure of selected bacteria and birth outcome, but the correlation differed among self-reported racial/ethnic groups. Using a community ordination analysis, we observed infrequent co-occurrence of Mycoplasma and bacteria vaginosis associated bacteria 3 (BVAB3) among black and Hispanic participants. In addition, we found that the vaginal bacteria responded differently in different racial/ethnic groups to modifications of maternal behavioral (ie, douching and smoking) and biological traits (ie, body mass index [BMI]). Even after accounting for these maternal behaviors and traits, the selected vaginal bacteria was significantly associated with preterm birth among black and Hispanic participants. By contrast, white participants did not exhibit significant correlation between microbial community and birth outcome. Findings from this study affirm the necessity of considering women’s race/ethnicity when evaluating the correlation between vaginal bacteria and preterm birth. The study also illustrates the importance of studying the vaginal microbiota from an ecological perspective, and demonstrates the power of ecological community analysis to improve understanding of infectious disease.
    Citation to related publication:
    Title:
    Selected Vaginal Bacteria and Risk of Preterm Birth: An Ecological Perspective