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Filtering by: Creator Holcombe, Sven A. Discipline Health Sciences

Dataset for: Relative muscle indices and healthy reference values for sarcopenia assessment using T10 through L5 computed tomography skeletal muscle area

Creator:

Derstine, Brian A., Holcombe, Sven A., Ross, Brian E., Sullivan, June A., Wang, Stewart C., and Su, Grace L.

Description:

Sarcopenia is the age-related loss of skeletal muscle mass and function. Computed tomography (CT) assessments of sarcopenia utilize measurements of skeletal muscle cross-sectional area (SMA), radiation attenuation (SMRA), intramuscular adipose tissue (IMAT), and skeletal muscle gauge (SMG). Unadjusted SMA is strongly correlated with both height and body mass index (BMI); therefore, SMA must be adjusted for body size to assess sarcopenic low muscle mass fairly in individuals of different heights and BMI. SMA/height (rather than SMA/height^2) provides optimal height adjustment for skeletal muscle index (SMI), and vertebra-specific relative muscle index (RMI) equations optimally adjust for both height and BMI. Since L3 measurement is not available in all CT scans, sarcopenic low muscle mass may be assessed using other levels. Both a mid-vertebral slice and an inferior slice have been used to define `L3 SMA', but the effect of vertebral slice location on SMA measurements is unexplored. Healthy reference values for skeletal muscle measures at mid- and inferior vertebra slices between T10 and L5, have not yet been reported.

Keyword:

sarcopenia, skeletal muscle, reference population, Morphomics, Analytic Morphomics, and body composition

Citation to related publication:

Derstine, B.A., Holcombe, S.A., Wang, N.C. et al. Relative muscle indices and healthy reference values for sarcopenia assessment using T10 through L5 computed tomography skeletal muscle area. Scientific Reports 14, 21799 (2024). https://doi.org/10.1038/s41598-024-71613-x

Discipline:

Health Sciences

Dataset for: Relative muscle indices and healthy reference values for sarcopenia assessment using T10 through L5 computed tomography skeletal muscle area

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Dataset for: Relative muscle indices and healthy reference values for sarcopenia assessment using T10 through L5 computed tomography skeletal muscle area

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