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Dataset Associated with "Thermodynamics and Selection of the Plasminogen Activator Inhibitor-1 Latency Transition"

Creator:

Haynes, Laura M, Holding, Matthew L, Woodard, Jaie, Siemieniak, David, and Ginsburg, David

Description:

A phage displayed amino acid site-saturated variant library of plasminogen activator inhibitor (PAI-1) was screened for thermodynamic functional stability. The data are interpreted in the context of protein evolution and computational variant effect/protein stability predictors. This data set contains FASTQ files of the PAI-1 sequence variants that affect its thermodynamic stability, as well as scripts needed to analyze these files.

Keyword:

serpins, deep mutational scanning, thermodynamics, metastable proteins, and purifying selection

Citation to related publication:

Haynes LM, Holding ML,Woodard J, Siemieniak D, Ginsburg D. Thermodynamics and selection of the plasminogen activator inhibitor-1 latency transition. bioRxiv [Preprint]. 2025.06.03.655624; doi: https://doi.org/10.1101/2025.06.03.655624

Discipline:

Science
Dataset for high-throughput amino acid-level characterization of the interactions of plasminogen activator inhibitor-1 with variably divergent proteases

Creator:

Haynes, Laura M, Holding, Matthew L, DiGiovanni, Hannah L, Siemieniak, David, and Ginsburg, David

Description:

This data set contains FASTQ files of PAI-1 sequence variants that differentially inhibit different target proteases. The software needed to analyze these files can be found at https://github.com/hayneslm/PAI-1_and_divergent_proteases.

Keyword:

serpins, serine proteases, coevolution, deep mutational scanning, fibrinolysis, phage display, protein-protein interactions, sequence space, DNA sequencing

Citation to related publication:

Haynes LM, Holding ML, DiGiovanni H, Siemieniak D, Ginsburg D. High-throughput amino acid-level characterization of the interactions of plasminogen activator inhibitor-1 with variably divergent proteases. bioRxiv [Preprint]. 2024 Sep 20:2024.09.16.612699. doi: 10.1101/2024.09.16.612699. PMID: 39345533; PMCID: PMC11429915.

Discipline:

Science

Dataset Associated with "Thermodynamics and Selection of the Plasminogen Activator Inhibitor-1 Latency Transition"

Dataset for high-throughput amino acid-level characterization of the interactions of plasminogen activator inhibitor-1 with variably divergent proteases

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Dataset Associated with "Thermodynamics and Selection of the Plasminogen Activator Inhibitor-1 Latency Transition"

Dataset for high-throughput amino acid-level characterization of the interactions of plasminogen activator inhibitor-1 with variably divergent proteases

Limit your search

Resource type

Creator

Discipline

Language