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Targeted metabolomics analysis of wildtype and interferon alpha/beta receptor 1-deficient murine bone marrow-derived macrophages following methicillin-resistant Staphylococcus aureus infection

Creator:

Reynolds, Mack B, Klein, Benjamin, McFadden, Michael J, Judge, Norah K, Navarrete, Hannah E, Michmerhuizen, Britton C, Awad, Dominik, Schultz, Tracey L, Harms, Paul W, Zhang, Li, O'Meara, Teresa R, Sexton, Jonathan Z, Lyssiotis, Costas A, Kahlenberg, J Michelle, and O'Riordan, Mary X

Description:

Targeted metabolomics analysis of primary WT murine bone marrow-derived macrophages (BMDM) mock-treated or infected with methicillin-resistant Staphylococcus aureus (MRSA) (File S1). Targeted metabolomics analysis of mock-treated or MRSA-infected WT or Ifnar1-/- iBMDM (File S2).

Keyword:

Metabolomics, Macrophage, Staphylococcus aureus, and Interferon

Citation to related publication:

Type I interferon governs immunometabolic checkpoints that coordinate inflammation during Staphylococcal infection Mack B. Reynolds, Benjamin Klein, Michael J. McFadden, Norah K. Judge, Hannah E. Navarrete, Britton C Michmerhuizen, Dominik Awad, Tracey L. Schultz, Paul W. Harms, Li Zhang, Teresa R. O’Meara, Jonathan Z. Sexton, Costas A. Lyssiotis, J. Michelle Kahlenberg, Mary X. O’Riordan bioRxiv 2024.01.10.575104; doi: https://doi.org/10.1101/2024.01.10.575104 and Reynolds et al., Type I Interferon governs immunometabolic checkpoints that coordinate inflammation during Staphylococcal infection, Cell Reports (2024), https://doi.org/10.1016/j.celrep.2024.114607

Discipline:

Science

Targeted metabolomics analysis of wildtype and interferon alpha/beta receptor 1-deficient murine bone marrow-derived macrophages following methicillin-resistant Staphylococcus aureus infection

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Targeted metabolomics analysis of wildtype and interferon alpha/beta receptor 1-deficient murine bone marrow-derived macrophages following methicillin-resistant Staphylococcus aureus infection

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