The focus of this research effort is to systematically study the capability of aging diagnostics using cell expansion under variety of aging conditions and states. The data collection campaign is very important to cover various degradation modes to extract the degradation features that will be used to inform, parameterize, and validate the models developed earlier. In the data collection campaign, we are documenting the evolution of the electrical and mechanical characteristics and especially the reversible mechanical measurement. It is important to note that we collect data using newly developed fixtures that enables the simultaneous measurement of mechanical and electrical response under pseudo-constant pressure.
Magnetic resonance angiography (MRA) of the aorta of a 30 yo healthy volunteer, segmented and discretized using the software CRIMSON ( www.crimson.software).
Additionally, models corresponding to virtually-aged aortic geometries at ages: 40, 60, and 75.
Cuomo F, Roccabianca S, Dillon-Murphy D, Xiao N, Humphrey JD, Figueroa CA (2017) Effects of age-associated regional changes in aortic stiffness on human hemodynamics revealed by computational modeling. PLoS ONE 12(3): e0173177. https://doi.org/10.1371/journal.pone.0173177