Beta cells with knockdown (or KO) of Sec61A2.
Mouse, rat, human cell types.
Also knockdown in mouse islets or dispersed mouse islet cells.
Most experiments analyzed by Western blotting of proinsulin (and other).
Xiaoxi Xu, Thomas W. Bell, Truc Le, Ivy Zhao, Emily Walker, Yiqing Wang, Ning Xu, Scott A. Soleimanpour, Holger A. Russ, Ling Qi, Billy Tsai, Ming Liu*, Peter Arvan*: Role of Sec61α2 translocon in insulin biosynthesis. Diabetes, 2024 Sep 26:db240115. Online ahead of print.
