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Filtering by: Keyword TNAP tissue nonspecific alkaline phosphatase Language English Resource type Dataset

FGFR2-C342Y/+ and FGFR2+/+ Treated with/without Tissue Nonspecific Alkaline Phosphatase (TNAP) Mouse Skulls: C57B:6 strain 3 weeks postnatal

Creator:

Hatch, Nan E.

Description:

Crouzon FGFR2-C342Y/+ and wild type littermate pups on a C57BL/6 congenic background were injected with lentivirus expressing recombinant TNAP enzyme or phosphate buffered saline shortly after birth. Mice were euthanized 3 weeks after birth for analyses.

Keyword:

craniofacial, bone, craniosynotosis, FGFR2, TNAP tissue nonspecific alkaline phosphatase, mouse model, and development

Citation to related publication:

Nam, H. K., Vesela, I., Schutte, S. D., & Hatch, N. E. (2020). Viral delivery of tissue nonspecific alkaline phosphatase diminishes craniosynostosis in one of two FGFR2C342Y/+ mouse models of Crouzon syndrome. PLOS ONE, 15(5), e0234073. https://doi.org/10.1371/journal.pone.0234073

Discipline:

Health Sciences