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Filtering by: Keyword adverse drug reactions Discipline Health Sciences

Clofazimine-Mediated, Age-Related Changes in Skeletal Muscle Mitochondrial Metabolites

Creator:

Diaz-Espinosa, Jennifer, Stringer, Kathleen, and Rosania, Gus

Description:

These data were produced from a study that assessed mitochondrial metabolic function by measuring two metabolites, l-carnitine and acetylcarnitine, to determine their effectiveness as candidate clinical biomarkers for age-related, drug-induced alterations in mitochondrial metabolism. To study age and medication-related changes in mitochondrial metabolism, we administered the FDA-approved mitochondriotropic drug, clofazimine (CFZ), or vehicle for to young and old mice. These findings are described in our manuscript: Clofazimine-Mediated, Age-Related Changes in Skeletal Muscle Mitochondrial Metabolites. Data reported was supported by funding from the National Institute of General Medical Sciences (NIGMS) at the National Institutes of Health (NIH) under award numbers R01GM127787 (GRR), R35GM136312 (KAS), P30AR069620 (K Jepsen), and T32GM140223 (L Isom).

Keyword:

adverse drug reactions, mitochondrial metabolism, l-carnitine, acetylcarnitine, and cardiac muscle

Citation to related publication:

Diaz-Espinosa J, Stringer KA, Rosania GR. Clofazimine-Mediated, Age-Related Changes in Skeletal Muscle Mitochondrial Metabolites. Metabolites. 2023 May 19;13(5):671. doi: 10.3390/metabo13050671. PMID: 37233713; PMCID: PMC10220805.

Discipline:

Health Sciences
Database Screening as a Strategy to Identify Endogenous Candidate Metabolites to Probe and Assess Mitochondrial Drug Toxicity

Creator:

George De la Rosa, Mery Vet, Patel, Dipali, McCann, Marc R., Stringer, Kathleen A., and Rosania, Gus R.

Description:

These data were produced from a study that employed a database strategy to identify candidate mitochondrial metabolites that could be clinically useful to identify individuals at increased risk of mitochondrial-related ADRs. The main candidate metabolite identified by the database strategy was evaluated using a mouse model of mitochondrial drug toxicity. These findings are described in our manuscript: Database Screening as a Strategy to Identify Endogenous Candidate Metabolites to Probe and Assess Mitochondrial Drug Toxicity. Data reported was supported by funding from the National Institute of General Medical Sciences (NIGMS) at the National Institutes of Health (NIH) under award numbers R01GM127787 (GRR) & R35GM136312 (KAS).

Keyword:

mitochondrial-realted metabolites, adverse drug reactions, and mitochondrial drug toxicity

Discipline:

Health Sciences

Clofazimine-Mediated, Age-Related Changes in Skeletal Muscle Mitochondrial Metabolites

Database Screening as a Strategy to Identify Endogenous Candidate Metabolites to Probe and Assess Mitochondrial Drug Toxicity

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Clofazimine-Mediated, Age-Related Changes in Skeletal Muscle Mitochondrial Metabolites

Database Screening as a Strategy to Identify Endogenous Candidate Metabolites to Probe and Assess Mitochondrial Drug Toxicity

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