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  • Middle Huron River Dataset

    work
    Creator:
    Lehman John T
    Description:
    Data were collected while developing a management plan for eliminating nuisance algal blooms in a chain of reservoirs along the Huron River in southeastern Michigan. Federal funding was provided by both the U.S. EPA and the USDA. The river-reservoir system is used for municipal drinking water, wastewater disposal, irrigation, industrial processes, hydroelectric generation, sport fishing, and recreation. The impoundments episodically developed surface scums of cyanobacteria, contained microcystin toxins, and emitted foul odors including hydrogen sulfide. Past management strategy had focused on external phosphorus loading but failed to prevent nuisance conditions. Data collection and analysis pointed to the overwhelming role of internal nutrient loading and resulted in a series of whole lake experiments that destratified Ford Lake during summer and eliminated the nuisance conditions.
    Keyword:
    Eutrophication, Limnology, and Nuisance Algae
    Citation to related publication:
    Ferris JA, Lehman JT. 2007. Interannual variation in diatom bloom dynamics: roles of hydrology, nutrient limitation, sinking, and whole lake manipulation. Water Res. 41:2551-2562., Ferris JA, Lehman JT. 2008. Nutrient budgets and river impoundments: Interannual variation and implications for detecting future changes. Lake Reserv Manage. 24:273-281., Goldenberg SZ, Lehman JT. 2012. Diatom response to the whole lake manipulation of a eutrophic urban impoundment. Hydrobiologia 691:71-80., Lehman EM, McDonald KE, Lehman JT. 2009. Whole lake selective withdrawal experiment to control harmful cyanobacteria in an urban impoundment. Water Res. 43:1187-1198., Lehman JT, Ferris JA, Platte RA. 2007. Role of hydrology in development of a vernal clear water phase in an urban impoundment. Freshwater Biol. 52:1773-1781., Lehman JT, Bell DW, McDonald KE. 2009. Reduced river phosphorus following implementation of a lawn fertilizer ordinance. Lake Reserv Manage. 25:307-312., Lehman JT. 2011. Nuisance cyanobacteria in an urbanized impoundment: Interacting internal phosphorus loading, nitrogen metabolism, and polymixis. Hydrobiologia 611:277-287., Lehman JT, Bell DW, Doubek JP, McDonald KE. 2011. Reduced additions to river phosphorus for three years following implementation of a lawn fertilizer ordinance. Lake Reserv Manage. 27:390-397. , Lehman JT, Doubek JP, Jackson EW. 2013. Effect of reducing allochthonous P load on alkaline phosphatase activity of phytoplankton in an urbanized watershed, SE Michigan, U.S.A. Lake Reserv Manage. 29:116-125., Lehman JT 2014. Understanding the role of induced mixing for management of nuisance algal blooms in an urbanized reservoir. Lake Reserv Manage. 30:1-9., and McDonald KE, Lehman JT. 2013. Dynamics of Aphanizomenon and Microcystis (cyanobacteria) during experimental manipulation of an urban impoundment. Lake Reserv Manage. 29:103-115.
    Discipline:
    Science

  • Prenatal androgen exposure alters the developmental trajectory of both GnRH neuron and preoptic area RNA transcripts in female mice.

    work
    Creator:
    Burger, Laura L , Wagenmaker, Elizabeth R., Phumsatitpong, Chayarndorn , Olson, David P., and Moenter, Suzanne M.
    Description:
    Polycystic ovary syndrome (PCOS) is the most common form of infertility in women. The causes of PCOS are not yet understood and both genetics and early-life exposure have been considered as candidates. With regard to the latter, circulating androgens are elevated in mid-late gestation in women with PCOS, potentially exposing offspring to elevated androgens in utero; daughters of women with PCOS are at increased risk for developing this disorder. Consistent with these clinical observations, prenatal androgenization (PNA) of several species recapitulates many phenotypes observed in PCOS. There is increasing evidence that symptoms associated with PCOS, including elevated luteinizing hormone (LH) (and presumably gonadotropin-releasing hormone (GnRH)) pulse frequency emerge during the pubertal transition. We utilized translating ribosomal affinity purification coupled with RNA sequencing to examine GnRH neuron mRNAs from prepubertal (3wk) and adult female control and PNA mice. Prominent in GnRH neurons were transcripts associated with protein synthesis and cellular energetics, in particular oxidative phosphorylation. The GnRH neuron transcript profile was affected more by the transition from prepuberty to adulthood than by PNA treatment, however PNA did change the developmental trajectory of GnRH neurons. This included families of transcripts related to both protein synthesis and oxidative phosphorylation, which were more prevalent in adults than in prepubertal mice but were blunted in PNA adults. These findings suggest that prenatal androgen exposure can program alterations in the translatome of GnRH neurons, providing a mechanism independent of changes in the genetic code for altered expression. These are Microsoft Excel Files
    Keyword:
    GnRH Neuron TRAP Seq
    Citation to related publication:
    Unprocessed RNASeq data is available at Gene Expression Omnibus ( https://www.ncbi.nlm.nih.gov/gds) accession GSE155314.
    Discipline:
    Science