Search Constraints
Filtering by:
Language
English
Remove constraint Language: English
Discipline
Health Sciences
Remove constraint Discipline: Health Sciences
« Previous |
1 - 10 of 114
|
Next »
Number of results to display per page
View results as:
Search Results
-
- Creator:
- Delacroix, Emerson, Austin, Sarah, Bacon, Elizabeth, Rice, John, Hanson, Erika N., Stoffel, Elena Martinez, Roberts, Scott, Ulhmann, Wendy, Griggs, Jennifer J., Koeppe, Erika, and Resnicow, Ken
- Description:
- Participant-reported results from the MiGHT study Baseline Survey, including knowledge, motivators, and barriers for hereditary cancer genetic testing uptake. This is raw dataset is saved in comma separated value (.csv) format.
- Keyword:
- Hereditary Genetic Testing, Genetic Testing, NCCN Guidelines, and Genetic Counseling
- Discipline:
- Social Sciences and Health Sciences
-
- Creator:
- Ludlow, Andrew and Ahn, Alexander
- Description:
- Publicly accessible short-read RNA sequencing (SRS) of clinical exercise studies were extracted from the Gene Expression Omnibus. Oxford Nanopore long-read RNA sequencing (LRS) was performed on mouse gastrocnemius before and following treadmill exercise. Differential gene expression (DGE), differential alternative splicing (DAS), and differential isoform expression (DIE) were analyzed. Gel-based/droplet digital RT-PCR and western blots were performed to validate expression changes of select genes. Both SRS and LRS illustrated significant DGE in skeletal muscle post-exercise, whereby 89 RBPs were significantly up-/down-regulated. rMATS analysis of SRS data revealed that exon-skipping and intron-retaining splicing events were the most common. Swan analysis of LRS data revealed 61 RBPs with significant isoform switching: one of these RBPs, mHnrnpa3, underwent a significant non-coding to protein-coding switch. HnRNP-A3 protein levels validated nearly two-fold increases at 1 hour and 24 hours post-exercise.
- Keyword:
- Alternative splicing and Exercise
- Citation to related publication:
- Impact of Acute Endurance Exercise on Alternative Splicing in Skeletal Muscle. Alexander Ahn, Jeongjin J. Kim, Aaron L. Slusher, Jeffrey Y. Ying, Eric Y. Zhang, Andrew T. Ludlow bioRxiv 2024.11.21.624690; doi: https://doi.org/10.1101/2024.11.21.624690
- Discipline:
- Health Sciences
-
- Creator:
- Patil, Crystal
- Description:
- We conducted a hybrid effectiveness-implementation trial at seven clinics in Blantyre District, Malawi, comparing outcomes for 1887 pregnant women randomly assigned to Group ANC or Individual ANC. The seven study clinics were selected in consultation with the Blantyre District health team to represent a diversity of clinics and communities served. The catchment areas and populations served by the clinics differ socioeconomically. Three clinics serve the urban population of Blantyre city, the rapidly-growing second largest city in Malawi. Two clinics serve the peri-urban communities adjacent to metropolitan Blantyre, and two clinics primarily serve a rural and predominately agricultural community. The clinics varied in volume and number of working midwives. , To be eligible to participate in this study, participants had to be pregnant, over the age of 14, have a gestational age of less than 24 weeks, and be capable of making an informed choice about participation. Those aged 15-17 assented with consent from a legal guardian. Those who did not meet all criteria were excluded. All pregnant women presenting for their first antenatal visit received the same standard individual intake visit that included a health assessment with the midwife, laboratory tests, and HIV testing. , and After completing the intake visit, midwives directed clients to study team members so that eligibility could be assessed. Interested women then learned the information needed to give informed consent and sign a consent form. They then completed the baseline self-report survey using Audio Computer-Assisted Self-Interview software. The study statistician determined the randomization order list for each site before recruitment, and assignments were placed in order in sealed envelopes. After completing the baseline survey, the woman selected the next sealed envelope in that clinic’s box to reveal the type of ANC assignment, Group ANC or Individual ANC. Seven individual-level demographic and socioeconomic variables were treated as covariates in all analyses. Two clinic-level variables were also included as covariates, catchment area (rural, peri-urban, or urban) and midwife ANC workloads. Midwife ANC workloads were captured by a ratio of the average number of new ANC clients served each month divided by the number of midwives, with a higher ratio indicating a higher workload. The ratio was highest in two rural-serving clinics and substantially lower in peri-urban and urban communities.
- Keyword:
- Group antenatal care, Malawi, pregnancy, and woman-centered
- Citation to related publication:
- Group antenatal care positively transforms the care experience: Results of an effectiveness trial in Malawi Crystal L. Patil, Kathleen F. Norr, Esnath Kapito, Li C. Liu, Xiaohan Mei, Elizabeth T. Abrams, Elizabeth Chodzaza, Genesis Chorwe-Sungani, Ursula Kafulafula, Allissa Desloge, Ashley Gresh, Rohan D. Jeremiah, Dhruvi R. Patel, Anne Batchelder, Heidy Wang, Jocelyn Faydenko, Sharon S. Rising, Ellen Chirwa medRxiv 2024.12.25.24319635; doi: https://doi.org/10.1101/2024.12.25.24319635
- Discipline:
- Health Sciences
-
- Creator:
- Stringer, Kathleen A.
- Description:
- These data were produced from the survival analysis of the pre-treatment metabolomics data generated from the Phase II clinical trial of L-carnitine treatment for septic shock (the RACE trial - see https://clinicaltrials.gov/ct2/show/NCT01665092). The results based on respective acetylcarnitine or valine concentration are presented (pdf). The csv files contain the at risk numbers from the Kaplan-Meier survival analysis. These findings described in our manuscript: Pharmacometabolomics Identifies Candidate Predictor Metabolites of an L-carnitine Treatment Mortality Benefit in Septic Shock. and All of the metabolomics data are available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org which is supported by NIH grant U2C-DK119886 and where it has been assigned Project ID (accession number ST001319). The data can be accessed directly via its Project DOIs: (DOI: http://dx.doi.org/10.21228/M8VX0Z).
- Keyword:
- sepsis, septic shock, survival, mortality, metabolomics, and pharmacometabolomics
- Citation to related publication:
- Puskarich, M. A., Jennaro, T. S., Gillies, C. E., Evans, C. R., Karnovsky, A., McHugh, C. E., Flott, T. L., Jones, A. E., Stringer, K. A., & Investigators, O. behalf of the R. T. (2021). Pharmacometabolomics Identifies Candidate Predictor Metabolites of an L-carnitine Treatment Mortality Benefit in Septic Shock. (Preprint) https://doi.org/10.1101/2021.01.28.21250687 and Puskarich MA, Jennaro TS, Gillies CE, et al; the RACE Trial Investigators. Pharmacometabolomics identifies candidate predictor metabolites of an L-carnitine treatment mortality benefit in septic shock. Clin Transl Sci. 2021; 14: 2288–2299. https://doi.org/10.1111/cts.13088
- Discipline:
- Health Sciences
-
- Creator:
- Jalin, Aditya MI, Swatthong, Nawat MI, Rozwadowski, Michelle MI, Kumar, Rajnish MI, Braun, Tom MI, Carlozzi, Noelle MI, Hanauer, David MI, Hassett, Afton MI, Tewari, Muneesh MI, and Choi, Sung MI
- Description:
- Research Overview: This dataset captures the longitudinal experience of both patients undergoing hematopoietic cell transplantation (HCT) and their caregivers through continuous physiological monitoring, daily mood reporting, and periodic health assessments. The data provides unprecedented insight into the dynamic relationship between caregiver well-being and patient outcomes during the critical post-transplant period. and Key Points: Digital biomarker data collected from 166 HCT caregiver-patient dyads over 120 days post-transplant Comprehensive physiological monitoring through wearable devices (Fitbit® Charge 3) Integration of daily mood reports, PROMIS® health measures, and clinical outcomes Unique paired data structure allowing analysis of caregiver-patient dynamics
- Keyword:
- Hematopoietic Stem Cell Transplantation, Caregiver-patient dyads, Physiological monitoring, Wearable Devices, Digital Biomarkers, and Health-related Quality of Life
- Citation to related publication:
- Jalin A, Swatthong N, Rozwadowski M, Kumar R, Barton D, Braun T, Carlozzi N, Hanauer DA, Hassett A, Choi SW. A Digital Biomarker Dataset in Hematopoietic Cell Transplantation: A Longitudinal Study of Caregiver-Patient Dyads (dHCT). medRxiv [Preprint]. 2024 Nov 22:2024.11.21.24317641. doi: 10.1101/2024.11.21.24317641. PMID: 39606379; PMCID: PMC11601742. and Rozwadowski M, Dittakavi M, Mazzoli A, Hassett AL, Braun T, Barton DL, Carlozzi N, Sen S, Tewari M, Hanauer DA, Choi SW. Promoting Health and Well-Being Through Mobile Health Technology (Roadmap 2.0) in Family Caregivers and Patients Undergoing Hematopoietic Stem Cell Transplantation: Protocol for the Development of a Mobile Randomized Controlled Trial. JMIR Res Protoc. 2020 Sep 18;9(9):e19288. doi: 10.2196/19288. PMID: 32945777; PMCID: PMC7532463.
- Discipline:
- Health Sciences
-
- Creator:
- Frydendall, Elyse K and Scott, Emily E
- Description:
- This table contains the names, molecular mass (g/mol), and SMILES structure for all compounds tested for CYP2W1 inhibition in the high throughput screen described in this chapter in the tab titled “Compound Library”. Compounds that were identified as CYP2W1 inhibitors are listed in the tab titled “CYP2W1 inhibitors.” This tab contains compound names, molecular mass (g/mol), average standard deviation, number of experiments in which a compound was classified as a hit, number of experimental replicates, hit rate, and SMILES structure.
- Keyword:
- cytochrome P450 enzyme and high throughput inhibition assay
- Discipline:
- Health Sciences
-
- Creator:
- Frydendall, Elyse K and Scott, Emily E
- Description:
- The table herein consists of library compound names, vendors, catalog numbers, CAS numbers, molecular weights, PUBCHEM ID, cLogP, rotatable bonds, total polar surface area, IUPAC name, SMILES strings, notes on stability and absorbance limits, as well as Kd and ∆Amax values for CYP2A6, CYP2D6, and CYP8B1.
- Keyword:
- cytochrome P450 enzyme, high throughput screen, and cytochrome P450 ligands
- Citation to related publication:
- Frydendall, E.K. and E. E. Scott (2024). "Development of a high throughput cytochrome P450-ligand binding assay." J Biol Chem: 107799.
- Discipline:
- Health Sciences
-
- Creator:
- Frydendall, Elyse K and Scott, Emily E
- Description:
- This table contains the dissociation constants, maximum changes in absorbance, and ratio of dissociation constant to maximum change in absorbance as calculated for compounds from the a library of 104 azoles. Compounds that did not result in a spectral shift are denoted with dashes. Properties of each azole is also included such as CAS, ClogP, number of rotatable bonds, TPSA (Å2), IUPAC name, and SMILES structure.
- Keyword:
- cytochrome P450 enzyme and high throughput binding assay
- Citation to related publication:
- Frydendall, E. K. and E. E. Scott (2024). "Development of a high throughput cytochrome P450-ligand binding assay." J Biol Chem: 107799.
- Discipline:
- Health Sciences
-
- Creator:
- Jean Nemzek and Chris Fry
- Description:
- After an initial acclimation period at standard temperatures, mice were randomly placed in static cages (3-5 mice/cage) in specialized climate chambers (Powerscientific, Pipersville, PA). Chamber temperatures were set to either 22°C or 30°C with relative humidity set to 30%. After 7 days, groups of mice (n=10/group) were euthanized without further manipulations to establish the effects of ambient temperature on select markers of inflammation including cell counts and cytokine concentrations in plasma and peritoneal lavage fluid. Spleen cells were harvested for total counts and in vitro stimulation. Additional groups of mice exposed to either 22°C or 30°C underwent cecal ligation and puncture surgery to induce polymicrobial peritonitis, then returned to their assigned housing temperature. Survival was monitored for 7 days after surgery. In a separate cohort of mice, inflammatory responses at 6 hours after surgery were examined in the systemic (blood) and local (peritoneal lavage) compartments. the experiment was repeated with mice implanted with a thermistor to monitor body temperature over 72 hours.
- Keyword:
- sepsis, ambient temperature, and inflammation
- Citation to related publication:
- Chan G, et al. Impact of thermoneutral acclimation on a murine model of polymicrobial peritonitis. Under review.
- Discipline:
- Health Sciences
-
- Creator:
- Best, T. Kevin, Seelhoff, C. Andrew, Wensman, Jeffrey, and Gregg, Robert D.
- Description:
- The dataset was collected to assess the clinical benefits of the latest generation Össur Power Knee with and without phase-based control compared to traditional passive microprocessor-controlled knees. The study included seven above-knee amputee participants and examined performance across a series of sit/stand and walking experiments. Data captured includes event logs, processed inverse kinematics and dynamics data, scaled OpenSim skeletons for each session, and raw motion capture and force plate data for various test conditions (HKIC, OSSR, PRES). All data is text-based and can be viewed in any compatible text editor. Data can be visualized in OpenSim. The dataset is organized by subject and test condition. Each folder includes a scaled subject OpenSim skeleton (*_skeleton.osim), a marker file for a range of motion trial (*_range_of_motion.trc), and three test folders each containing: Event Logs (*.event_log.csv): Time-stamped records of experimental events. Inverse Kinematics Data (*_IK.mot): Joint angle trajectories. Inverse Dynamics Data (*_ID.mot): Joint moment trajectories. Raw Marker Data (*_markers.csv): 3D coordinates of motion capture markers. Ground Reaction Force Data (*_GRF.mot): Force plate measurements of ground reactions during movement tasks.
- Keyword:
- Robotic Prostheses, Transfemoral Amputees, and Prosthesis Control
- Citation to related publication:
- T. Kevin Best, C. Andrew Seelhoff, Jeffrey Wensman, Robert D. Gregg, "The Össur Power Knee with Phase-Based Control Provides Clinical Benefits over Passive Microprocessor Knees," Submitted to the Journal of NeuroEngineering and Rehabilitation, 2025.
- Discipline:
- Engineering and Health Sciences