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- Creator:
- Jalin, Aditya MI, Swatthong, Nawat MI, Rozwadowski, Michelle MI, Kumar, Rajnish MI, Braun, Tom MI, Carlozzi, Noelle MI, Hanauer, David MI, Hassett, Afton MI, Tewari, Muneesh MI, and Choi, Sung MI
- Description:
- Research Overview: This dataset captures the longitudinal experience of both patients undergoing hematopoietic cell transplantation (HCT) and their caregivers through continuous physiological monitoring, daily mood reporting, and periodic health assessments. The data provides unprecedented insight into the dynamic relationship between caregiver well-being and patient outcomes during the critical post-transplant period. and Key Points: Digital biomarker data collected from 166 HCT caregiver-patient dyads over 120 days post-transplant Comprehensive physiological monitoring through wearable devices (Fitbit® Charge 3) Integration of daily mood reports, PROMIS® health measures, and clinical outcomes Unique paired data structure allowing analysis of caregiver-patient dynamics
- Keyword:
- Hematopoietic Stem Cell Transplantation, Caregiver-patient dyads, Physiological monitoring, Wearable Devices, Digital Biomarkers, and Health-related Quality of Life
- Citation to related publication:
- Jalin A, Swatthong N, Rozwadowski M, Kumar R, Barton D, Braun T, Carlozzi N, Hanauer DA, Hassett A, Choi SW. A Digital Biomarker Dataset in Hematopoietic Cell Transplantation: A Longitudinal Study of Caregiver-Patient Dyads (dHCT). medRxiv [Preprint]. 2024 Nov 22:2024.11.21.24317641. doi: 10.1101/2024.11.21.24317641. PMID: 39606379; PMCID: PMC11601742. and Rozwadowski M, Dittakavi M, Mazzoli A, Hassett AL, Braun T, Barton DL, Carlozzi N, Sen S, Tewari M, Hanauer DA, Choi SW. Promoting Health and Well-Being Through Mobile Health Technology (Roadmap 2.0) in Family Caregivers and Patients Undergoing Hematopoietic Stem Cell Transplantation: Protocol for the Development of a Mobile Randomized Controlled Trial. JMIR Res Protoc. 2020 Sep 18;9(9):e19288. doi: 10.2196/19288. PMID: 32945777; PMCID: PMC7532463.
- Discipline:
- Health Sciences
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- Creator:
- Frydendall, Elyse K and Scott, Emily E
- Description:
- This table contains the names, molecular mass (g/mol), and SMILES structure for all compounds tested for CYP2W1 inhibition in the high throughput screen described in this chapter in the tab titled “Compound Library”. Compounds that were identified as CYP2W1 inhibitors are listed in the tab titled “CYP2W1 inhibitors.” This tab contains compound names, molecular mass (g/mol), average standard deviation, number of experiments in which a compound was classified as a hit, number of experimental replicates, hit rate, and SMILES structure.
- Keyword:
- cytochrome P450 enzyme and high throughput inhibition assay
- Discipline:
- Health Sciences
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- Creator:
- Frydendall, Elyse K and Scott, Emily E
- Description:
- The table herein consists of library compound names, vendors, catalog numbers, CAS numbers, molecular weights, PUBCHEM ID, cLogP, rotatable bonds, total polar surface area, IUPAC name, SMILES strings, notes on stability and absorbance limits, as well as Kd and ∆Amax values for CYP2A6, CYP2D6, and CYP8B1.
- Keyword:
- cytochrome P450 enzyme, high throughput screen, and cytochrome P450 ligands
- Citation to related publication:
- Frydendall, E.K. and E. E. Scott (2024). "Development of a high throughput cytochrome P450-ligand binding assay." J Biol Chem: 107799.
- Discipline:
- Health Sciences
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- Creator:
- Frydendall, Elyse K and Scott, Emily E
- Description:
- This table contains the dissociation constants, maximum changes in absorbance, and ratio of dissociation constant to maximum change in absorbance as calculated for compounds from the a library of 104 azoles. Compounds that did not result in a spectral shift are denoted with dashes. Properties of each azole is also included such as CAS, ClogP, number of rotatable bonds, TPSA (Å2), IUPAC name, and SMILES structure.
- Keyword:
- cytochrome P450 enzyme and high throughput binding assay
- Citation to related publication:
- Frydendall, E. K. and E. E. Scott (2024). "Development of a high throughput cytochrome P450-ligand binding assay." J Biol Chem: 107799.
- Discipline:
- Health Sciences
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- Creator:
- Jean Nemzek and Chris Fry
- Description:
- After an initial acclimation period at standard temperatures, mice were randomly placed in static cages (3-5 mice/cage) in specialized climate chambers (Powerscientific, Pipersville, PA). Chamber temperatures were set to either 22°C or 30°C with relative humidity set to 30%. After 7 days, groups of mice (n=10/group) were euthanized without further manipulations to establish the effects of ambient temperature on select markers of inflammation including cell counts and cytokine concentrations in plasma and peritoneal lavage fluid. Spleen cells were harvested for total counts and in vitro stimulation. Additional groups of mice exposed to either 22°C or 30°C underwent cecal ligation and puncture surgery to induce polymicrobial peritonitis, then returned to their assigned housing temperature. Survival was monitored for 7 days after surgery. In a separate cohort of mice, inflammatory responses at 6 hours after surgery were examined in the systemic (blood) and local (peritoneal lavage) compartments. the experiment was repeated with mice implanted with a thermistor to monitor body temperature over 72 hours.
- Keyword:
- sepsis, ambient temperature, and inflammation
- Citation to related publication:
- Chan G, et al. Impact of thermoneutral acclimation on a murine model of polymicrobial peritonitis. Under review.
- Discipline:
- Health Sciences
-
- Creator:
- Best, T. Kevin, Seelhoff, C. Andrew, Wensman, Jeffrey, and Gregg, Robert D.
- Description:
- The dataset was collected to assess the clinical benefits of the latest generation Össur Power Knee with and without phase-based control compared to traditional passive microprocessor-controlled knees. The study included seven above-knee amputee participants and examined performance across a series of sit/stand and walking experiments. Data captured includes event logs, processed inverse kinematics and dynamics data, scaled OpenSim skeletons for each session, and raw motion capture and force plate data for various test conditions (HKIC, OSSR, PRES). All data is text-based and can be viewed in any compatible text editor. Data can be visualized in OpenSim. The dataset is organized by subject and test condition. Each folder includes a scaled subject OpenSim skeleton (*_skeleton.osim), a marker file for a range of motion trial (*_range_of_motion.trc), and three test folders each containing: Event Logs (*.event_log.csv): Time-stamped records of experimental events. Inverse Kinematics Data (*_IK.mot): Joint angle trajectories. Inverse Dynamics Data (*_ID.mot): Joint moment trajectories. Raw Marker Data (*_markers.csv): 3D coordinates of motion capture markers. Ground Reaction Force Data (*_GRF.mot): Force plate measurements of ground reactions during movement tasks.
- Keyword:
- Robotic Prostheses, Transfemoral Amputees, and Prosthesis Control
- Citation to related publication:
- T. Kevin Best, C. Andrew Seelhoff, Jeffrey Wensman, Robert D. Gregg, "The Össur Power Knee with Phase-Based Control Provides Clinical Benefits over Passive Microprocessor Knees," Submitted to the Journal of NeuroEngineering and Rehabilitation, 2025.
- Discipline:
- Engineering and Health Sciences
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- Creator:
- Morgan, Rachel K, Tapaswi, Anagha, and Colacino, Justin
- Description:
- SH-SY5Y cells were differentiated into neuron-like cells in the presence of continuous and environmentally relevant levels of lead (Pb). Cells were collected every three days (beginning on day 6 of the 18 day protocol) for the purposes of RNA extraction and subsequent sequencing.
- Keyword:
- Neurotoxicology, Chemical Exposure, Benchmark Dose, Transcriptomics
- Citation to related publication:
- Rachel K. Morgan, Anagha Tapaswi, Katelyn M. Polemi, Elizabeth C. Tolrud, Kelly M. Bakulski, Laurie K. Svoboda, Dana C. Dolinoy, Justin A. Colacino bioRxiv 2024.10.29.620844; doi: https://doi.org/10.1101/2024.10.29.620844
- Discipline:
- Health Sciences
-
- Creator:
- Rager, Theresa, Mmeje, Okeoma, and Parker, Jayelin
- Description:
- Our final sample included 445 participants. Most identified as White (65.0%), non-Hispanic (82.8%), and heterosexual (60.0%). The study revealed disparities in comfort levels regarding receiving home-based STI-test kits at home and other household members seeing them; responses varied by education level, gender identity, and U.S. region. Individuals with less than a high school education were less likely to feel comfortable self-collecting for STI testing.
- Keyword:
- sexually transmitted infection
- Citation to related publication:
- Parker JN, Rager TL, Burns J, Mmeje O. Data Verification and Respondent Validity for an Internet-Based Sexual Health Survey: Tutorial. JMIR Form Res. 2024;8. doi:10.2196/56788
- Discipline:
- Health Sciences
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- Creator:
- Arvan, Peter
- Description:
- Beta cells with knockdown (or KO) of Sec61A2. Mouse, rat, human cell types. Also knockdown in mouse islets or dispersed mouse islet cells. Most experiments analyzed by Western blotting of proinsulin (and other).
- Keyword:
- Sec61A2
- Citation to related publication:
- Xiaoxi Xu, Thomas W. Bell, Truc Le, Ivy Zhao, Emily Walker, Yiqing Wang, Ning Xu, Scott A. Soleimanpour, Holger A. Russ, Ling Qi, Billy Tsai, Ming Liu*, Peter Arvan*: Role of Sec61α2 translocon in insulin biosynthesis. Diabetes, 2024 Sep 26:db240115. Online ahead of print.
- Discipline:
- Health Sciences
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- Creator:
- Teague, Seth, Yu, Zhiyuan, and Heemskerk, Idse
- Description:
- Images were collected as part of a project investigating the interpretation of BMP signaling dynamics by differentiating human pluripotent stem cells. Image files are in the proprietary Imaris (.ims) file format. MATLAB and Python code for image processing and quantification is provided with the data and at https://github.com/seth414/HeemskerkLabMethods. Processed data originally published in Teague et al., 2024 (see below).
- Keyword:
- cell tracking, human pluripotent stem cells, immunofluorescence, and signaling dynamics
- Citation to related publication:
- Teague, S., Primavera, G., Chen, B. et al. Time-integrated BMP signaling determines fate in a stem cell model for early human development. Nat Commun 15, 1471 (2024). https://doi.org/10.1038/s41467-024-45719-9
- Discipline:
- Health Sciences and Engineering