Work Description

Title: Transmission of Oral microbiome and Sequencing - Influenza Susceptibility Open Access Deposited
Attribute Value
  • Index cases of influenza were identified at a major healthcare facility in Managua, Nicaragua. Index cases and their family members were enrolled for follow up and with nose/throat samples collected at 2-3 day intervals for up to 13 days. Sociodemographic and household data were collected at enrollment. 16S rRNA sequencing (V4, Illumina MiSeq) was conducted on samples collected at enrollment and at the last day of follow up. Generalized linear mixed effects models were used to examine 1) the role of the nose/throat microbiota on susceptibility to influenza virus and 2) changes in the nose/throat microbiota during influenza virus infection.
  • Data include variables used to run mixed effects models examining the association between the nose/throat microbiome and influenza virus infection. Certain individual participant data have been excluded due to identifiability concerns. Data also include the oligotype count table and taxonomic classifications.

  • Curation Notes: Readme updated Nov. 29, 2018 with context for oligotype and taxonomy files, and citation to associated article.
Contact information
Funding agency
  • National Institutes of Health (NIH)
Citations to related material
Resource type
Last modified
  • 04/22/2020
  • 10/02/2018
To Cite this Work:
Lee, K., Foxman, B., Gordon, A. (2018). Transmission of Oral microbiome and Sequencing - Influenza Susceptibility [Data set]. University of Michigan - Deep Blue.


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