Work Description

Title: Transmission of Oral microbiome and Sequencing - Influenza Susceptibility Open Access Deposited

Attribute Value
Methodology
  • Index cases of influenza were identified at a major healthcare facility in Managua, Nicaragua. Index cases and their family members were enrolled for follow up and with nose/throat samples collected at 2-3 day intervals for up to 13 days. Sociodemographic and household data were collected at enrollment. 16S rRNA sequencing (V4, Illumina MiSeq) was conducted on samples collected at enrollment and at the last day of follow up. Generalized linear mixed effects models were used to examine 1) the role of the nose/throat microbiota on susceptibility to influenza virus and 2) changes in the nose/throat microbiota during influenza virus infection.
Description
  • Data include variables used to run mixed effects models examining the association between the nose/throat microbiome and influenza virus infection. Certain individual participant data have been excluded due to identifiability concerns. Data also include the oligotype count table and taxonomic classifications.
Description
  • Curation Notes: Readme updated Nov. 29, 2018 with context for oligotype and taxonomy files, and citation to associated article.
Creator
Depositor
  • kyuhan@umich.edu
Contact information
Discipline
Funding agency
  • National Institutes of Health (NIH)
Other funding agency
  • National Institutes of Health (NIH)
Keyword
Date coverage
  • 2012-08-20 to 2014-11-17
Citations
  • Lee KH, Gordon A, Shedden K, Kuan G, Ng S, Balmaseda A, Foxman B. The respiratory microbiome and susceptibility to influenza virus infection. PloS One. 2019;14:e0207898. doi:10.1371/journal.pone.0207898
Resource type
Curation Notes for Users
  • Jan. 28, 2019: Changed Citation to related material from preprint (Lee KH, Gordon A, Shedden K, Kuan G, Ng S, Balmaseda A, Foxman B. The respiratory microbiome and susceptibility to influenza virus infection. bioRxiv. 2018; online preprint. https://doi.org/10.1101/372649) to published version.
Last modified
  • 01/29/2019
Language
DOI
  • doi:10.7302/Z2736P4B
CC License

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