Work Description

Title: Transmission of Oral microbiome and Sequencing - Influenza Susceptibility Open Access Deposited

http://creativecommons.org/publicdomain/zero/1.0/
Attribute Value
Methodology
  • Index cases of influenza were identified at a major healthcare facility in Managua, Nicaragua. Index cases and their family members were enrolled for follow up and with nose/throat samples collected at 2-3 day intervals for up to 13 days. Sociodemographic and household data were collected at enrollment. 16S rRNA sequencing (V4, Illumina MiSeq) was conducted on samples collected at enrollment and at the last day of follow up. Generalized linear mixed effects models were used to examine 1) the role of the nose/throat microbiota on susceptibility to influenza virus and 2) changes in the nose/throat microbiota during influenza virus infection.
Description
  • Data include variables used to run mixed effects models examining the association between the nose/throat microbiome and influenza virus infection. Certain individual participant data have been excluded due to identifiability concerns. Data also include the oligotype count table and taxonomic classifications.

  • Curation Notes: Readme updated Nov. 29, 2018 with context for oligotype and taxonomy files, and citation to associated article.
Creator
Depositor
  • kyuhan@umich.edu
Contact information
Discipline
Funding agency
  • National Institutes of Health (NIH)
Keyword
Date coverage
  • 2012-08-20 to 2014-11-17
Citations to related material
  • Lee KH, Gordon A, Shedden K, Kuan G, Ng S, Balmaseda A, Foxman B. The respiratory microbiome and susceptibility to influenza virus infection. PloS One. 2019;14:e0207898. doi:10.1371/journal.pone.0207898
Resource type
Last modified
  • 01/29/2019
Published
  • 10/02/2018
Language
DOI
License
To Cite this Work:
Lee, K., Foxman, B., Gordon, A. (2018). Transmission of Oral microbiome and Sequencing - Influenza Susceptibility [Data set]. University of Michigan - Deep Blue. https://doi.org/10.7302/Z2736P4B

Relationships

In Collection:

Files (Count: 4; Size: 956 KB)

Download All Files (To download individual files, select them in the “Files” panel above)

Best for data sets < 3 GB. Downloads all files plus metadata into a zip file.



Best for data sets > 3 GB. Globus is the platform Deep Blue Data uses to make large data sets available.   More about Globus