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Outcomes of regenerative treatment with rhPDGF‐BB and rhFGF‐2 for periodontal intra‐bony defects: a systematic review and meta‐analysis
dc.contributor.authorKhoshkam, Vahiden_US
dc.contributor.authorChan, Hsun‐liangen_US
dc.contributor.authorLin, Guo‐haoen_US
dc.contributor.authorMailoa, Jamesen_US
dc.contributor.authorGiannobile, William V.en_US
dc.contributor.authorWang, Hom‐layen_US
dc.contributor.authorOh, Tae‐juen_US
dc.date.accessioned2015-04-02T15:12:11Z
dc.date.available2016-05-10T20:26:28Zen
dc.date.issued2015-03en_US
dc.identifier.citationKhoshkam, Vahid; Chan, Hsun‐liang ; Lin, Guo‐hao ; Mailoa, James; Giannobile, William V.; Wang, Hom‐lay ; Oh, Tae‐ju (2015). "Outcomes of regenerative treatment with rhPDGFâ BB and rhFGFâ 2 for periodontal intraâ bony defects: a systematic review and metaâ analysis." Journal of Clinical Periodontology 42(3): 272-280.en_US
dc.identifier.issn0303-6979en_US
dc.identifier.issn1600-051Xen_US
dc.identifier.urihttps://hdl.handle.net/2027.42/110825
dc.description.abstractBackgroundThe aim was to evaluate the effects of recombinant human platelet‐derived growth factor‐BB (rhPDGF‐BB) and recombinant human fibroblast growth factor‐2 (rhFGF‐2) on treating periodontal intra‐bony defects, compared to the control (carrier alone).MethodsElectronic and hand searches were performed to identify eligible studies. The weighed mean differences of linear defect fill (LDF), probing depth (PD) reduction, clinical attachment level (CAL) gain and gingival recession (GR) were calculated using random effect meta‐analysis.ResultsThe searches yielded 1018 articles, of which seven studies were included. Only one included study was considered at low risk of bias. The outcomes that reached statistical significance in comparison to carriers alone included: LDF (0.95 mm, 95% CI: 0.62–1.28 mm or 20.17%, 95% CI: 11.81–28.54%) and CAL gain (0.34 mm, 95% CI: 0.03–0.65 mm) for PDGF, and LDF (21.22%, 95% CI: 5.82–36.61%) for FGF‐2.ConclusionsWithin the limits of this review, rhPDGF‐BB demonstrated significantly more LDF and CAL gain; rhFGF‐2 resulted in significantly higher percentage of LDF.en_US
dc.publisherWiley Periodicals, Inc.en_US
dc.subject.otheroral reconstruction and wound healingen_US
dc.subject.otherrepairen_US
dc.subject.otherbioengineeringen_US
dc.subject.otherregenerative medicineen_US
dc.subject.othertissue engineeringen_US
dc.titleOutcomes of regenerative treatment with rhPDGF‐BB and rhFGF‐2 for periodontal intra‐bony defects: a systematic review and meta‐analysisen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelDentistryen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/110825/1/jcpe12354.pdf
dc.identifier.doi10.1111/jcpe.12354en_US
dc.identifier.sourceJournal of Clinical Periodontologyen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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