Now showing items 31-40 of 44
TRH attenuates scopolamine-induced memory impairment in humans
(Springer-Verlag, 1990-03)
The brain tripeptide thyrotropin-releasing hormone (TRH) has been demonstrated to facilitate cholinergic neurotransmission. To test its interaction with the cholinergic system in humans, high-dose TRH (0.5 mg/kg) or placebo ...
Pharmacological profile of a potent, efficacious fentanyl derivative in rhesus monkeys
(Springer-Verlag, 1992-11)
The recent synthesis of fentanyl derivatives, some of which appear to have novel profiles of pharmacological effects, has provided compelling evidence that μ opioid efficacy might be altered systematically by modifications ...
Controlled dosing of nicotine via an I ntranasal N icotine A erosol D elivery D evice (INADD)
(Springer-Verlag, 1992-09)
The present report describes an I ntranasal N icotine A erosol D elivery D evice (INADD) employing an artist's airbrush as aerosolizer and precise, electromechanical control of spray duration. It was designed for the ...
Reinforcing and discriminative stimulus effects of the neuroactive steroids pregnanolone and Co 8-7071 in rhesus monkeys
(Springer-Verlag; Springer-Verlag Berlin Heidelberg, 1999-07)
Rationale and Objectives : The present study was designed to assess possible abuse-related effects of the endogenous neuroactive steroid pregnanolone (3α-hydroxy-5β-pregnan-20-one) and the orally bioavailable, water-soluble ...
Systemic effects of E-2078, a stabilized dynorphin A(1–8) analog, in rhesus monkeys
(Springer-Verlag; Springer-Verlag Berlin Heidelberg, 1999-04)
Rationale : E-2078 ([ N -methyl-Tyr 1 , N -methyl-Arg 7 , d -Leu 8 ] dynorphin A(1–8) ethylamide) is a dynorphin A(1–8) analog with a reduced tendency to be biotransformed, when compared to the unmodified opioid peptide. ...
Rebuttal of comments by Griffiths, Lader and Greenblatt to Review by Woods and Winger
(Springer-Verlag, 1995-03)
Naloxone blockade of amphetamine place preference conditioning
(Springer-Verlag, 1991-06)
Amphetamine and naloxone were examined in place conditioning, in order to study possible interactions between endogenous opioids and catecholamines in reinforcement. After initial preferences were determined, animals were ...
Effects of placebo (saline) injections on core temperature in the rat
(Elsevier, 1990)
1. Core temperature was telemetrically measured in 15 rats before (i.e., at baseline) and at 10-min intervals for 120 min following the injection of normal saline (1 ml/kg ip) or "no injection."2. The sample exhibited a ...
Sensitization to systemic amphetamine produces an enhanced locomotor response to a subsequent intra-accumbens amphetamine challenge in rats
(Springer-Verlag, 1991-05)
Repeated amphetamine (AMPH) administration into the nucleus accumbens does not enhance (sensitize) the locomotor activity produced by a subsequent systemic AMPH challenge. We report here, however, that pretreatment with ...
Time course of transient behavioral depression and persistent behavioral sensitization in relation to regional brain monoamine concentrations during amphetamine withdrawal in rats
(Springer-Verlag, 1991-04)
This experiment was designed to characterize the withdrawal syndrome produced by discontinuation of treatment with escalating, non-neurotoxic doses of d -amphetamine (AMPH). AMPH withdrawal was associated with both transient ...