Now showing items 461-466 of 466
The Role of PALS1 in Mammalian Epithelial Polarity.
(2007)
Polarity is an intrinsic feature of epithelial cells, and it is reflected by the differential distribution of proteins and lipids in the apical and basolateral surfaces. The apical and basolateral membranes are separated ...
Characterization of Amyloid-B Interactions at the Membrane Interface: Implications for Pathogenesis. Implications for Pathogenesis.
(2009)
The 40 and 42 residue amyloid-β (Aβ) peptides are major components of the proteinaceous plaques prevalent in the Alzheimer’s disease afflicted brain and have been shown to play an important role in instigating neuronal ...
Structures of Exocyst Subunit Exo70 from Yeast and Mouse.
(2007)
Exocytosis is a eukaryotic process in which vesicles deliver membrane and other cargoes to and across the plasma membrane. The exocyst is a tethering complex necessary for the polarization and fusion of exocytic vesicles ...
Enzyme Aging: Structural Insights from NTE and Patatin.
(2009)
Neuropathy target esterase (NTE) is an integral membrane protein whose covalent modification by organophosphorus compounds (OPs) results in a delayed axonopathy (called OP-induced delayed neuropathy (OPIDN)) whose mechanisms ...
Expanding the Set of Known Substrates of Nuclear RNase P.
(2007)
Ribonuclease P (RNase P) is an essential endonuclease found in all living organisms and is responsible for the removal of the 5’ leader sequence from precursor tRNAs (pre-tRNAs). In bacteria, RNase P is known to process ...
Roles of the Unfolded Protein Response in Cultured Cells and Transgenic Murine Models.
(2007)
When protein folding in the endoplasmic reticulum(ER) is disrupted by alterations in homeostasis in the ER lumen, eukaryotic cells activate a series of signal transduction cascades that are collectively termed the Unfolded ...