Now showing items 2101-2110 of 2128
Development of Nickel- and Palladium-Mediated Decarbonylative Coupling of Carboxylic Acid Derivatives: From Organometallic Reactivity to Catalysis
(2022)
Transition metal catalyzed cross coupling reactions are among the most widely used transformations in organic chemistry. While there has been tremendous work regarding aryl halide cross coupling, there has been growing ...
A Bidentate Ligand Featuring Ditopic Lewis Acids in the Second Sphere for Selective Substrate Capture and Activation
(Wiley Periodicals, Inc., 2023-03-20)
We present a ligand platform featuring appended ditopic Lewis acids to facilitate capture/activation of diatomic substrates. We show that incorporation of two 9-borabicyclo[3.3.1]nonane (9-BBN) units on a single carbon ...
Development of Group 10 Metal Catalyzed Decarbonylative Catalysis and Undergraduate Organic Chemistry 2 Lab Modules
(2022)
The development of novel methods to install fluoroalkyl groups into organic molecules is highly desirable due to the effects that fluorine atoms impart, such as metabolic stability and lipophilicity. Due to the commercial ...
Preparation and Functionalization of Mono- and Polyfluoroepoxides via Fluoroalkylation of Carbonyl Electrophiles
(Wiley, 2023-02-16)
We outline a new synthetic method to prepare mono- and polyfluoroepoxides from a diverse pool of electrophiles (ketones, acyl chlorides, esters) and fluoroalkyl anion equivalents. The initially formed α-fluoro alkoxides ...
Super-Strong Hydrogel Composites Reinforced with PBO Nanofibers for Cartilage Replacement
(Wiley Periodicals, Inc.Imperial College Press, 2023-02)
Cartilage replacement materials exhibiting a set of demanding properties such as high water content, high mechanical stiffness, low friction, and excellent biocompatibility are quite difficult to achieve. Here, ...
Molecular Rotational Correlation Times and Nanoviscosity Determined by 111mCd Perturbed Angular Correlation (PAC) of γ-rays Spectroscopy
(Wiley Periodicals, Inc.Springer, 2023-02-10)
The nanoviscosity experienced by molecules in solution may be determined through measurement of the molecular rotational correlation time, τc, for example, by fluorescence and NMR spectroscopy. With this work, we apply PAC ...
Biocatalytic P450 Oxidative Phenolic Coupling Reactions for Biaryl-bond Formation
(2022)
Atropisomers, derived from the Greek word “atropos,” meaning “without turn”, are chiral molecules that possess a bond that is sterically hindered, impeding free rotation around that bond. This structural feature impacts ...
Sum Frequency Generation and Molecular Dynamics Studies of Biomolecular Orientation at Model Interfaces.
(2011)
Interfaces are ubiquitous in biology, yet few techniques can provide a direct, specific, and in situ means to study the structure of interfacial biomolecules. Recent advances in vibrational spectroscopic techniques are ...
YfeX – A New Platform for Carbene Transferase Development with High Intrinsic Reactivity
(SpringerWiley Periodicals, Inc., 2022-11-21)
Carbene transfer biocatalysis has evolved from basic science to an area with vast potential for the development of new industrial processes. In this study, we show that YfeX, naturally a peroxidase, has great potential for ...
Reply to Correspondence on “Synergy and Antagonism between Allosteric and Active-Site Inhibitors of Abl Tyrosine Kinase”
(Wiley Periodicals, Inc., 2022-11-14)
Manley and co-workers provide data demonstrating that, at super-pharmacological concentrations (300 μM), a ternary complex between Abl, asciminib, and ATP-competitive inhibitors is possible. The work in our manuscript ...