Now showing items 9781-9790 of 9801
"Nanotheranostics" for Tumor Imaging and Targeted Drug Delivery.
(2011)
The magnetic resonance imaging (MRI) technique is a promising tool that improves cancer detection, facilitates diagnosis and monitors therapeutic effects. Superparamagnetic iron oxide nanoparticles (SPIOs) have emerged as ...
Metals, Noise, Diet, and Hearing Loss.
(2011)
Hearing loss is one of the most common chronic health disabilities experienced by older adults, and the prevalence of hearing loss tends to increase dramatically with advancing age. Therefore, identification of modifiable ...
Some Novel Spatial Stochastic Models for Functional Neuroimaging Analysis.
(2011)
In this dissertation, we develop some new spatial point process models and discuss their applications to the analysis of functional neuroimaging data. In the first project, we propose a Bayesian spatial hierarchical model ...
The Landscape of C. elegans 3'UTRs.
(2011)
The 3’ untranslated regions (3’UTRs) of mRNAs have recently been shown to play major roles in gene regulation by interaction with small (21-26nt length) RNAs, such as microRNAs and small interfering RNAs (siRNAs). Recent ...
Role of Persistent Pathogens, Total Pathogen Burden and Inflammation in Determining Risk for All-Cause and Cardiovascular Disease-related Mortality in the United States.
(2011)
Although life expectancy has steadily increased in the United States (U.S.), socioeconomic disparities in risk for mortality persist, indicating the need to identify novel risk factors linking socioeconomic position (SEP) ...
Allosteric Regulation of Gs on Agonist, Antagonist and Inverse Agonish Binding to the
(2011)
G protein-coupled receptors are seven transmembrane domain proteins that regulate a diverse array of cellular functions primarily through G protein-mediated signaling. GPCR function can be regulated by different ligands ...
Mechanisms of Bacillus anthracis spore cortex degradation.
(2011)
Bacillus anthracis exists in two morphologically distinct states, the spore and the vegetative cell. The deadly animal and human disease anthrax results from B. anthracis spores entering a suitable host and transitioning ...
LINE-1 Retrotransposition in Human Genomic Variation.
(2012)
Long interspersed element-1 (LINE-1 or L1) is a ubiquitous mobile element in mammalian genomes. There are ~500,000 copies of L1 throughout the human genome, comprising ~17% of our DNA. Interestingly, though the majority ...
Alternative Androgen Metabolism in Resistance to Aromatase Inhibitors.
(2011)
The treatment of estrogen-receptor positive breast cancer is based on endocrine therapy, with aromatase inhibitors (AIs) serving as the current front-line therapy in post-menopausal women. Despite prolonging disease-free ...
Diabetes Health and Disability Pathways: Racial/Ethnic, Socioeconomic, and Gender Disparities.
(2010)
This dissertation examines how race/ethnicity, socioeconomic status, and gender relate to longitudinal health outcomes among older adults with type 2 diabetes. Further, this dissertation analyzes the extent to which certain ...